Evaluation of the Repair of Bone Defect after Bone Marrow Stromal Cell Transplantation in Rat
Background & Objective: Bone marrow stromal cells (BMSCs) are multipotent stem cells that can proliferate and differentiate into osteogenic cells . T his study aimed to investigate the effects of BMSC transplantation for the repair of bone defects in the rat. Materials & Methods : Twenty-e...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Fasa University of Medical Sciences
2013-06-01
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| Series: | Journal of Fasa University of Medical Sciences |
| Subjects: | |
| Online Access: | http://journal.fums.ac.ir/browse.php?a_code=A-10-26-38&slc_lang=en&sid=1 |
| Summary: | Background & Objective: Bone marrow stromal cells (BMSCs) are multipotent stem cells that can proliferate and differentiate into osteogenic cells . T his study aimed to investigate the effects of BMSC transplantation for the repair of bone defects in the rat. Materials & Methods : Twenty-eight male adult rats were divided into 4 groups. Group 1 ( control group) received no treatment after the bone defect. In Group 2 ( sham group), the culture medium was injected after the bone defect at the site of the bone defect. In Group 3 non-autologous cell transplantation and in Group 4 autologous cell transplantation were performed in the bone defect. Bone defect repair was evaluated by radiographic and biomechanical testing in all the groups. Results: No significant differences were found between the control group and the Sham group according to radiographic and biomechanical tests. Radiograph bone opacity increased in the autologous and non-autologous group s compared to the control group, but the difference was not significant . Biomechanical results of the bone showed that the mean mechanical strength (Fmax) was significantly increased in the autologous group compared to the control group (p value < 0.05). In addition, mean Fmax was increased in the non-autologous group compared to the control group; the difference, however, did not constitute statistical significance (p value = 0.07). Conclusion: It seems that BMSC transplantation, especially autologous BMSC cell transplantation, exerts positive effects on the repair of the bone defect. |
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| ISSN: | 2228-5105 2228-7329 |