A Calix[8]arene-Based Catalyst for Suzuki–Miyaura Couplings with Reduced Pd_Leaching
Pd-catalysed reactions are amongst the most important in current chemistry. Consequently, very reactive catalysts were developed during the last decades, allowing very high conversions at low catalytic rates. However, decreasing Pd leaching in final products without decreasing catalyst efficiency re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Catalysts |
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| Online Access: | https://www.mdpi.com/2073-4344/12/10/1098 |
| _version_ | 1797474463875334144 |
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| author | Erika Adhel Axel Labattut Timothée Naret Diana Dragoe Vincent Huc |
| author_facet | Erika Adhel Axel Labattut Timothée Naret Diana Dragoe Vincent Huc |
| author_sort | Erika Adhel |
| collection | DOAJ |
| description | Pd-catalysed reactions are amongst the most important in current chemistry. Consequently, very reactive catalysts were developed during the last decades, allowing very high conversions at low catalytic rates. However, decreasing Pd leaching in final products without decreasing catalyst efficiency remains an unsolved issue, especially in the pharma industry. We recently showed that using calixarenes as platforms for Pd-based catalysts constitutes an efficient answer to this concern. In the present work, we show that using these calixarenic platforms in combination with suitably engineered ligands allows for an even more strongly decreased Pd leaching. It thus opens up interesting perspectives for the synthesis of new families of catalysts combining a very high reactivity and a very low Pd leaching in final products. |
| first_indexed | 2024-03-09T20:31:28Z |
| format | Article |
| id | doaj.art-cba5ac6025bc4832b8ddb9ce854fa430 |
| institution | Directory Open Access Journal |
| issn | 2073-4344 |
| language | English |
| last_indexed | 2024-03-09T20:31:28Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Catalysts |
| spelling | doaj.art-cba5ac6025bc4832b8ddb9ce854fa4302023-11-23T23:23:34ZengMDPI AGCatalysts2073-43442022-09-011210109810.3390/catal12101098A Calix[8]arene-Based Catalyst for Suzuki–Miyaura Couplings with Reduced Pd_LeachingErika Adhel0Axel Labattut1Timothée Naret2Diana Dragoe3Vincent Huc4Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), Université Paris-Saclay, Rue du doyen Georges Poitou, FR91405 Orsay, FranceInstitut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), Université Paris-Saclay, Rue du doyen Georges Poitou, FR91405 Orsay, FranceInstitut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), Université Paris-Saclay, Rue du doyen Georges Poitou, FR91405 Orsay, FranceInstitut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), Université Paris-Saclay, Rue du doyen Georges Poitou, FR91405 Orsay, FranceInstitut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO), Université Paris-Saclay, Rue du doyen Georges Poitou, FR91405 Orsay, FrancePd-catalysed reactions are amongst the most important in current chemistry. Consequently, very reactive catalysts were developed during the last decades, allowing very high conversions at low catalytic rates. However, decreasing Pd leaching in final products without decreasing catalyst efficiency remains an unsolved issue, especially in the pharma industry. We recently showed that using calixarenes as platforms for Pd-based catalysts constitutes an efficient answer to this concern. In the present work, we show that using these calixarenic platforms in combination with suitably engineered ligands allows for an even more strongly decreased Pd leaching. It thus opens up interesting perspectives for the synthesis of new families of catalysts combining a very high reactivity and a very low Pd leaching in final products.https://www.mdpi.com/2073-4344/12/10/1098catalysispalladiumcalixarene |
| spellingShingle | Erika Adhel Axel Labattut Timothée Naret Diana Dragoe Vincent Huc A Calix[8]arene-Based Catalyst for Suzuki–Miyaura Couplings with Reduced Pd_Leaching Catalysts catalysis palladium calixarene |
| title | A Calix[8]arene-Based Catalyst for Suzuki–Miyaura Couplings with Reduced Pd_Leaching |
| title_full | A Calix[8]arene-Based Catalyst for Suzuki–Miyaura Couplings with Reduced Pd_Leaching |
| title_fullStr | A Calix[8]arene-Based Catalyst for Suzuki–Miyaura Couplings with Reduced Pd_Leaching |
| title_full_unstemmed | A Calix[8]arene-Based Catalyst for Suzuki–Miyaura Couplings with Reduced Pd_Leaching |
| title_short | A Calix[8]arene-Based Catalyst for Suzuki–Miyaura Couplings with Reduced Pd_Leaching |
| title_sort | calix 8 arene based catalyst for suzuki miyaura couplings with reduced pd leaching |
| topic | catalysis palladium calixarene |
| url | https://www.mdpi.com/2073-4344/12/10/1098 |
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