ANALYSIS OF THE DYNAMICS OF UROPATHOGENS ANTIMICROBIAL RESISTANCE IN PATIENTS OF MULTI-SPECIALTY HOSPITAL
Urinary tract infections are among the most common bacterial infections. Currently, one of the main problems of therapy, as for the infections of other localizations, is the high level of antibiotic resistance. Timely prescribed and adequately selected antimicrobial therapy is the main factor determ...
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| Format: | Article |
| Language: | English |
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Ministry of Health of the Russian Federation, Irkutsk State Medical University
2023-12-01
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| Series: | Байкальский медицинский журнал |
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| Online Access: | https://www.bmjour.ru/jour/article/view/127 |
| _version_ | 1797370668598165504 |
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| author | Natalia A. Dvoynikova Natalya Yu. Alekseeva Ivan D. Zarva |
| author_facet | Natalia A. Dvoynikova Natalya Yu. Alekseeva Ivan D. Zarva |
| author_sort | Natalia A. Dvoynikova |
| collection | DOAJ |
| description | Urinary tract infections are among the most common bacterial infections. Currently, one of the main problems of therapy, as for the infections of other localizations, is the high level of antibiotic resistance. Timely prescribed and adequately selected antimicrobial therapy is the main factor determining the treatment outcome.The aim of the study. To carry out dynamic analysis of the etiological structure of urinary tract microflora and to assess antibiotic resistance of the most significant uropathogens in patients of the Clinics of the Irkutsk State Medical University (Clinics of ISMU) in order to optimize the use of antimicrobial drugs in a multidisciplinary hospital.Materials and methods. We analyzed bacterial strains (n = 2414) collected from urine of patients treated at the Clin-ics of ISMU from 2018 to 2022. Microbiological examination of urine was conducted in bacteriological laboratory of the Clinics of ISMU.Results. During the study period, E. coli remained the main uropathogen. There has been an increase in antibiotic resistance of E. coli to the main antimicrobial agents which are traditionally used to treat urinary tract infections, including fluoroquinolones and third-generation cephalosporins. There is an increase in the frequency of detection of E. coli strains producing extended-spectrum b-lactamases from 5.4 % to 12.4 %. Meropenem and nitrofurantoin retain the greatest activity against E. coli.Conclusion. The results of this study indicate the need to strengthen control over the use of antimicrobial agents in medical organizations, the importance of constant microbiological monitoring in order to identify the characteristics of local antibiotic resistance and update protocols for empirical treatment of urinary tract infections. |
| first_indexed | 2024-03-08T18:07:53Z |
| format | Article |
| id | doaj.art-cbabbb75d28349f1a4166a10e712c692 |
| institution | Directory Open Access Journal |
| issn | 2949-0715 |
| language | English |
| last_indexed | 2024-03-08T18:07:53Z |
| publishDate | 2023-12-01 |
| publisher | Ministry of Health of the Russian Federation, Irkutsk State Medical University |
| record_format | Article |
| series | Байкальский медицинский журнал |
| spelling | doaj.art-cbabbb75d28349f1a4166a10e712c6922024-01-01T12:18:06ZengMinistry of Health of the Russian Federation, Irkutsk State Medical UniversityБайкальский медицинский журнал2949-07152023-12-0124455210.57256/2949-0715-2023-4-45-52103ANALYSIS OF THE DYNAMICS OF UROPATHOGENS ANTIMICROBIAL RESISTANCE IN PATIENTS OF MULTI-SPECIALTY HOSPITALNatalia A. Dvoynikova0Natalya Yu. Alekseeva1Ivan D. Zarva2ФГБОУ ВО ИГМУ Минздрава РоссииФГБОУ ВО Иркутский государственный медицинский университет Минздрава РоссииФГБОУ ВО Иркутский государственный медицинский университет Минздрава РоссииUrinary tract infections are among the most common bacterial infections. Currently, one of the main problems of therapy, as for the infections of other localizations, is the high level of antibiotic resistance. Timely prescribed and adequately selected antimicrobial therapy is the main factor determining the treatment outcome.The aim of the study. To carry out dynamic analysis of the etiological structure of urinary tract microflora and to assess antibiotic resistance of the most significant uropathogens in patients of the Clinics of the Irkutsk State Medical University (Clinics of ISMU) in order to optimize the use of antimicrobial drugs in a multidisciplinary hospital.Materials and methods. We analyzed bacterial strains (n = 2414) collected from urine of patients treated at the Clin-ics of ISMU from 2018 to 2022. Microbiological examination of urine was conducted in bacteriological laboratory of the Clinics of ISMU.Results. During the study period, E. coli remained the main uropathogen. There has been an increase in antibiotic resistance of E. coli to the main antimicrobial agents which are traditionally used to treat urinary tract infections, including fluoroquinolones and third-generation cephalosporins. There is an increase in the frequency of detection of E. coli strains producing extended-spectrum b-lactamases from 5.4 % to 12.4 %. Meropenem and nitrofurantoin retain the greatest activity against E. coli.Conclusion. The results of this study indicate the need to strengthen control over the use of antimicrobial agents in medical organizations, the importance of constant microbiological monitoring in order to identify the characteristics of local antibiotic resistance and update protocols for empirical treatment of urinary tract infections.https://www.bmjour.ru/jour/article/view/127antimicrobial agents, antimicrobial resistance, microbiological monitoring, urinary tract infections |
| spellingShingle | Natalia A. Dvoynikova Natalya Yu. Alekseeva Ivan D. Zarva ANALYSIS OF THE DYNAMICS OF UROPATHOGENS ANTIMICROBIAL RESISTANCE IN PATIENTS OF MULTI-SPECIALTY HOSPITAL Байкальский медицинский журнал antimicrobial agents, antimicrobial resistance, microbiological monitoring, urinary tract infections |
| title | ANALYSIS OF THE DYNAMICS OF UROPATHOGENS ANTIMICROBIAL RESISTANCE IN PATIENTS OF MULTI-SPECIALTY HOSPITAL |
| title_full | ANALYSIS OF THE DYNAMICS OF UROPATHOGENS ANTIMICROBIAL RESISTANCE IN PATIENTS OF MULTI-SPECIALTY HOSPITAL |
| title_fullStr | ANALYSIS OF THE DYNAMICS OF UROPATHOGENS ANTIMICROBIAL RESISTANCE IN PATIENTS OF MULTI-SPECIALTY HOSPITAL |
| title_full_unstemmed | ANALYSIS OF THE DYNAMICS OF UROPATHOGENS ANTIMICROBIAL RESISTANCE IN PATIENTS OF MULTI-SPECIALTY HOSPITAL |
| title_short | ANALYSIS OF THE DYNAMICS OF UROPATHOGENS ANTIMICROBIAL RESISTANCE IN PATIENTS OF MULTI-SPECIALTY HOSPITAL |
| title_sort | analysis of the dynamics of uropathogens antimicrobial resistance in patients of multi specialty hospital |
| topic | antimicrobial agents, antimicrobial resistance, microbiological monitoring, urinary tract infections |
| url | https://www.bmjour.ru/jour/article/view/127 |
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