Escitalopram enhances synchrony of brain responses during emotional narratives in patients with major depressive disorder
One-week treatment with escitalopram decreases amygdala responses to fearful facial expressions in depressed patients, but it remains unknown whether it also modulates processing of complex and freely processed emotional stimuli resembling daily life emotional situations. Inter-subject correlation (...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921003876 |
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| author | Emma Komulainen Enrico Glerean Roope Heikkilä Lauri Nummenmaa Tuukka T. Raij Erkki Isometsä Jesper Ekelund |
| author_facet | Emma Komulainen Enrico Glerean Roope Heikkilä Lauri Nummenmaa Tuukka T. Raij Erkki Isometsä Jesper Ekelund |
| author_sort | Emma Komulainen |
| collection | DOAJ |
| description | One-week treatment with escitalopram decreases amygdala responses to fearful facial expressions in depressed patients, but it remains unknown whether it also modulates processing of complex and freely processed emotional stimuli resembling daily life emotional situations. Inter-subject correlation (ISC) offers a means to track brain activity during complex, dynamic stimuli in a model-free manner.Twenty-nine treatment-seeking patients with major depressive disorder were randomized in a double-blind study design to receive either escitalopram or placebo for one week, after which functional magnetic resonance imaging (fMRI) was performed. During fMRI the participants listened to spoken emotional narratives. Level of ISC between the escitalopram and the placebo group was compared across all the narratives and separately for the episodes with positive and negative valence.Across all the narratives, the escitalopram group had higher ISC in the default mode network of the brain as well as in the fronto-temporal narrative processing regions, whereas lower ISC was seen in the middle temporal cortex, hippocampus and occipital cortex. Escitalopram increased ISC during positive parts of the narratives in the precuneus, medial prefrontal cortex, anterior cingulate and fronto-insular cortex, whereas there was no significant synchronization in brain responses to positive vs negative events in the placebo group. Increased ISC may imply improved emotional synchronization with others, particularly during observation of positive events. Further studies are needed to test whether this contributes to the later therapeutic effect of escitalopram. |
| first_indexed | 2024-12-17T03:05:17Z |
| format | Article |
| id | doaj.art-cb92e70a2a144cd588023d1bc1069cd5 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-17T03:05:17Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-cb92e70a2a144cd588023d1bc1069cd52022-12-21T22:05:58ZengElsevierNeuroImage1095-95722021-08-01237118110Escitalopram enhances synchrony of brain responses during emotional narratives in patients with major depressive disorderEmma Komulainen0Enrico Glerean1Roope Heikkilä2Lauri Nummenmaa3Tuukka T. Raij4Erkki Isometsä5Jesper Ekelund6University of Helsinki and Helsinki University Hospital, Psychiatry, Helsinki, Finland; Corresponding author.Aalto University, School of Science, Department of Neuroscience and Biomedical Engineering, Espoo, Finland; International Laboratory of Social Neurobiology, Institute of Cognitive Neuroscience, National Research University Higher School of Economics, Moscow, RussiaUniversity of Helsinki and Helsinki University Hospital, Psychiatry, Helsinki, FinlandTurku PET Centre and Department of Psychology, University of Turku, FinlandUniversity of Helsinki and Helsinki University Hospital, Psychiatry, Helsinki, Finland; Aalto University, School of Science, Department of Neuroscience and Biomedical Engineering, Espoo, Finland; Aalto NeuroImaging, Aalto University, Espoo, FinlandUniversity of Helsinki and Helsinki University Hospital, Psychiatry, Helsinki, FinlandUniversity of Helsinki and Helsinki University Hospital, Psychiatry, Helsinki, FinlandOne-week treatment with escitalopram decreases amygdala responses to fearful facial expressions in depressed patients, but it remains unknown whether it also modulates processing of complex and freely processed emotional stimuli resembling daily life emotional situations. Inter-subject correlation (ISC) offers a means to track brain activity during complex, dynamic stimuli in a model-free manner.Twenty-nine treatment-seeking patients with major depressive disorder were randomized in a double-blind study design to receive either escitalopram or placebo for one week, after which functional magnetic resonance imaging (fMRI) was performed. During fMRI the participants listened to spoken emotional narratives. Level of ISC between the escitalopram and the placebo group was compared across all the narratives and separately for the episodes with positive and negative valence.Across all the narratives, the escitalopram group had higher ISC in the default mode network of the brain as well as in the fronto-temporal narrative processing regions, whereas lower ISC was seen in the middle temporal cortex, hippocampus and occipital cortex. Escitalopram increased ISC during positive parts of the narratives in the precuneus, medial prefrontal cortex, anterior cingulate and fronto-insular cortex, whereas there was no significant synchronization in brain responses to positive vs negative events in the placebo group. Increased ISC may imply improved emotional synchronization with others, particularly during observation of positive events. Further studies are needed to test whether this contributes to the later therapeutic effect of escitalopram.http://www.sciencedirect.com/science/article/pii/S1053811921003876Major depressive disorderfMRIEmotionEscitalopramInter-subject correlation |
| spellingShingle | Emma Komulainen Enrico Glerean Roope Heikkilä Lauri Nummenmaa Tuukka T. Raij Erkki Isometsä Jesper Ekelund Escitalopram enhances synchrony of brain responses during emotional narratives in patients with major depressive disorder NeuroImage Major depressive disorder fMRI Emotion Escitalopram Inter-subject correlation |
| title | Escitalopram enhances synchrony of brain responses during emotional narratives in patients with major depressive disorder |
| title_full | Escitalopram enhances synchrony of brain responses during emotional narratives in patients with major depressive disorder |
| title_fullStr | Escitalopram enhances synchrony of brain responses during emotional narratives in patients with major depressive disorder |
| title_full_unstemmed | Escitalopram enhances synchrony of brain responses during emotional narratives in patients with major depressive disorder |
| title_short | Escitalopram enhances synchrony of brain responses during emotional narratives in patients with major depressive disorder |
| title_sort | escitalopram enhances synchrony of brain responses during emotional narratives in patients with major depressive disorder |
| topic | Major depressive disorder fMRI Emotion Escitalopram Inter-subject correlation |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921003876 |
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