Pathogenesis of Trousseau’s syndrome
After the first observations A. Trousseau in 1865, it is exist a host of studies on the relationship between the pathogenesis of cancer and thrombosis. There is now no doubt that the cancer patients occur much more frequently thromboembolism, and migratory venous thrombosis is a manifestation of par...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2016-06-01
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| Series: | Акушерство, гинекология и репродукция |
| Subjects: | |
| Online Access: | https://www.gynecology.su/jour/article/view/162 |
| _version_ | 1797884151761731584 |
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| author | A. V. Vorobev A. M. Chabrov A. A. MD, Ph.D., head of gynecological department S. V. Bulgakova A. D. Makatsariya |
| author_facet | A. V. Vorobev A. M. Chabrov A. A. MD, Ph.D., head of gynecological department S. V. Bulgakova A. D. Makatsariya |
| author_sort | A. V. Vorobev |
| collection | DOAJ |
| description | After the first observations A. Trousseau in 1865, it is exist a host of studies on the relationship between the pathogenesis of cancer and thrombosis. There is now no doubt that the cancer patients occur much more frequently thromboembolism, and migratory venous thrombosis is a manifestation of paraneoplastic syndrome in cancer patients. In general, any manifestation of thrombohemorrhagic complications in cancer patients called Trousseau’s syndrome. While thrombotic complications such as venous thromboembolism are most frequent in cancer patients, may also experience severe bleeding symptoms due to systemic coagulopathies, including disseminated intravascular coagulation, haemolytic thrombotic microangiopathy, and hyperfibrinolysis. The basis of the pathophysiology of Trousseau’s syndrome, except the classic triad of Virchow, is overproduction of tissue factor, the main initiator of extrinsic coagulation pathway. Thus a significant release of microparticles from tumor cells bearing tissue factor is critical not only for the formation of a blood clot, but the growth and progression of tumors. Tumor cells activate the coagulation cascade or fibrinolysis system, providing conditions for its further spread, stimulation of angiogenesis, increased vascular permeability, which in turn promotes metastasis |
| first_indexed | 2024-04-10T04:03:05Z |
| format | Article |
| id | doaj.art-cb943961591d418c9e9a19731165768a |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2024-04-10T04:03:05Z |
| publishDate | 2016-06-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-cb943961591d418c9e9a19731165768a2023-03-13T07:09:47ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942016-06-01929910910.17749/2070-4968.2015.9.2.099-109160Pathogenesis of Trousseau’s syndromeA. V. Vorobev0A. M. Chabrov1A. A. MD, Ph.D., head of gynecological department2S. V. Bulgakova3A. D. Makatsariya4First Moscow State Medical Sechenov University of the Ministry of Health Russian FederationFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationFirst Moscow State Medical Sechenov University of the Ministry of Health Russian FederationAfter the first observations A. Trousseau in 1865, it is exist a host of studies on the relationship between the pathogenesis of cancer and thrombosis. There is now no doubt that the cancer patients occur much more frequently thromboembolism, and migratory venous thrombosis is a manifestation of paraneoplastic syndrome in cancer patients. In general, any manifestation of thrombohemorrhagic complications in cancer patients called Trousseau’s syndrome. While thrombotic complications such as venous thromboembolism are most frequent in cancer patients, may also experience severe bleeding symptoms due to systemic coagulopathies, including disseminated intravascular coagulation, haemolytic thrombotic microangiopathy, and hyperfibrinolysis. The basis of the pathophysiology of Trousseau’s syndrome, except the classic triad of Virchow, is overproduction of tissue factor, the main initiator of extrinsic coagulation pathway. Thus a significant release of microparticles from tumor cells bearing tissue factor is critical not only for the formation of a blood clot, but the growth and progression of tumors. Tumor cells activate the coagulation cascade or fibrinolysis system, providing conditions for its further spread, stimulation of angiogenesis, increased vascular permeability, which in turn promotes metastasishttps://www.gynecology.su/jour/article/view/162trousseau’s syndromemalignanciesthrombotic complicationshemostasis systemmetastasis of tumor tissuedicthrombophiliapathogenesis of thrombotic complicationscancer patientsprevention of thrombosishemostasis disorders |
| spellingShingle | A. V. Vorobev A. M. Chabrov A. A. MD, Ph.D., head of gynecological department S. V. Bulgakova A. D. Makatsariya Pathogenesis of Trousseau’s syndrome Акушерство, гинекология и репродукция trousseau’s syndrome malignancies thrombotic complications hemostasis system metastasis of tumor tissue dic thrombophilia pathogenesis of thrombotic complications cancer patients prevention of thrombosis hemostasis disorders |
| title | Pathogenesis of Trousseau’s syndrome |
| title_full | Pathogenesis of Trousseau’s syndrome |
| title_fullStr | Pathogenesis of Trousseau’s syndrome |
| title_full_unstemmed | Pathogenesis of Trousseau’s syndrome |
| title_short | Pathogenesis of Trousseau’s syndrome |
| title_sort | pathogenesis of trousseau s syndrome |
| topic | trousseau’s syndrome malignancies thrombotic complications hemostasis system metastasis of tumor tissue dic thrombophilia pathogenesis of thrombotic complications cancer patients prevention of thrombosis hemostasis disorders |
| url | https://www.gynecology.su/jour/article/view/162 |
| work_keys_str_mv | AT avvorobev pathogenesisoftrousseaussyndrome AT amchabrov pathogenesisoftrousseaussyndrome AT aamdphdheadofgynecologicaldepartment pathogenesisoftrousseaussyndrome AT svbulgakova pathogenesisoftrousseaussyndrome AT admakatsariya pathogenesisoftrousseaussyndrome |