Patient assessment of 5-fluorouracil and imiquimod for the treatment of actinic keratoses: a retrospective study of real-world effectiveness
Background Despite the superior efficacy of topical therapies for the treatment of actinic keratoses in clinical trials, cryosurgery remains a frequent treatment modality in clinical practice. Little is known about patients’ experience of real-world use of topical therapy. Objective To determine the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-05-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2021.1917758 |
| _version_ | 1797683537198972928 |
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| author | Veronica K. Emmerich Deborah Cull Katherine A. Kelly Steven R. Feldman |
| author_facet | Veronica K. Emmerich Deborah Cull Katherine A. Kelly Steven R. Feldman |
| author_sort | Veronica K. Emmerich |
| collection | DOAJ |
| description | Background Despite the superior efficacy of topical therapies for the treatment of actinic keratoses in clinical trials, cryosurgery remains a frequent treatment modality in clinical practice. Little is known about patients’ experience of real-world use of topical therapy. Objective To determine the real-world effectiveness and tolerability of 5-fluorouracil and imiquimod in the treatment of actinic keratoses. Methods A phone survey and chart review was conducted among 51 patients prescribed 5-fluorouracil (N = 27) or imiquimod (N = 24) for actinic keratoses. Results Six patients (22%) in the 5-fluorouracil group and five patients (21%) in the imiquimod group reported severe local skin reactions, and three patients in both groups (11% and 13%, respectively) were unwilling to use the respective topical therapies again. Patients in the 5-fluorouracil group had, on average, 3.3 fewer cryosurgery spot treatments following topical treatment. Patients in the imiquimod group averaged 2.0 fewer spot treatments. Limitations While this study provides information on real-world experiences, patients’ responses were limited by the ability to recall treatment and potential adverse effects. Conclusion High rates of skin reactions, prolonged discomfort, and the continued need for procedural treatments may make patients less willing to use topical 5-fluorouracil or imiquimod for actinic keratoses. |
| first_indexed | 2024-03-12T00:16:19Z |
| format | Article |
| id | doaj.art-cba2f76a3bc74420b1f108b87ca0523e |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:16:19Z |
| publishDate | 2022-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-cba2f76a3bc74420b1f108b87ca0523e2023-09-15T14:28:50ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-05-013342075207810.1080/09546634.2021.19177581917758Patient assessment of 5-fluorouracil and imiquimod for the treatment of actinic keratoses: a retrospective study of real-world effectivenessVeronica K. Emmerich0Deborah Cull1Katherine A. Kelly2Steven R. Feldman3Department of Dermatology, Center for Dermatology Research, Wake Forest School of MedicineDepartment of Dermatology, Center for Dermatology Research, Wake Forest School of MedicineDepartment of Dermatology, Center for Dermatology Research, Wake Forest School of MedicineDepartment of Dermatology, Center for Dermatology Research, Wake Forest School of MedicineBackground Despite the superior efficacy of topical therapies for the treatment of actinic keratoses in clinical trials, cryosurgery remains a frequent treatment modality in clinical practice. Little is known about patients’ experience of real-world use of topical therapy. Objective To determine the real-world effectiveness and tolerability of 5-fluorouracil and imiquimod in the treatment of actinic keratoses. Methods A phone survey and chart review was conducted among 51 patients prescribed 5-fluorouracil (N = 27) or imiquimod (N = 24) for actinic keratoses. Results Six patients (22%) in the 5-fluorouracil group and five patients (21%) in the imiquimod group reported severe local skin reactions, and three patients in both groups (11% and 13%, respectively) were unwilling to use the respective topical therapies again. Patients in the 5-fluorouracil group had, on average, 3.3 fewer cryosurgery spot treatments following topical treatment. Patients in the imiquimod group averaged 2.0 fewer spot treatments. Limitations While this study provides information on real-world experiences, patients’ responses were limited by the ability to recall treatment and potential adverse effects. Conclusion High rates of skin reactions, prolonged discomfort, and the continued need for procedural treatments may make patients less willing to use topical 5-fluorouracil or imiquimod for actinic keratoses.http://dx.doi.org/10.1080/09546634.2021.1917758actinic keratoses5-fluorouracilimiquimodreal-world effectiveness |
| spellingShingle | Veronica K. Emmerich Deborah Cull Katherine A. Kelly Steven R. Feldman Patient assessment of 5-fluorouracil and imiquimod for the treatment of actinic keratoses: a retrospective study of real-world effectiveness Journal of Dermatological Treatment actinic keratoses 5-fluorouracil imiquimod real-world effectiveness |
| title | Patient assessment of 5-fluorouracil and imiquimod for the treatment of actinic keratoses: a retrospective study of real-world effectiveness |
| title_full | Patient assessment of 5-fluorouracil and imiquimod for the treatment of actinic keratoses: a retrospective study of real-world effectiveness |
| title_fullStr | Patient assessment of 5-fluorouracil and imiquimod for the treatment of actinic keratoses: a retrospective study of real-world effectiveness |
| title_full_unstemmed | Patient assessment of 5-fluorouracil and imiquimod for the treatment of actinic keratoses: a retrospective study of real-world effectiveness |
| title_short | Patient assessment of 5-fluorouracil and imiquimod for the treatment of actinic keratoses: a retrospective study of real-world effectiveness |
| title_sort | patient assessment of 5 fluorouracil and imiquimod for the treatment of actinic keratoses a retrospective study of real world effectiveness |
| topic | actinic keratoses 5-fluorouracil imiquimod real-world effectiveness |
| url | http://dx.doi.org/10.1080/09546634.2021.1917758 |
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