The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population
Abstract We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distrib...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Genética
2018-05-01
|
| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018005008103&lng=en&tlng=en |
| _version_ | 1818064521459138560 |
|---|---|
| author | Ricardo Gamboa Claudia Huesca-Gómez Vanessa López-Pérez Rosalinda Posadas-Sánchez Guillermo Cardoso-Saldaña Aida Medina-Urrutia Juan Gabriel Juárez-Rojas María Elena Soto Carlos Posadas-Romero Gilberto Vargas-Alarcón |
| author_facet | Ricardo Gamboa Claudia Huesca-Gómez Vanessa López-Pérez Rosalinda Posadas-Sánchez Guillermo Cardoso-Saldaña Aida Medina-Urrutia Juan Gabriel Juárez-Rojas María Elena Soto Carlos Posadas-Romero Gilberto Vargas-Alarcón |
| author_sort | Ricardo Gamboa |
| collection | DOAJ |
| description | Abstract We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1.43, Pc = 0.003). On the other hand, patients with pCAD and UCP2 A55V (rs660339) TT showed high levels of visceral abdominal fat (VAF) (Pc = 0.002), low levels of subcutaneous abdominal fat (SAF) (Pc = 0.001) and high VAT/SAT ratio (Pc < 0.001). Also, patients with UCP2 -866 (rs659366) AA showed increased levels of VAF (Pc = 0.003), low levels of SAF (Pc = 0.001) and a high VAT/SAT ratio (Pc = 0.002), whereas patients with the UCP3 -55 (rs1800849) TT presented high levels of VAF (Pc = 0.002). The results suggest the association of the UCP2 -866 (rs659366) polymorphism with risk of developing pCAD. Some polymorphisms were associated with abdominal fat levels and cardiovascular risk factors. |
| first_indexed | 2024-12-10T14:37:19Z |
| format | Article |
| id | doaj.art-cb9e0dd076124872a7d98d9cc693e1e7 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-10T14:37:19Z |
| publishDate | 2018-05-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-cb9e0dd076124872a7d98d9cc693e1e72022-12-22T01:44:47ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852018-05-01010.1590/1678-4685-gmb-2017-0008S1415-47572018005008103The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican populationRicardo GamboaClaudia Huesca-GómezVanessa López-PérezRosalinda Posadas-SánchezGuillermo Cardoso-SaldañaAida Medina-UrrutiaJuan Gabriel Juárez-RojasMaría Elena SotoCarlos Posadas-RomeroGilberto Vargas-AlarcónAbstract We examined the role of UCP gene polymorphisms as susceptibility markers for premature coronary artery disease (pCAD). The UCP2 Ala55Val (C/T rs660339), UCP2 -866G/A (rs659366), and UCP3 -55C/T (rs1800849) polymorphisms were genotyped in 948 patients with pCAD, and 763 controls. The distribution of the UCP2 A55V (C/T rs660339) and UCP3 -55 (rs1800849) was similar in patients and controls. However, under a recessive model, the UCP2 -866 (rs659366) A allele was associated with increased risk of developing pCAD (OR = 1.43, Pc = 0.003). On the other hand, patients with pCAD and UCP2 A55V (rs660339) TT showed high levels of visceral abdominal fat (VAF) (Pc = 0.002), low levels of subcutaneous abdominal fat (SAF) (Pc = 0.001) and high VAT/SAT ratio (Pc < 0.001). Also, patients with UCP2 -866 (rs659366) AA showed increased levels of VAF (Pc = 0.003), low levels of SAF (Pc = 0.001) and a high VAT/SAT ratio (Pc = 0.002), whereas patients with the UCP3 -55 (rs1800849) TT presented high levels of VAF (Pc = 0.002). The results suggest the association of the UCP2 -866 (rs659366) polymorphism with risk of developing pCAD. Some polymorphisms were associated with abdominal fat levels and cardiovascular risk factors.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018005008103&lng=en&tlng=enUCPs polymorphismspremature coronary arterycardiovascular riskMexican population |
| spellingShingle | Ricardo Gamboa Claudia Huesca-Gómez Vanessa López-Pérez Rosalinda Posadas-Sánchez Guillermo Cardoso-Saldaña Aida Medina-Urrutia Juan Gabriel Juárez-Rojas María Elena Soto Carlos Posadas-Romero Gilberto Vargas-Alarcón The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population Genetics and Molecular Biology UCPs polymorphisms premature coronary artery cardiovascular risk Mexican population |
| title | The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population |
| title_full | The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population |
| title_fullStr | The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population |
| title_full_unstemmed | The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population |
| title_short | The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population |
| title_sort | ucp2 866g a ala55val and ucp3 55c t polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in mexican population |
| topic | UCPs polymorphisms premature coronary artery cardiovascular risk Mexican population |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018005008103&lng=en&tlng=en |
| work_keys_str_mv | AT ricardogamboa theucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT claudiahuescagomez theucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT vanessalopezperez theucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT rosalindaposadassanchez theucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT guillermocardososaldana theucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT aidamedinaurrutia theucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT juangabrieljuarezrojas theucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT mariaelenasoto theucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT carlosposadasromero theucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT gilbertovargasalarcon theucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT ricardogamboa ucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT claudiahuescagomez ucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT vanessalopezperez ucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT rosalindaposadassanchez ucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT guillermocardososaldana ucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT aidamedinaurrutia ucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT juangabrieljuarezrojas ucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT mariaelenasoto ucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT carlosposadasromero ucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation AT gilbertovargasalarcon ucp2866gaala55valanducp355ctpolymorphismsareassociatedwithprematurecoronaryarterydiseaseandcardiovascularriskfactorsinmexicanpopulation |