Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives
The use of sodium 1-(4-amino-5-mercapto-4H-[1,2,4] triazol-3-yl) and heptadecane-1-sulfonate (2) as new precursors to synthesize some important biologically active heterocycles has been found to be effective. The reaction of 2 with carbon disulphide in pyridine and acid chlorides yielded the 1,2,4-t...
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| Format: | Article |
| Language: | English |
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Consejo Superior de Investigaciones Científicas
2006-06-01
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| Series: | Grasas y Aceites |
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| Online Access: | http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/35 |
| _version_ | 1818612623671820288 |
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| author | R. El-Sayed |
| author_facet | R. El-Sayed |
| author_sort | R. El-Sayed |
| collection | DOAJ |
| description | The use of sodium 1-(4-amino-5-mercapto-4H-[1,2,4] triazol-3-yl) and heptadecane-1-sulfonate (2) as new precursors to synthesize some important biologically active heterocycles has been found to be effective. The reaction of 2 with carbon disulphide in pyridine and acid chlorides yielded the 1,2,4-triazole derivatives 3, 4a and 4b.The condensation of 2 with appropriate aldehydes gave 5a-c which were cyclized by treating with thioglycollic acid to yield 6a-c. The reactions of 2 with phthalic anhydride and 4-methylbenzene-sulfonylchloride gave 7 and 8. In addition, the reaction of 2 with chloroacetaldehyde, phenacyl bromide, urea and chloroacetyl chloride yielded 9, 10, 11 and 12. At the same time, refluxing 2 with phenyl isothiocyanate gave 13 and 14. All these products have antimicrobial activity and they can be used as surface active agents. |
| first_indexed | 2024-12-16T15:49:10Z |
| format | Article |
| id | doaj.art-cb9a5e6850d54263bdae49f80410bac0 |
| institution | Directory Open Access Journal |
| issn | 0017-3495 1988-4214 |
| language | English |
| last_indexed | 2024-12-16T15:49:10Z |
| publishDate | 2006-06-01 |
| publisher | Consejo Superior de Investigaciones Científicas |
| record_format | Article |
| series | Grasas y Aceites |
| spelling | doaj.art-cb9a5e6850d54263bdae49f80410bac02022-12-21T22:25:43ZengConsejo Superior de Investigaciones CientíficasGrasas y Aceites0017-34951988-42142006-06-0157218018810.3989/gya.2006.v57.i2.3535Synthesis, antibacterial and surface activity of 1,2,4-triazole derivativesR. El-Sayed0Chemistry Department, Faculty of Science, Benha UnviversityThe use of sodium 1-(4-amino-5-mercapto-4H-[1,2,4] triazol-3-yl) and heptadecane-1-sulfonate (2) as new precursors to synthesize some important biologically active heterocycles has been found to be effective. The reaction of 2 with carbon disulphide in pyridine and acid chlorides yielded the 1,2,4-triazole derivatives 3, 4a and 4b.The condensation of 2 with appropriate aldehydes gave 5a-c which were cyclized by treating with thioglycollic acid to yield 6a-c. The reactions of 2 with phthalic anhydride and 4-methylbenzene-sulfonylchloride gave 7 and 8. In addition, the reaction of 2 with chloroacetaldehyde, phenacyl bromide, urea and chloroacetyl chloride yielded 9, 10, 11 and 12. At the same time, refluxing 2 with phenyl isothiocyanate gave 13 and 14. All these products have antimicrobial activity and they can be used as surface active agents.http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/35124-triazol derivativessynthesisantibacterial propertiessurface activity properties |
| spellingShingle | R. El-Sayed Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives Grasas y Aceites 1 2 4-triazol derivatives synthesis antibacterial properties surface activity properties |
| title | Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives |
| title_full | Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives |
| title_fullStr | Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives |
| title_full_unstemmed | Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives |
| title_short | Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives |
| title_sort | synthesis antibacterial and surface activity of 1 2 4 triazole derivatives |
| topic | 1 2 4-triazol derivatives synthesis antibacterial properties surface activity properties |
| url | http://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/35 |
| work_keys_str_mv | AT relsayed synthesisantibacterialandsurfaceactivityof124triazolederivatives |