Preparation, characterization and in vivo pharmacokinetic study of ginsenoside Rb1-PLGA nanoparticles

Preparation, characterization and in vivo pharmacokinetic study of ginsenoside Rb1-PLGA nanoparticles

Abstract This study aimed to construct a Ginsenoside Rb1-PLGA nano drug delivery system, optimize its preparation process, characterize and evaluate the resulting Ginsenoside Rb1-PLGA Nanoparticles (GRb1@PLGA@NPs). GRb1@PLGA@NPs were prepared using the emulsion solvent evaporation method. The optima...

Full description

Bibliographic Details
Main Authors:	Lixin Du, Huiling Lu, Yifei Xiao, Zhihua Guo, Ya Li
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-10-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-023-45858-x

Similar Items

Therapeutic Potential of Ginsenoside Rb1-PLGA Nanoparticles for Heart Failure Treatment via the ROS/PPARα/PGC1α Pathway
by: Lixin Du, et al.
Published: (2023-12-01)

Protective effect and pharmacokinetics of dihydromyricetin nanoparticles on oxidative damage of myocardium
by: Lixin Du, et al.
Published: (2024-01-01)

Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats
by: Anwer MK, et al.
Published: (2019-03-01)

PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies
by: Ying Liu, et al.
Published: (2017-01-01)

Ginsenoside Rb1 stabilized and paclitaxel / protopanaxadiol co-loaded nanoparticles for synergistic treatment of breast tumor
by: Likang Lu, et al.
Published: (2023-07-01)

Synthesis of ginsenoside Rb1-imprinted magnetic polymer nanoparticles for the extraction and cellular delivery of therapeutic ginsenosides
by: Kai-Hsi Liu, et al.
Published: (2022-09-01)

Preparation of PLGA Nanoparticles by Milling Spongelike PLGA Microspheres
by: Jimin Lee, et al.
Published: (2022-07-01)

Brain Transport Profiles of Ginsenoside Rb1 by Glucose Transporter 1: In Vitro and in Vivo
by: Yu-Zhu Wang, et al.
Published: (2018-04-01)

Docetaxel-loaded PLGA and PLGA-PEG nanoparticles for intravenous application: pharmacokinetics and biodistribution profile
by: Rafiei P, et al.
Published: (2017-01-01)

Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles
by: Mariia R. Mollaeva, et al.
Published: (2021-11-01)

Progress in the Conversion of Ginsenoside Rb1 into Minor Ginsenosides Using β-Glucosidases
by: Hongrong Zhu, et al.
Published: (2023-01-01)

Effects of Particle Geometry for PLGA-Based Nanoparticles: Preparation and In Vitro/In Vivo Evaluation
by: Meryem Kaplan, et al.
Published: (2023-01-01)

Ginsenoside Rb1 alleviates oxidative damage of HUVECs
by: SONG Zhi-ming, YU Shu-jie, JIAO Jie, LI Ping-ping, LI Hong-mei, QIAN Xiao-xian
Published: (2020-08-01)

Progress of Ginsenoside Rb1 in neurological disorders
by: Gongxia Ling, et al.
Published: (2024-01-01)

Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies
by: Raghuvir H. Gaonkar, et al.
Published: (2017-04-01)

Mannose-decorated ginsenoside Rb1 albumin nanoparticles for targeted anti-inflammatory therapy
by: Zhihui Fu, et al.
Published: (2022-08-01)

Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human beings
by: Min-Koo Choi, et al.
Published: (2020-03-01)

Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection
by: Linkun Hao, et al.
Published: (2021-01-01)

Translational potential of ginsenoside Rb1 in managing progression of osteoarthritis
by: Yuanfeng Chen, et al.
Published: (2016-07-01)

Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin
by: Zainal Abidin, Suhaili
Published: (2013)

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization
by: Elena Sánchez-López, et al.
Published: (2018-03-01)

Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1
by: Hoang Tung Vo, et al.
Published: (2015-10-01)

Preparation and Immune Effect of HEV ORF2 P206@PLGA Nanoparticles
by: Yifei Yang, et al.
Published: (2022-02-01)

Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide
by: Ali Fattahi, et al.
Published: (2019-04-01)

Preparation and characterization of atrazine-loaded biodegradable PLGA nanospheres
by: Xiao-ting CHEN, et al.
Published: (2019-05-01)

Ginsenoside Rb1 Ameliorates Diabetic Arterial Stiffening via AMPK Pathway
by: Xinyu Zhang, et al.
Published: (2021-10-01)

Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content
by: Avgoustakis K, et al.
Published: (2012-03-01)

Myostain is involved in ginsenoside Rb1-mediated anti-obesity
by: Hong-Shi Li, et al.
Published: (2022-12-01)

Preparation, Characterization and Pharmacokinetics of Tolfenamic Acid-Loaded Solid Lipid Nanoparticles
by: Wei Xu, et al.
Published: (2022-09-01)

Production of Gypenoside XVII from Ginsenoside Rb1 by Enzymatic Transformation and Their Anti-Inflammatory Activity In Vitro and In Vivo
by: Kailu Zhou, et al.
Published: (2023-10-01)

Ginsenoside Rb1 protects human vascular smooth muscle cells against resistin-induced oxidative stress and dysfunction
by: Weifeng Lu, et al.
Published: (2023-05-01)

Trastuzumab- and Fab′ fragment-modified curcumin PEG-PLGA nanoparticles: preparation and evaluation in vitro and in vivo
by: Duan D, et al.
Published: (2018-03-01)

Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles
by: Lisa Marinelli, et al.
Published: (2022-08-01)

Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics
by: Peng Dacheng, et al.
Published: (2012-02-01)

Ginsenoside Rb1 improves energy metabolism after spinal cord injury
by: Shan Wen, et al.
Published: (2023-01-01)

Polymorphic Characterization, Pharmacokinetics, and Anti-Inflammatory Activity of Ginsenoside Compound K Polymorphs
by: Yun-Yan Kuang, et al.
Published: (2021-04-01)

Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases
by: Liang Gong, et al.
Published: (2022-06-01)

Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments
by: Chen Chen, et al.
Published: (2019-10-01)

Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles
by: Xiao Que, et al.
Published: (2019-01-01)

Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery
by: Wu, Zhi Min, et al.
Published: (2013)