MicroRNAs as efficient biomarkers in high-grade gliomas
High-grade gliomas are the most aggressive and devastating brain neoplasms. Therefore much effort is put on understanding their background as well as development of new effective diagnostic and therapeutic methods. However, until now the genetic only approach has not provided a satisfactory answer....
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2016-12-01
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| Series: | Folia Neuropathologica |
| Subjects: | |
| Online Access: | https://www.termedia.pl/MicroRNAs-as-efficient-biomarkers-in-high-grade-gliomas,20,28975,1,1.html |
| _version_ | 1819147236285612032 |
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| author | Anna-Maria Barciszewska |
| author_facet | Anna-Maria Barciszewska |
| author_sort | Anna-Maria Barciszewska |
| collection | DOAJ |
| description | High-grade gliomas are the most aggressive and devastating brain neoplasms. Therefore much effort is put on understanding their background as well as development of new effective diagnostic and therapeutic methods. However, until now the genetic only approach has not provided a satisfactory answer. Recently, it has been shown that the epigenetic issue is important for high-grade gliomas’ development and progression. Out of many epigenetic mechanisms, as DNA methylation, histone methylation and acetylation, especially microRNAs showed to be deeply involved in the carcinogenesis process.
MicroRNAs are short non-coding RNAs. They are new candidates for human disease biomarkers due to their simple identification. MicroRNAs are stable in tissue and body fluids, what makes them very prospective non-invasive, blood-based biomarkers. There is a lot of data showing that various profiles of serum microRNAs are linked to numerous neoplastic processes, indicating that microRNAs can be really a new class of biomarkers for human diseases. |
| first_indexed | 2024-12-22T13:26:36Z |
| format | Article |
| id | doaj.art-cb91e46f2f794d4f924dcb6408ed9d11 |
| institution | Directory Open Access Journal |
| issn | 1641-4640 1509-572X |
| language | English |
| last_indexed | 2024-12-22T13:26:36Z |
| publishDate | 2016-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Folia Neuropathologica |
| spelling | doaj.art-cb91e46f2f794d4f924dcb6408ed9d112022-12-21T18:24:18ZengTermedia Publishing HouseFolia Neuropathologica1641-46401509-572X2016-12-0154436937410.5114/fn.2016.6481228975MicroRNAs as efficient biomarkers in high-grade gliomasAnna-Maria BarciszewskaHigh-grade gliomas are the most aggressive and devastating brain neoplasms. Therefore much effort is put on understanding their background as well as development of new effective diagnostic and therapeutic methods. However, until now the genetic only approach has not provided a satisfactory answer. Recently, it has been shown that the epigenetic issue is important for high-grade gliomas’ development and progression. Out of many epigenetic mechanisms, as DNA methylation, histone methylation and acetylation, especially microRNAs showed to be deeply involved in the carcinogenesis process. MicroRNAs are short non-coding RNAs. They are new candidates for human disease biomarkers due to their simple identification. MicroRNAs are stable in tissue and body fluids, what makes them very prospective non-invasive, blood-based biomarkers. There is a lot of data showing that various profiles of serum microRNAs are linked to numerous neoplastic processes, indicating that microRNAs can be really a new class of biomarkers for human diseases.https://www.termedia.pl/MicroRNAs-as-efficient-biomarkers-in-high-grade-gliomas,20,28975,1,1.htmlmicroRNA miRNA miR biomarker high-grade glioma HGG glioblastoma GBM |
| spellingShingle | Anna-Maria Barciszewska MicroRNAs as efficient biomarkers in high-grade gliomas Folia Neuropathologica microRNA miRNA miR biomarker high-grade glioma HGG glioblastoma GBM |
| title | MicroRNAs as efficient biomarkers in high-grade gliomas |
| title_full | MicroRNAs as efficient biomarkers in high-grade gliomas |
| title_fullStr | MicroRNAs as efficient biomarkers in high-grade gliomas |
| title_full_unstemmed | MicroRNAs as efficient biomarkers in high-grade gliomas |
| title_short | MicroRNAs as efficient biomarkers in high-grade gliomas |
| title_sort | micrornas as efficient biomarkers in high grade gliomas |
| topic | microRNA miRNA miR biomarker high-grade glioma HGG glioblastoma GBM |
| url | https://www.termedia.pl/MicroRNAs-as-efficient-biomarkers-in-high-grade-gliomas,20,28975,1,1.html |
| work_keys_str_mv | AT annamariabarciszewska micrornasasefficientbiomarkersinhighgradegliomas |