The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis
Both fibrosis and cirrhosis of the liver are the end results of most kinds of chronic liver damage and represent a common but difficult clinical challenge throughout the world. The inhibition of the fibrogenic, proliferative, and migratory effects of hepatic stellate cells (HSCs) has become an exper...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/7/1889 |
| _version_ | 1811300898244132864 |
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| author | Ying-Hsien Huang Ya-Ling Yang Feng-Sheng Wang |
| author_facet | Ying-Hsien Huang Ya-Ling Yang Feng-Sheng Wang |
| author_sort | Ying-Hsien Huang |
| collection | DOAJ |
| description | Both fibrosis and cirrhosis of the liver are the end results of most kinds of chronic liver damage and represent a common but difficult clinical challenge throughout the world. The inhibition of the fibrogenic, proliferative, and migratory effects of hepatic stellate cells (HSCs) has become an experimental therapy for preventing and even reversing hepatic fibrosis. Furthermore, a complete understanding of the function of non-coding RNA-mediated epigenetic mechanisms in HSC activation may improve our perception of liver fibrosis pathogenesis. This review focuses on the evolving view of the molecular mechanisms by which HSC activation by miR-29a signaling may moderate the profibrogenic phenotype of these cells, thus supporting the use of miR-29a agonists as a potential therapy for treating liver fibrosis in the future. |
| first_indexed | 2024-04-13T06:58:10Z |
| format | Article |
| id | doaj.art-cbac7dbf5f1b4f298fc78c775dc6e991 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T06:58:10Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cbac7dbf5f1b4f298fc78c775dc6e9912022-12-22T02:57:11ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-06-01197188910.3390/ijms19071889ijms19071889The Role of miR-29a in the Regulation, Function, and Signaling of Liver FibrosisYing-Hsien Huang0Ya-Ling Yang1Feng-Sheng Wang2Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanCore Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanBoth fibrosis and cirrhosis of the liver are the end results of most kinds of chronic liver damage and represent a common but difficult clinical challenge throughout the world. The inhibition of the fibrogenic, proliferative, and migratory effects of hepatic stellate cells (HSCs) has become an experimental therapy for preventing and even reversing hepatic fibrosis. Furthermore, a complete understanding of the function of non-coding RNA-mediated epigenetic mechanisms in HSC activation may improve our perception of liver fibrosis pathogenesis. This review focuses on the evolving view of the molecular mechanisms by which HSC activation by miR-29a signaling may moderate the profibrogenic phenotype of these cells, thus supporting the use of miR-29a agonists as a potential therapy for treating liver fibrosis in the future.http://www.mdpi.com/1422-0067/19/7/1889miR-29acholestasisapoptosisendoplasmic reticulum stresstoll-like receptorsepigenetics |
| spellingShingle | Ying-Hsien Huang Ya-Ling Yang Feng-Sheng Wang The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis International Journal of Molecular Sciences miR-29a cholestasis apoptosis endoplasmic reticulum stress toll-like receptors epigenetics |
| title | The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis |
| title_full | The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis |
| title_fullStr | The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis |
| title_full_unstemmed | The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis |
| title_short | The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis |
| title_sort | role of mir 29a in the regulation function and signaling of liver fibrosis |
| topic | miR-29a cholestasis apoptosis endoplasmic reticulum stress toll-like receptors epigenetics |
| url | http://www.mdpi.com/1422-0067/19/7/1889 |
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