Differential blood DNA methylation across Lewy body dementias
Abstract Introduction Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are characterized by cognitive alterations, visual hallucinations, and motor impairment. Diagnosis is based on type and timing of clinical manifestations; however, determination of clinical subtypes is...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12156 |
| _version_ | 1797975549161766912 |
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| author | Chanond A. Nasamran Anubhav Nikunj Singh Sachan Jennifer Mott Yuliya I. Kuras Clemens R. Scherzer Harvard Biomarkers Study Eugenia Ricciardelli Kristen Jepsen Steven D. Edland Kathleen M. Fisch Paula Desplats |
| author_facet | Chanond A. Nasamran Anubhav Nikunj Singh Sachan Jennifer Mott Yuliya I. Kuras Clemens R. Scherzer Harvard Biomarkers Study Eugenia Ricciardelli Kristen Jepsen Steven D. Edland Kathleen M. Fisch Paula Desplats |
| author_sort | Chanond A. Nasamran |
| collection | DOAJ |
| description | Abstract Introduction Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are characterized by cognitive alterations, visual hallucinations, and motor impairment. Diagnosis is based on type and timing of clinical manifestations; however, determination of clinical subtypes is challenging. The utility of blood DNA methylation as a biomarker for Lewy body disorders (LBD) is mostly unexplored. Methods We performed a cross‐sectional analysis of blood methylation in 42 DLB and 50 PDD cases applying linear models to compare groups and logistic least absolute shrinkage and selection operator regression to explore the discriminant power of methylation signals. Results DLB blood shows differential methylation compared to PDD. Some methylation changes associate with core features of LBD. Sets of probes show high predictive value to discriminate between variants. Discussion Our study is the first to explore LBD blood methylation. Despite overlapping clinical presentation, we detected differential epigenetic signatures that, if confirmed in independent cohorts, could be developed into useful biomarkers. |
| first_indexed | 2024-04-11T04:37:18Z |
| format | Article |
| id | doaj.art-cba00624315648c3b7604a8549034eb9 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-11T04:37:18Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-cba00624315648c3b7604a8549034eb92022-12-28T09:12:13ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292021-01-01131n/an/a10.1002/dad2.12156Differential blood DNA methylation across Lewy body dementiasChanond A. Nasamran0Anubhav Nikunj Singh Sachan1Jennifer Mott2Yuliya I. Kuras3Clemens R. Scherzer4Harvard Biomarkers StudyEugenia Ricciardelli5Kristen Jepsen6Steven D. Edland7Kathleen M. Fisch8Paula Desplats9Center for Computational Biology & Bioinformatics Department of Medicine University of California San Diego La Jolla California USADivision of Biostatistics, Department of Family Medicine and Public Health University of California San Diego La Jolla California USADepartment of Neurosciences, School of Medicine University of California San Diego La Jolla California USACenter for Advanced Parkinson Research and Precision Neurology Program, Harvard Medical School Brigham & Women's Hospital Boston Massachusetts USACenter for Advanced Parkinson Research and Precision Neurology Program, Harvard Medical School Brigham & Women's Hospital Boston Massachusetts USAGenomics Center Institute for Genomics Medicine University of California San Diego La Jolla California USAGenomics Center Institute for Genomics Medicine University of California San Diego La Jolla California USADepartment of Neurosciences, School of Medicine University of California San Diego La Jolla California USACenter for Computational Biology & Bioinformatics Department of Medicine University of California San Diego La Jolla California USADepartment of Neurosciences, School of Medicine University of California San Diego La Jolla California USAAbstract Introduction Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are characterized by cognitive alterations, visual hallucinations, and motor impairment. Diagnosis is based on type and timing of clinical manifestations; however, determination of clinical subtypes is challenging. The utility of blood DNA methylation as a biomarker for Lewy body disorders (LBD) is mostly unexplored. Methods We performed a cross‐sectional analysis of blood methylation in 42 DLB and 50 PDD cases applying linear models to compare groups and logistic least absolute shrinkage and selection operator regression to explore the discriminant power of methylation signals. Results DLB blood shows differential methylation compared to PDD. Some methylation changes associate with core features of LBD. Sets of probes show high predictive value to discriminate between variants. Discussion Our study is the first to explore LBD blood methylation. Despite overlapping clinical presentation, we detected differential epigenetic signatures that, if confirmed in independent cohorts, could be developed into useful biomarkers.https://doi.org/10.1002/dad2.12156biomarkerbloodcognitive scoresdementiadementia with Lewy bodies (DLB)DNA methylation |
| spellingShingle | Chanond A. Nasamran Anubhav Nikunj Singh Sachan Jennifer Mott Yuliya I. Kuras Clemens R. Scherzer Harvard Biomarkers Study Eugenia Ricciardelli Kristen Jepsen Steven D. Edland Kathleen M. Fisch Paula Desplats Differential blood DNA methylation across Lewy body dementias Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring biomarker blood cognitive scores dementia dementia with Lewy bodies (DLB) DNA methylation |
| title | Differential blood DNA methylation across Lewy body dementias |
| title_full | Differential blood DNA methylation across Lewy body dementias |
| title_fullStr | Differential blood DNA methylation across Lewy body dementias |
| title_full_unstemmed | Differential blood DNA methylation across Lewy body dementias |
| title_short | Differential blood DNA methylation across Lewy body dementias |
| title_sort | differential blood dna methylation across lewy body dementias |
| topic | biomarker blood cognitive scores dementia dementia with Lewy bodies (DLB) DNA methylation |
| url | https://doi.org/10.1002/dad2.12156 |
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