Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus
Abstract Background Type 1 diabetes mellitus (T1DM) is a chronic inflammatory disease concerning insulin-producing β-cells destroyed by the conjoined action of auto reactive T cells, inflammatory cytokines and monocytic cells. Recent proof favors crucial role of cellular autoimmunity as well as its...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2018-10-01
|
| Series: | Bulletin of the National Research Centre |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s42269-018-0016-3 |
| _version_ | 1818695940885708800 |
|---|---|
| author | Weaam Gouda Lamiaa Mageed Soha M. Abd El Dayem Esmat Ashour Mie Afify |
| author_facet | Weaam Gouda Lamiaa Mageed Soha M. Abd El Dayem Esmat Ashour Mie Afify |
| author_sort | Weaam Gouda |
| collection | DOAJ |
| description | Abstract Background Type 1 diabetes mellitus (T1DM) is a chronic inflammatory disease concerning insulin-producing β-cells destroyed by the conjoined action of auto reactive T cells, inflammatory cytokines and monocytic cells. Recent proof favors crucial role of cellular autoimmunity as well as its mediators in pathogenesis and following T1DM. We aimed to investigate whether IL-1α, IL-1β, or IL-10 an easily available inflammatory marker is associated with T1DM. Results The onset of T1DM was accompanied with elevation serum levels of IL-1α, IL-1β, and IL-10. ROC curve revealed that IL10 > 5.95 pg/ml predicted T1DM with sensitivity and specificity of 96% and 90%, respectively. Conclusion The raise of serum inflammatory cytokines such as IL-1α, IL-1β, and IL-10 of the patient may be exploited as potential markers for development of T1DM. The study proposes that level of inflammatory markers is upregulated in T1DM individual in an age-dependent manner and suggesting activation of the inflammatory immune response system. |
| first_indexed | 2024-12-17T13:53:28Z |
| format | Article |
| id | doaj.art-cb9dbffde69e4ace8b28d6c255843540 |
| institution | Directory Open Access Journal |
| issn | 2522-8307 |
| language | English |
| last_indexed | 2024-12-17T13:53:28Z |
| publishDate | 2018-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj.art-cb9dbffde69e4ace8b28d6c2558435402022-12-21T21:46:00ZengSpringerOpenBulletin of the National Research Centre2522-83072018-10-014211610.1186/s42269-018-0016-3Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitusWeaam Gouda0Lamiaa Mageed1Soha M. Abd El Dayem2Esmat Ashour3Mie Afify4Biochemistry Department, National Research CentreBiochemistry Department, National Research CentrePediatric Department, National Research CentreBiochemistry Department, National Research CentreBiochemistry Department, National Research CentreAbstract Background Type 1 diabetes mellitus (T1DM) is a chronic inflammatory disease concerning insulin-producing β-cells destroyed by the conjoined action of auto reactive T cells, inflammatory cytokines and monocytic cells. Recent proof favors crucial role of cellular autoimmunity as well as its mediators in pathogenesis and following T1DM. We aimed to investigate whether IL-1α, IL-1β, or IL-10 an easily available inflammatory marker is associated with T1DM. Results The onset of T1DM was accompanied with elevation serum levels of IL-1α, IL-1β, and IL-10. ROC curve revealed that IL10 > 5.95 pg/ml predicted T1DM with sensitivity and specificity of 96% and 90%, respectively. Conclusion The raise of serum inflammatory cytokines such as IL-1α, IL-1β, and IL-10 of the patient may be exploited as potential markers for development of T1DM. The study proposes that level of inflammatory markers is upregulated in T1DM individual in an age-dependent manner and suggesting activation of the inflammatory immune response system.http://link.springer.com/article/10.1186/s42269-018-0016-3Type 1 diabetes mellitus (T1DM)i Interleukin-1alpha (IL-1α)Interleukin-1beta (IL-1β)Interleukin-10 (IL-10) |
| spellingShingle | Weaam Gouda Lamiaa Mageed Soha M. Abd El Dayem Esmat Ashour Mie Afify Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus Bulletin of the National Research Centre Type 1 diabetes mellitus (T1DM) i Interleukin-1alpha (IL-1α) Interleukin-1beta (IL-1β) Interleukin-10 (IL-10) |
| title | Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus |
| title_full | Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus |
| title_fullStr | Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus |
| title_full_unstemmed | Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus |
| title_short | Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus |
| title_sort | evaluation of pro inflammatory and anti inflammatory cytokines in type 1 diabetes mellitus |
| topic | Type 1 diabetes mellitus (T1DM) i Interleukin-1alpha (IL-1α) Interleukin-1beta (IL-1β) Interleukin-10 (IL-10) |
| url | http://link.springer.com/article/10.1186/s42269-018-0016-3 |
| work_keys_str_mv | AT weaamgouda evaluationofproinflammatoryandantiinflammatorycytokinesintype1diabetesmellitus AT lamiaamageed evaluationofproinflammatoryandantiinflammatorycytokinesintype1diabetesmellitus AT sohamabdeldayem evaluationofproinflammatoryandantiinflammatorycytokinesintype1diabetesmellitus AT esmatashour evaluationofproinflammatoryandantiinflammatorycytokinesintype1diabetesmellitus AT mieafify evaluationofproinflammatoryandantiinflammatorycytokinesintype1diabetesmellitus |