HIV-1 Persistence in Children during Suppressive ART
There is a growing number of perinatally HIV-1-infected children worldwide who must maintain life-long ART. In early life, HIV-1 infection is established in an immunologically inexperienced environment in which maternal ART and immune dynamics during pregnancy play a role in reservoir establishment....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/6/1134 |
| _version_ | 1797530355700334592 |
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| author | Mary Grace Katusiime Gert U. Van Zyl Mark F. Cotton Mary F. Kearney |
| author_facet | Mary Grace Katusiime Gert U. Van Zyl Mark F. Cotton Mary F. Kearney |
| author_sort | Mary Grace Katusiime |
| collection | DOAJ |
| description | There is a growing number of perinatally HIV-1-infected children worldwide who must maintain life-long ART. In early life, HIV-1 infection is established in an immunologically inexperienced environment in which maternal ART and immune dynamics during pregnancy play a role in reservoir establishment. Children that initiated early antiretroviral therapy (ART) and maintained long-term suppression of viremia have smaller and less diverse HIV reservoirs than adults, although their proviral landscape during ART is reported to be similar to that of adults. The ability of these early infected cells to persist long-term through clonal expansion poses a major barrier to finding a cure. Furthermore, the effects of life-long HIV persistence and ART are yet to be understood, but growing evidence suggests that these individuals are at an increased risk for developing non-AIDS-related comorbidities, which underscores the need for an HIV cure. |
| first_indexed | 2024-03-10T10:27:44Z |
| format | Article |
| id | doaj.art-cbacd829ed6446989be258ff24f0800c |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:27:44Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-cbacd829ed6446989be258ff24f0800c2023-11-21T23:53:21ZengMDPI AGViruses1999-49152021-06-01136113410.3390/v13061134HIV-1 Persistence in Children during Suppressive ARTMary Grace Katusiime0Gert U. Van Zyl1Mark F. Cotton2Mary F. Kearney3HIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, MD 21702, USADivision of Medical Virology, Stellenbosch University and National Health Laboratory Service Tygerberg, Cape Town 8000, South AfricaDepartment of Pediatrics and Child Health, Tygerberg Children’s Hospital and Family Center for Research with Ubuntu, Stellenbosch University, Cape Town 7505, South AfricaHIV Dynamics and Replication Program, CCR, National Cancer Institute, Frederick, MD 21702, USAThere is a growing number of perinatally HIV-1-infected children worldwide who must maintain life-long ART. In early life, HIV-1 infection is established in an immunologically inexperienced environment in which maternal ART and immune dynamics during pregnancy play a role in reservoir establishment. Children that initiated early antiretroviral therapy (ART) and maintained long-term suppression of viremia have smaller and less diverse HIV reservoirs than adults, although their proviral landscape during ART is reported to be similar to that of adults. The ability of these early infected cells to persist long-term through clonal expansion poses a major barrier to finding a cure. Furthermore, the effects of life-long HIV persistence and ART are yet to be understood, but growing evidence suggests that these individuals are at an increased risk for developing non-AIDS-related comorbidities, which underscores the need for an HIV cure.https://www.mdpi.com/1999-4915/13/6/1134HIV-1 persistenceperinatal HIV-1HIV-1 reservoirschildrenlong-term ART |
| spellingShingle | Mary Grace Katusiime Gert U. Van Zyl Mark F. Cotton Mary F. Kearney HIV-1 Persistence in Children during Suppressive ART Viruses HIV-1 persistence perinatal HIV-1 HIV-1 reservoirs children long-term ART |
| title | HIV-1 Persistence in Children during Suppressive ART |
| title_full | HIV-1 Persistence in Children during Suppressive ART |
| title_fullStr | HIV-1 Persistence in Children during Suppressive ART |
| title_full_unstemmed | HIV-1 Persistence in Children during Suppressive ART |
| title_short | HIV-1 Persistence in Children during Suppressive ART |
| title_sort | hiv 1 persistence in children during suppressive art |
| topic | HIV-1 persistence perinatal HIV-1 HIV-1 reservoirs children long-term ART |
| url | https://www.mdpi.com/1999-4915/13/6/1134 |
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