Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation
A total of 182 young adult male Wistar rats were bilaterally implanted with cannulae into the CA1 region of the dorsal hippocampus and into the amygdaloid nucleus, the entorhinal cortex, and the posterior parietal cortex. After recovery, the animals were trained in a step-down inhibitory avoidance t...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
1997-02-01
|
| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000200012 |
| _version_ | 1819150380439699456 |
|---|---|
| author | M.S. Zanatta J.H. Quillfeldt E. Schaeffer P.K. Schmitz J. Quevedo J.H. Medina I. Izquierdo |
| author_facet | M.S. Zanatta J.H. Quillfeldt E. Schaeffer P.K. Schmitz J. Quevedo J.H. Medina I. Izquierdo |
| author_sort | M.S. Zanatta |
| collection | DOAJ |
| description | A total of 182 young adult male Wistar rats were bilaterally implanted with cannulae into the CA1 region of the dorsal hippocampus and into the amygdaloid nucleus, the entorhinal cortex, and the posterior parietal cortex. After recovery, the animals were trained in a step-down inhibitory avoidance task. At various times after training (0, 30, 60 or 90 min) the animals received a 0.5-µl microinfusion of vehicle (saline) or 0.5 µg of muscimol dissolved in the vehicle. A retention test was carried out 24 h after training. Retention test performance was hindered by muscimol administered into both the hippocampus and amygdala at 0 but not at 30 min posttraining. The drug was amnestic when given into the entorhinal cortex 30, 60 or 90 min after training, or into the parietal cortex 60 or 90 min after training, but not before. These findings suggest a sequential entry operation, during the posttraining period, of the hippocampus and amygdala, the entorhinal cortex, and the posterior parietal cortex in memory processing |
| first_indexed | 2024-12-22T14:16:35Z |
| format | Article |
| id | doaj.art-cb90ad6af57c4f988e4ccb4fe49a711a |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-22T14:16:35Z |
| publishDate | 1997-02-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-cb90ad6af57c4f988e4ccb4fe49a711a2022-12-21T18:23:06ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X1997-02-0130223510.1590/S0100-879X1997000200012Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidationM.S. ZanattaJ.H. QuillfeldtE. SchaefferP.K. SchmitzJ. QuevedoJ.H. MedinaI. IzquierdoA total of 182 young adult male Wistar rats were bilaterally implanted with cannulae into the CA1 region of the dorsal hippocampus and into the amygdaloid nucleus, the entorhinal cortex, and the posterior parietal cortex. After recovery, the animals were trained in a step-down inhibitory avoidance task. At various times after training (0, 30, 60 or 90 min) the animals received a 0.5-µl microinfusion of vehicle (saline) or 0.5 µg of muscimol dissolved in the vehicle. A retention test was carried out 24 h after training. Retention test performance was hindered by muscimol administered into both the hippocampus and amygdala at 0 but not at 30 min posttraining. The drug was amnestic when given into the entorhinal cortex 30, 60 or 90 min after training, or into the parietal cortex 60 or 90 min after training, but not before. These findings suggest a sequential entry operation, during the posttraining period, of the hippocampus and amygdala, the entorhinal cortex, and the posterior parietal cortex in memory processinghttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000200012Memory consolidationHippocampus and amygdalaEntorhinal cortexParietal cortex |
| spellingShingle | M.S. Zanatta J.H. Quillfeldt E. Schaeffer P.K. Schmitz J. Quevedo J.H. Medina I. Izquierdo Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation Brazilian Journal of Medical and Biological Research Memory consolidation Hippocampus and amygdala Entorhinal cortex Parietal cortex |
| title | Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation |
| title_full | Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation |
| title_fullStr | Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation |
| title_full_unstemmed | Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation |
| title_short | Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation |
| title_sort | involvement of the hippocampus amygdala entorhinal cortex and posterior parietal cortex in memory consolidation |
| topic | Memory consolidation Hippocampus and amygdala Entorhinal cortex Parietal cortex |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000200012 |
| work_keys_str_mv | AT mszanatta involvementofthehippocampusamygdalaentorhinalcortexandposteriorparietalcortexinmemoryconsolidation AT jhquillfeldt involvementofthehippocampusamygdalaentorhinalcortexandposteriorparietalcortexinmemoryconsolidation AT eschaeffer involvementofthehippocampusamygdalaentorhinalcortexandposteriorparietalcortexinmemoryconsolidation AT pkschmitz involvementofthehippocampusamygdalaentorhinalcortexandposteriorparietalcortexinmemoryconsolidation AT jquevedo involvementofthehippocampusamygdalaentorhinalcortexandposteriorparietalcortexinmemoryconsolidation AT jhmedina involvementofthehippocampusamygdalaentorhinalcortexandposteriorparietalcortexinmemoryconsolidation AT iizquierdo involvementofthehippocampusamygdalaentorhinalcortexandposteriorparietalcortexinmemoryconsolidation |