Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries
Context: Cytokine release is a well-known response to surgery especially when it is linked to cancer. Paravertebral block (PVB) is the suitable regional anesthesia for breast surgery. Aim: We tested the effect of replacing general anesthesia (GA) with PVB on cytokine response during and after surger...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Saudi Journal of Anaesthesia |
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| Online Access: | http://www.saudija.org/article.asp?issn=1658-354X;year=2013;volume=7;issue=4;spage=373;epage=377;aulast=Sultan |
| _version_ | 1818154592448282624 |
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| author | Sherif S Sultan |
| author_facet | Sherif S Sultan |
| author_sort | Sherif S Sultan |
| collection | DOAJ |
| description | Context: Cytokine release is a well-known response to surgery especially when it is linked to cancer. Paravertebral block (PVB) is the suitable regional anesthesia for breast surgery. Aim: We tested the effect of replacing general anesthesia (GA) with PVB on cytokine response during and after surgeries for cancer breast. Settings and Design: Controlled randomized study. Methods: Forty cancer breast patients were divided in two groups; Group I received PVB and Group II received GA during performance of unilateral breast surgery without axillary clearance. Plasma concentrations of interleukin (IL)-6, IL-10, IL-12 and interferon-γ (IFN-γ) were measured and IL-10/IFN-γ were estimated in the following points; before starting PVB in Group I or induction of GA in Group II (Sample A), before skin incision (Sample B), at the end of procedure before shifting out of operating room (Sample C), 4-h post-operatively (Sample D) and 24-h post-operatively (Sample E). Statistical Analysis: unpaired Student t-test. Results: IL-6 increased progressively in both groups with statistically significant lower levels in samples C and D in Group I. IL-10 levels showed progressive increasing in both groups without differences between groups. IL-12 showed progressive decrease in both groups with statistically significant higher levels in samples C and D in Group I. IFN-levels showed significantly higher levels in samples C and D in Group I. IL-10/IFN-γ ratio was significantly lower in Group II in samples C and D. Conclusion: Replacing GA with PVB can attenuate cytokines response to cancer breast surgeries. |
| first_indexed | 2024-12-11T14:28:58Z |
| format | Article |
| id | doaj.art-cb9f048981294090844d57ae26da4b59 |
| institution | Directory Open Access Journal |
| issn | 1658-354X |
| language | English |
| last_indexed | 2024-12-11T14:28:58Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Anaesthesia |
| spelling | doaj.art-cb9f048981294090844d57ae26da4b592022-12-22T01:02:33ZengWolters Kluwer Medknow PublicationsSaudi Journal of Anaesthesia1658-354X2013-01-017437337710.4103/1658-354X.121043Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeriesSherif S SultanContext: Cytokine release is a well-known response to surgery especially when it is linked to cancer. Paravertebral block (PVB) is the suitable regional anesthesia for breast surgery. Aim: We tested the effect of replacing general anesthesia (GA) with PVB on cytokine response during and after surgeries for cancer breast. Settings and Design: Controlled randomized study. Methods: Forty cancer breast patients were divided in two groups; Group I received PVB and Group II received GA during performance of unilateral breast surgery without axillary clearance. Plasma concentrations of interleukin (IL)-6, IL-10, IL-12 and interferon-γ (IFN-γ) were measured and IL-10/IFN-γ were estimated in the following points; before starting PVB in Group I or induction of GA in Group II (Sample A), before skin incision (Sample B), at the end of procedure before shifting out of operating room (Sample C), 4-h post-operatively (Sample D) and 24-h post-operatively (Sample E). Statistical Analysis: unpaired Student t-test. Results: IL-6 increased progressively in both groups with statistically significant lower levels in samples C and D in Group I. IL-10 levels showed progressive increasing in both groups without differences between groups. IL-12 showed progressive decrease in both groups with statistically significant higher levels in samples C and D in Group I. IFN-levels showed significantly higher levels in samples C and D in Group I. IL-10/IFN-γ ratio was significantly lower in Group II in samples C and D. Conclusion: Replacing GA with PVB can attenuate cytokines response to cancer breast surgeries.http://www.saudija.org/article.asp?issn=1658-354X;year=2013;volume=7;issue=4;spage=373;epage=377;aulast=SultanCancer breastinterleukinsparavertebral block |
| spellingShingle | Sherif S Sultan Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries Saudi Journal of Anaesthesia Cancer breast interleukins paravertebral block |
| title | Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries |
| title_full | Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries |
| title_fullStr | Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries |
| title_full_unstemmed | Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries |
| title_short | Paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries |
| title_sort | paravertebral block can attenuate cytokine response when it replaces general anesthesia for cancer breast surgeries |
| topic | Cancer breast interleukins paravertebral block |
| url | http://www.saudija.org/article.asp?issn=1658-354X;year=2013;volume=7;issue=4;spage=373;epage=377;aulast=Sultan |
| work_keys_str_mv | AT sherifssultan paravertebralblockcanattenuatecytokineresponsewhenitreplacesgeneralanesthesiaforcancerbreastsurgeries |