Environmental epigenetics in zebrafish
Abstract It is widely accepted that the epigenome can act as the link between environmental cues, both external and internal, to the organism and phenotype by converting the environmental stimuli to phenotypic responses through changes in gene transcription outcomes. Environmental stress endured by...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2017-10-01
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| Series: | Epigenetics & Chromatin |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13072-017-0154-0 |
| _version_ | 1818389324232654848 |
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| author | Vincenzo Cavalieri Giovanni Spinelli |
| author_facet | Vincenzo Cavalieri Giovanni Spinelli |
| author_sort | Vincenzo Cavalieri |
| collection | DOAJ |
| description | Abstract It is widely accepted that the epigenome can act as the link between environmental cues, both external and internal, to the organism and phenotype by converting the environmental stimuli to phenotypic responses through changes in gene transcription outcomes. Environmental stress endured by individual organisms can also enforce epigenetic variations in offspring that had never experienced it directly, which is termed transgenerational inheritance. To date, research in the environmental epigenetics discipline has used a wide range of both model and non-model organisms to elucidate the various epigenetic mechanisms underlying the adaptive response to environmental stimuli. In this review, we discuss the advantages of the zebrafish model for studying how environmental toxicant exposures affect the regulation of epigenetic processes, especially DNA methylation, which is the best-studied epigenetic mechanism. We include several very recent studies describing the state-of-the-art knowledge on this topic in zebrafish, together with key concepts in the function of DNA methylation during vertebrate embryogenesis. |
| first_indexed | 2024-12-14T04:39:55Z |
| format | Article |
| id | doaj.art-cb9359f08b0247f8bdd82a26eaedeefe |
| institution | Directory Open Access Journal |
| issn | 1756-8935 |
| language | English |
| last_indexed | 2024-12-14T04:39:55Z |
| publishDate | 2017-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Epigenetics & Chromatin |
| spelling | doaj.art-cb9359f08b0247f8bdd82a26eaedeefe2022-12-21T23:16:50ZengBMCEpigenetics & Chromatin1756-89352017-10-0110111110.1186/s13072-017-0154-0Environmental epigenetics in zebrafishVincenzo Cavalieri0Giovanni Spinelli1Laboratory of Molecular Biology and Functional Genomics, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of PalermoLaboratory of Molecular Biology and Functional Genomics, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of PalermoAbstract It is widely accepted that the epigenome can act as the link between environmental cues, both external and internal, to the organism and phenotype by converting the environmental stimuli to phenotypic responses through changes in gene transcription outcomes. Environmental stress endured by individual organisms can also enforce epigenetic variations in offspring that had never experienced it directly, which is termed transgenerational inheritance. To date, research in the environmental epigenetics discipline has used a wide range of both model and non-model organisms to elucidate the various epigenetic mechanisms underlying the adaptive response to environmental stimuli. In this review, we discuss the advantages of the zebrafish model for studying how environmental toxicant exposures affect the regulation of epigenetic processes, especially DNA methylation, which is the best-studied epigenetic mechanism. We include several very recent studies describing the state-of-the-art knowledge on this topic in zebrafish, together with key concepts in the function of DNA methylation during vertebrate embryogenesis.http://link.springer.com/article/10.1186/s13072-017-0154-0Environmental epigeneticsZebrafishDNA methylationMethylomeHistone modificationsEmbryogenesis |
| spellingShingle | Vincenzo Cavalieri Giovanni Spinelli Environmental epigenetics in zebrafish Epigenetics & Chromatin Environmental epigenetics Zebrafish DNA methylation Methylome Histone modifications Embryogenesis |
| title | Environmental epigenetics in zebrafish |
| title_full | Environmental epigenetics in zebrafish |
| title_fullStr | Environmental epigenetics in zebrafish |
| title_full_unstemmed | Environmental epigenetics in zebrafish |
| title_short | Environmental epigenetics in zebrafish |
| title_sort | environmental epigenetics in zebrafish |
| topic | Environmental epigenetics Zebrafish DNA methylation Methylome Histone modifications Embryogenesis |
| url | http://link.springer.com/article/10.1186/s13072-017-0154-0 |
| work_keys_str_mv | AT vincenzocavalieri environmentalepigeneticsinzebrafish AT giovannispinelli environmentalepigeneticsinzebrafish |