Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study
Malnutrition has been reported in alcohol use disorder patients as having a possible influence on cognitive function. The aim of this study was to analyse the prevalence of ascorbic acid (AA) deficiency in inpatients admitted for alcohol detoxification and the associated factors, including cognitive...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/12/1892 |
| _version_ | 1797506895600156672 |
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| author | Virgile Clergue-Duval Julien Azuar Julien Fonsart Clément Delage Dorian Rollet Jihed Amami Alexia Frapsauce Marie-Astrid Gautron Eric Hispard Frank Bellivier Vanessa Bloch Jean-Louis Laplanche Frank Questel Florence Vorspan |
| author_facet | Virgile Clergue-Duval Julien Azuar Julien Fonsart Clément Delage Dorian Rollet Jihed Amami Alexia Frapsauce Marie-Astrid Gautron Eric Hispard Frank Bellivier Vanessa Bloch Jean-Louis Laplanche Frank Questel Florence Vorspan |
| author_sort | Virgile Clergue-Duval |
| collection | DOAJ |
| description | Malnutrition has been reported in alcohol use disorder patients as having a possible influence on cognitive function. The aim of this study was to analyse the prevalence of ascorbic acid (AA) deficiency in inpatients admitted for alcohol detoxification and the associated factors, including cognitive impairment in the early period of abstinence. A retrospective chart review was conducted. The AA level was categorised into three groups: deficiency (AAD) (<2 mg/L), insufficiency (AAI) (2–5 mg/L) and normal level. The cognitive impairment was screened using the Montreal Cognitive Assessment (MoCA). Ninety-six patients were included (74 men; mean age 49.1 years (±11.5)). Twenty-seven AAD (28.1%) and twenty-two AAI (22.9%) were observed. In multivariate analysis, risk factors for AAD versus normal AA level were men (OR 17.8, 95%CI (1.63–194)), compensated cirrhosis (OR 9.35, 95%CI (1.60–54.6)) and street homelessness (OR 5.76, 95%CI (1.24–26.8) versus personal housing). The MoCA score was available for 53 patients (mean MoCA score: 25.7 (±3.3)). In multivariate analysis, the natural logarithm of AA (β = 1.18, <i>p</i> = 0.037) and sedative use disorder (β = −2.77, <i>p</i> = 0.046) were associated with the MoCA score. AAD and AAI are frequent in inpatients admitted for alcohol detoxification. A low level of AA was associated with cognitive impairment in the early period of abstinence. |
| first_indexed | 2024-03-10T04:38:57Z |
| format | Article |
| id | doaj.art-cba8c307049f401aa11e935fc4f033d8 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T04:38:57Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-cba8c307049f401aa11e935fc4f033d82023-11-23T03:32:30ZengMDPI AGAntioxidants2076-39212021-11-011012189210.3390/antiox10121892Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot StudyVirgile Clergue-Duval0Julien Azuar1Julien Fonsart2Clément Delage3Dorian Rollet4Jihed Amami5Alexia Frapsauce6Marie-Astrid Gautron7Eric Hispard8Frank Bellivier9Vanessa Bloch10Jean-Louis Laplanche11Frank Questel12Florence Vorspan13APHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, FranceAPHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, FranceAPHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Biochimie et Biologie Moléculaire, 75010 Paris, FranceInserm UMRS-1144 Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris, 75006 Paris, FranceAPHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, FranceAPHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, FranceAPHP GHU Nord, Site Lariboisière Fernand-Widal, Service de Pharmacie, 75010 Paris, FranceFHU Network of Research in Substance Use Disorders (NOR-SUD), 75006 Paris, FranceAPHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, FranceAPHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, FranceInserm UMRS-1144 Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris, 75006 Paris, FranceInserm UMRS-1144 Optimisation Thérapeutique en Neuropsychopharmacologie, Université de Paris, 75006 Paris, FranceAPHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, FranceAPHP GHU Nord, Site Lariboisière Fernand-Widal, Département de Psychiatrie et de Médecine Addictologique, 75010 Paris, FranceMalnutrition has been reported in alcohol use disorder patients as having a possible influence on cognitive function. The aim of this study was to analyse the prevalence of ascorbic acid (AA) deficiency in inpatients admitted for alcohol detoxification and the associated factors, including cognitive impairment in the early period of abstinence. A retrospective chart review was conducted. The AA level was categorised into three groups: deficiency (AAD) (<2 mg/L), insufficiency (AAI) (2–5 mg/L) and normal level. The cognitive impairment was screened using the Montreal Cognitive Assessment (MoCA). Ninety-six patients were included (74 men; mean age 49.1 years (±11.5)). Twenty-seven AAD (28.1%) and twenty-two AAI (22.9%) were observed. In multivariate analysis, risk factors for AAD versus normal AA level were men (OR 17.8, 95%CI (1.63–194)), compensated cirrhosis (OR 9.35, 95%CI (1.60–54.6)) and street homelessness (OR 5.76, 95%CI (1.24–26.8) versus personal housing). The MoCA score was available for 53 patients (mean MoCA score: 25.7 (±3.3)). In multivariate analysis, the natural logarithm of AA (β = 1.18, <i>p</i> = 0.037) and sedative use disorder (β = −2.77, <i>p</i> = 0.046) were associated with the MoCA score. AAD and AAI are frequent in inpatients admitted for alcohol detoxification. A low level of AA was associated with cognitive impairment in the early period of abstinence.https://www.mdpi.com/2076-3921/10/12/1892ascorbic acidcognitive impairmentalcohol use disordermalnutritioncentral nervous systemsedative use disorder |
| spellingShingle | Virgile Clergue-Duval Julien Azuar Julien Fonsart Clément Delage Dorian Rollet Jihed Amami Alexia Frapsauce Marie-Astrid Gautron Eric Hispard Frank Bellivier Vanessa Bloch Jean-Louis Laplanche Frank Questel Florence Vorspan Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study Antioxidants ascorbic acid cognitive impairment alcohol use disorder malnutrition central nervous system sedative use disorder |
| title | Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study |
| title_full | Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study |
| title_fullStr | Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study |
| title_full_unstemmed | Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study |
| title_short | Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study |
| title_sort | ascorbic acid deficiency prevalence and associated cognitive impairment in alcohol detoxification inpatients a pilot study |
| topic | ascorbic acid cognitive impairment alcohol use disorder malnutrition central nervous system sedative use disorder |
| url | https://www.mdpi.com/2076-3921/10/12/1892 |
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