Increased Heparanase Levels in Urine during Acute Puumala Orthohantavirus Infection Are Associated with Disease Severity

Increased Heparanase Levels in Urine during Acute Puumala Orthohantavirus Infection Are Associated with Disease Severity

Old–world orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS), characterized by acute kidney injury (AKI) with transient proteinuria. It seems plausible that proteinuria during acute HFRS is mediated by the disruption of the glomerular filtration barrier (GFB) due to vascular leakag...

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Bibliographic Details
Main Authors: Luz E. Cabrera, Constanze Schmotz, Moin A. Saleem, Sanna Lehtonen, Olli Vapalahti, Antti Vaheri, Satu Mäkelä, Jukka Mustonen, Tomas Strandin
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Viruses
Subjects:
Puumala hantavirus
acute kidney injury
proteinuria
glycocalyx
podocytes
heparanase
Online Access:https://www.mdpi.com/1999-4915/14/3/450

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