Gastroprotective Effects of <i>Ganoderma lucidum</i> Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats
<i>Ganoderma lucidum</i> is known as a medicine food homology that can ameliorate gastrointestinal diseases. To evaluate the gastroprotective effects on different <i>Ganoderma lucidum</i> polysaccharides (GLPs), GLP was separated into three parts with different molecular weig...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/7/1476 |
| _version_ | 1797438140965715968 |
|---|---|
| author | Baoming Tian Qin Zhao Haoyong Xing Jing Xu Zhenhao Li Hua Zhu Kai Yang Peilong Sun Ming Cai |
| author_facet | Baoming Tian Qin Zhao Haoyong Xing Jing Xu Zhenhao Li Hua Zhu Kai Yang Peilong Sun Ming Cai |
| author_sort | Baoming Tian |
| collection | DOAJ |
| description | <i>Ganoderma lucidum</i> is known as a medicine food homology that can ameliorate gastrointestinal diseases. To evaluate the gastroprotective effects on different <i>Ganoderma lucidum</i> polysaccharides (GLPs), GLP was separated into three parts with different molecular weights using 100 kDa, 10 kDa, and 1 kDa membranes. The mitigation effects of different GLPs on ethanol-induced acute gastric injury were observed in rats. After pretreatment with different GLPs, especially GLP above 10 kDa, the symptoms of gastric mucosal congestion and bleeding were improved; serum myeloperoxidase, inflammatory factor, and histamine were decreased; and antioxidant activity and defense factors (NO and EGF) were increased. Results showed that GLP with different molecular weights had a dose-dependent effect in alleviating alcohol-induced gastric injury. The underlying mechanism might be related to regulating anti-oxidation, promoting the release of related defense factors, reducing inflammatory factors, and reducing the level of histamine in serum. The current work indicated that GLPs above 10 kDa could be applied as natural resources for producing new functional foods to prevent gastric injury induced by ethanol. |
| first_indexed | 2024-03-09T11:32:58Z |
| format | Article |
| id | doaj.art-cba8a72c1bac4114bf2a991e6236c1f0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:32:58Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-cba8a72c1bac4114bf2a991e6236c1f02023-11-30T23:48:47ZengMDPI AGNutrients2072-66432022-04-01147147610.3390/nu14071476Gastroprotective Effects of <i>Ganoderma lucidum</i> Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in RatsBaoming Tian0Qin Zhao1Haoyong Xing2Jing Xu3Zhenhao Li4Hua Zhu5Kai Yang6Peilong Sun7Ming Cai8College of Food Science and Technology, Zhejiang University of Technology, Huzhou 313299, ChinaCollege of Food Science and Technology, Zhejiang University of Technology, Huzhou 313299, ChinaCollege of Food Science and Technology, Zhejiang University of Technology, Huzhou 313299, ChinaLongevity Valley Botanical Co., Ltd., Hangzhou 321200, ChinaLongevity Valley Botanical Co., Ltd., Hangzhou 321200, ChinaCollege of Food Science and Technology, Zhejiang University of Technology, Huzhou 313299, ChinaCollege of Food Science and Technology, Zhejiang University of Technology, Huzhou 313299, ChinaCollege of Food Science and Technology, Zhejiang University of Technology, Huzhou 313299, ChinaCollege of Food Science and Technology, Zhejiang University of Technology, Huzhou 313299, China<i>Ganoderma lucidum</i> is known as a medicine food homology that can ameliorate gastrointestinal diseases. To evaluate the gastroprotective effects on different <i>Ganoderma lucidum</i> polysaccharides (GLPs), GLP was separated into three parts with different molecular weights using 100 kDa, 10 kDa, and 1 kDa membranes. The mitigation effects of different GLPs on ethanol-induced acute gastric injury were observed in rats. After pretreatment with different GLPs, especially GLP above 10 kDa, the symptoms of gastric mucosal congestion and bleeding were improved; serum myeloperoxidase, inflammatory factor, and histamine were decreased; and antioxidant activity and defense factors (NO and EGF) were increased. Results showed that GLP with different molecular weights had a dose-dependent effect in alleviating alcohol-induced gastric injury. The underlying mechanism might be related to regulating anti-oxidation, promoting the release of related defense factors, reducing inflammatory factors, and reducing the level of histamine in serum. The current work indicated that GLPs above 10 kDa could be applied as natural resources for producing new functional foods to prevent gastric injury induced by ethanol.https://www.mdpi.com/2072-6643/14/7/1476<i>Ganoderma lucidum</i> polysaccharidescascade membrane technologyacute alcohol gastric injurygastroprotective effects |
| spellingShingle | Baoming Tian Qin Zhao Haoyong Xing Jing Xu Zhenhao Li Hua Zhu Kai Yang Peilong Sun Ming Cai Gastroprotective Effects of <i>Ganoderma lucidum</i> Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats Nutrients <i>Ganoderma lucidum</i> polysaccharides cascade membrane technology acute alcohol gastric injury gastroprotective effects |
| title | Gastroprotective Effects of <i>Ganoderma lucidum</i> Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats |
| title_full | Gastroprotective Effects of <i>Ganoderma lucidum</i> Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats |
| title_fullStr | Gastroprotective Effects of <i>Ganoderma lucidum</i> Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats |
| title_full_unstemmed | Gastroprotective Effects of <i>Ganoderma lucidum</i> Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats |
| title_short | Gastroprotective Effects of <i>Ganoderma lucidum</i> Polysaccharides with Different Molecular Weights on Ethanol-Induced Acute Gastric Injury in Rats |
| title_sort | gastroprotective effects of i ganoderma lucidum i polysaccharides with different molecular weights on ethanol induced acute gastric injury in rats |
| topic | <i>Ganoderma lucidum</i> polysaccharides cascade membrane technology acute alcohol gastric injury gastroprotective effects |
| url | https://www.mdpi.com/2072-6643/14/7/1476 |
| work_keys_str_mv | AT baomingtian gastroprotectiveeffectsofiganodermalucidumipolysaccharideswithdifferentmolecularweightsonethanolinducedacutegastricinjuryinrats AT qinzhao gastroprotectiveeffectsofiganodermalucidumipolysaccharideswithdifferentmolecularweightsonethanolinducedacutegastricinjuryinrats AT haoyongxing gastroprotectiveeffectsofiganodermalucidumipolysaccharideswithdifferentmolecularweightsonethanolinducedacutegastricinjuryinrats AT jingxu gastroprotectiveeffectsofiganodermalucidumipolysaccharideswithdifferentmolecularweightsonethanolinducedacutegastricinjuryinrats AT zhenhaoli gastroprotectiveeffectsofiganodermalucidumipolysaccharideswithdifferentmolecularweightsonethanolinducedacutegastricinjuryinrats AT huazhu gastroprotectiveeffectsofiganodermalucidumipolysaccharideswithdifferentmolecularweightsonethanolinducedacutegastricinjuryinrats AT kaiyang gastroprotectiveeffectsofiganodermalucidumipolysaccharideswithdifferentmolecularweightsonethanolinducedacutegastricinjuryinrats AT peilongsun gastroprotectiveeffectsofiganodermalucidumipolysaccharideswithdifferentmolecularweightsonethanolinducedacutegastricinjuryinrats AT mingcai gastroprotectiveeffectsofiganodermalucidumipolysaccharideswithdifferentmolecularweightsonethanolinducedacutegastricinjuryinrats |