Central pontine myelinolysis and extrapontine myelinolysis: literature review and case report
Central pontine myelinolysis (CPM) is a concentrated, symmetric, non-inflammatory demyelination within the central basis pontis. In 10 % of patients with СРМ, demyelination also occurs in extrapontine regions: the mid brain, thalamus, basal nuclei, and cerebellum. Demyelination occurs in regions of...
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2020-09-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/705 |
| _version_ | 1797697565027729408 |
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| author | E. M. Sheveleva L. G. Zaslavskii A. G. Kovelenov E. A. Skorniakova |
| author_facet | E. M. Sheveleva L. G. Zaslavskii A. G. Kovelenov E. A. Skorniakova |
| author_sort | E. M. Sheveleva |
| collection | DOAJ |
| description | Central pontine myelinolysis (CPM) is a concentrated, symmetric, non-inflammatory demyelination within the central basis pontis. In 10 % of patients with СРМ, demyelination also occurs in extrapontine regions: the mid brain, thalamus, basal nuclei, and cerebellum. Demyelination occurs in regions of compact interdigitation of white and gray matter as a result of cellular edema, which is caused by fluctuating osmotic forces, results in compression of fiber tracts. The most frequent cause of abrupt change in osmotic pressure is the rapid sodium correction of prolonged hyponatremia. In case that we report, there is a combination of central pontine and extrapontine myelinolysis, which occurs in 71-year-old woman owing to rapid sodium correction of prolonged hyponatremia which by turn developed due to salt-free diet, improper antihypertensive therapy and overheating. The diagnosis was confirmed by magnetic resonance imaging (MRI). The treatment led to significant decrease of neurological deficit. |
| first_indexed | 2024-03-12T03:42:01Z |
| format | Article |
| id | doaj.art-cb9a9ce9d78844c9a99849250d1da3cf |
| institution | Directory Open Access Journal |
| issn | 1607-4181 |
| language | Russian |
| last_indexed | 2024-03-12T03:42:01Z |
| publishDate | 2020-09-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj.art-cb9a9ce9d78844c9a99849250d1da3cf2023-09-03T13:02:36ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812020-09-01272727810.24884/1607-4181-2020-27-2-72-78510Central pontine myelinolysis and extrapontine myelinolysis: literature review and case reportE. M. Sheveleva0L. G. Zaslavskii1A. G. Kovelenov2E. A. Skorniakova3Pavlov UniversityPavlov University; Leningrad Regional Clinical HospitalLeningrad Regional Clinical HospitalLeningrad Regional Clinical HospitalCentral pontine myelinolysis (CPM) is a concentrated, symmetric, non-inflammatory demyelination within the central basis pontis. In 10 % of patients with СРМ, demyelination also occurs in extrapontine regions: the mid brain, thalamus, basal nuclei, and cerebellum. Demyelination occurs in regions of compact interdigitation of white and gray matter as a result of cellular edema, which is caused by fluctuating osmotic forces, results in compression of fiber tracts. The most frequent cause of abrupt change in osmotic pressure is the rapid sodium correction of prolonged hyponatremia. In case that we report, there is a combination of central pontine and extrapontine myelinolysis, which occurs in 71-year-old woman owing to rapid sodium correction of prolonged hyponatremia which by turn developed due to salt-free diet, improper antihypertensive therapy and overheating. The diagnosis was confirmed by magnetic resonance imaging (MRI). The treatment led to significant decrease of neurological deficit.https://www.sci-notes.ru/jour/article/view/705central pontine myelinolysisextrapontine myelinolysissalt-free dietoverdose of furosemiderapid correction of prolonged hyponatremia |
| spellingShingle | E. M. Sheveleva L. G. Zaslavskii A. G. Kovelenov E. A. Skorniakova Central pontine myelinolysis and extrapontine myelinolysis: literature review and case report Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова central pontine myelinolysis extrapontine myelinolysis salt-free diet overdose of furosemide rapid correction of prolonged hyponatremia |
| title | Central pontine myelinolysis and extrapontine myelinolysis: literature review and case report |
| title_full | Central pontine myelinolysis and extrapontine myelinolysis: literature review and case report |
| title_fullStr | Central pontine myelinolysis and extrapontine myelinolysis: literature review and case report |
| title_full_unstemmed | Central pontine myelinolysis and extrapontine myelinolysis: literature review and case report |
| title_short | Central pontine myelinolysis and extrapontine myelinolysis: literature review and case report |
| title_sort | central pontine myelinolysis and extrapontine myelinolysis literature review and case report |
| topic | central pontine myelinolysis extrapontine myelinolysis salt-free diet overdose of furosemide rapid correction of prolonged hyponatremia |
| url | https://www.sci-notes.ru/jour/article/view/705 |
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