Initial disease severity and quality of care of emergency department sepsis patients who are older or younger than 70 years of age.
Due to atypical symptom presentation older patients are more prone to delayed sepsis recognition. We investigated whether initial disease severity before emergency department (ED) treatment (including treatable acute organ dysfunction), quality of ED sepsis care and the impact on mortality was diffe...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5612649?pdf=render |
| _version_ | 1819023642464354304 |
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| author | Mats Warmerdam Frank Stolwijk Anjelica Boogert Meera Sharma Lisa Tetteroo Jacinta Lucke Simon Mooijaart Annemieke Ansems Laura Esteve Cuevas Douwe Rijpsma Bas de Groot |
| author_facet | Mats Warmerdam Frank Stolwijk Anjelica Boogert Meera Sharma Lisa Tetteroo Jacinta Lucke Simon Mooijaart Annemieke Ansems Laura Esteve Cuevas Douwe Rijpsma Bas de Groot |
| author_sort | Mats Warmerdam |
| collection | DOAJ |
| description | Due to atypical symptom presentation older patients are more prone to delayed sepsis recognition. We investigated whether initial disease severity before emergency department (ED) treatment (including treatable acute organ dysfunction), quality of ED sepsis care and the impact on mortality was different between patients older and younger than 70 years. If differences exist, improvements are needed for ED management of older patients at risk for sepsis.In this observational multicenter study, ED patients who were hospitalized with a suspected infection were stratified by age <70 and ≥70 years. The presence of treatable and potentially reversible acute organ dysfunction was measured by the RO components of the Predisposition, Infection, Response and Organ dysfunction (PIRO) score, reflecting acute sepsis-related organ dysfunction developed before ED presentation. Quality of care, as assessed by the full compliance with nine quality performance measures and the standardized mortality ratio (SMR: observed/expected in-hospital mortality), was compared between older and younger patients.The RO-components of the PIRO score were 8 (interquartile range; 4-9) in the 833 older patients, twice as high as the 4 (2-8; P<0.001) in the 1537 younger patients. However, full compliance with all nine quality performance measures was achieved in 34.2 (31.0-37.4)% of the older patients, not higher than the 33.0 (30.7-35.4)% in younger patients (P = 0.640). In-hospital mortality was 9.2% (95%-CI, 7.3-11.2) in patients ≥70, twice as high as the 4.6% (3.6-5.6) in patients <70 years, resulting in an SMR (in study period) of ~0.7 in both groups (P>0.05).Older sepsis patients are sicker at ED presentation but are not treated more expediently or reliably despite their extra acuity The presence of twice as much treatable acute organ dysfunction before ED treatment suggests that acute organ dysfunction is recognized relatively late by general practitioners or patients in the out of hospital setting. |
| first_indexed | 2024-12-21T04:42:08Z |
| format | Article |
| id | doaj.art-cb90bf8eb5a34646a7cba5e727872d96 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T04:42:08Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cb90bf8eb5a34646a7cba5e727872d962022-12-21T19:15:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01129e018521410.1371/journal.pone.0185214Initial disease severity and quality of care of emergency department sepsis patients who are older or younger than 70 years of age.Mats WarmerdamFrank StolwijkAnjelica BoogertMeera SharmaLisa TetterooJacinta LuckeSimon MooijaartAnnemieke AnsemsLaura Esteve CuevasDouwe RijpsmaBas de GrootDue to atypical symptom presentation older patients are more prone to delayed sepsis recognition. We investigated whether initial disease severity before emergency department (ED) treatment (including treatable acute organ dysfunction), quality of ED sepsis care and the impact on mortality was different between patients older and younger than 70 years. If differences exist, improvements are needed for ED management of older patients at risk for sepsis.In this observational multicenter study, ED patients who were hospitalized with a suspected infection were stratified by age <70 and ≥70 years. The presence of treatable and potentially reversible acute organ dysfunction was measured by the RO components of the Predisposition, Infection, Response and Organ dysfunction (PIRO) score, reflecting acute sepsis-related organ dysfunction developed before ED presentation. Quality of care, as assessed by the full compliance with nine quality performance measures and the standardized mortality ratio (SMR: observed/expected in-hospital mortality), was compared between older and younger patients.The RO-components of the PIRO score were 8 (interquartile range; 4-9) in the 833 older patients, twice as high as the 4 (2-8; P<0.001) in the 1537 younger patients. However, full compliance with all nine quality performance measures was achieved in 34.2 (31.0-37.4)% of the older patients, not higher than the 33.0 (30.7-35.4)% in younger patients (P = 0.640). In-hospital mortality was 9.2% (95%-CI, 7.3-11.2) in patients ≥70, twice as high as the 4.6% (3.6-5.6) in patients <70 years, resulting in an SMR (in study period) of ~0.7 in both groups (P>0.05).Older sepsis patients are sicker at ED presentation but are not treated more expediently or reliably despite their extra acuity The presence of twice as much treatable acute organ dysfunction before ED treatment suggests that acute organ dysfunction is recognized relatively late by general practitioners or patients in the out of hospital setting.http://europepmc.org/articles/PMC5612649?pdf=render |
| spellingShingle | Mats Warmerdam Frank Stolwijk Anjelica Boogert Meera Sharma Lisa Tetteroo Jacinta Lucke Simon Mooijaart Annemieke Ansems Laura Esteve Cuevas Douwe Rijpsma Bas de Groot Initial disease severity and quality of care of emergency department sepsis patients who are older or younger than 70 years of age. PLoS ONE |
| title | Initial disease severity and quality of care of emergency department sepsis patients who are older or younger than 70 years of age. |
| title_full | Initial disease severity and quality of care of emergency department sepsis patients who are older or younger than 70 years of age. |
| title_fullStr | Initial disease severity and quality of care of emergency department sepsis patients who are older or younger than 70 years of age. |
| title_full_unstemmed | Initial disease severity and quality of care of emergency department sepsis patients who are older or younger than 70 years of age. |
| title_short | Initial disease severity and quality of care of emergency department sepsis patients who are older or younger than 70 years of age. |
| title_sort | initial disease severity and quality of care of emergency department sepsis patients who are older or younger than 70 years of age |
| url | http://europepmc.org/articles/PMC5612649?pdf=render |
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