Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2

Yeast gene KTI13 (alias DPH8) operates in the initiation step of diphthamide synthesis on elongation factor 2

In yeast, Elongator-dependent tRNA modifications are regulated by the Kti11•Kti13 dimer and hijacked for cell killing by zymocin, a tRNase ribotoxin. Kti11 (alias Dph3) also controls modification of elongation factor 2 (EF2) with diphthamide, the target for lethal ADP-ribosylation by diphtheria toxi...

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Bibliographic Details
Main Authors: Meike Arend, Koray Ütkür, Harmen Hawer, Klaus Mayer, Namit Ranjan, Lorenz Adrian, Ulrich Brinkmann, Raffael Schaffrath
Format: Article
Language:English
Published: Shared Science Publishers OG 2022-08-01
Series:Microbial Cell
Subjects:
budding yeast
ef2 diphthamide modification
diphtheria toxin
trna modification
elongator
trnase zymocin
Online Access:http://microbialcell.com/researcharticles/2023a-arend-microbial-cell/

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http://microbialcell.com/researcharticles/2023a-arend-microbial-cell/

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