Rapid evaluation of mesenchymal stem cell injection technology on the treatment of cerebral palsy: a review study
Background: Cerebral palsy is a movement disorder syndrome in early childhood. Signs and symptoms vary among people and over time but include poor coordination, stiff muscles, and weak muscles. Some affected children can achieve near-normal adult lives with appropriate treatment. In recent years, tr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2022-12-01
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| Series: | Tehran University Medical Journal |
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| Online Access: | http://tumj.tums.ac.ir/article-1-12111-en.html |
| _version_ | 1797840302697873408 |
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| author | Mohsen Barouni Zohreh Shaker Zinab Shaker Asma Sabermahani |
| author_facet | Mohsen Barouni Zohreh Shaker Zinab Shaker Asma Sabermahani |
| author_sort | Mohsen Barouni |
| collection | DOAJ |
| description | Background: Cerebral palsy is a movement disorder syndrome in early childhood. Signs and symptoms vary among people and over time but include poor coordination, stiff muscles, and weak muscles. Some affected children can achieve near-normal adult lives with appropriate treatment. In recent years, transplantation of human mesenchymal stem cells (hMSC) has become a promising therapeutic strategy for CP. Every year, a lot of costs are spent on the treatment and management of this disease. The purpose of this study is to investigate the safety and effectiveness of this method on CP.
Methods: This article is a systematic review. At first, a search strategy was written and performed in Scopus, PubMed, and Google Scholar databases(The search was conducted from March 14 to March 28, 2021), and the inclusion and exclusion criteria were determined. Study inclusion criteria: review studies, cohort studies, clinical trial studies (randomized and non-randomized), control case, and retrospective , exclusion criteria: non-English articles and studying on animals. After removing duplicate articles, two authors independently reviewed the studies according to the inclusion and exclusion criteria. Disagreements among the authors were resolved through discussion.
Findings: In total, 9236 articles were found in the initial search, after reading the titles, of 37 articles, 21 articles were selected in the abstract stage and 18 articles remained in the full-text stage. We finally found 18 articles that showed that using stem cell technology as a scientific method could improve sick patients’ quality of life and movement defects.
Conclusion: According to the available evidence and limited studies, stem cell technology can be safeand cost-effective in improving CP patients, but there is insufficient evidence. On the other hand, there are many studies confirming the effectiveness of these cells in the treatment of movement impairment. In conclusion, stem cells may have a very promising future. Finally, stem cell technology combined with innovative biotechnologies may soon bring promising results to patients. |
| first_indexed | 2024-04-09T16:12:45Z |
| format | Article |
| id | doaj.art-cbaf20ba30c24bc48f6f92778aee40fb |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-04-09T16:12:45Z |
| publishDate | 2022-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-cbaf20ba30c24bc48f6f92778aee40fb2023-04-24T08:34:37ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222022-12-018010760770Rapid evaluation of mesenchymal stem cell injection technology on the treatment of cerebral palsy: a review studyMohsen Barouni0Zohreh Shaker1Zinab Shaker2Asma Sabermahani3 Department of in Health Economics, Health Services Management Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. Health Human Resources Research Center, School of Health Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Department of in Health Economics, Faculty of Management and Medical Information Sciences, Kerman University of Medical Sciences, Kerman, Iran. Department of in Health Economics, Faculty of Management and Medical Information Sciences, Kerman University of Medical Sciences, Kerman, Iran. Background: Cerebral palsy is a movement disorder syndrome in early childhood. Signs and symptoms vary among people and over time but include poor coordination, stiff muscles, and weak muscles. Some affected children can achieve near-normal adult lives with appropriate treatment. In recent years, transplantation of human mesenchymal stem cells (hMSC) has become a promising therapeutic strategy for CP. Every year, a lot of costs are spent on the treatment and management of this disease. The purpose of this study is to investigate the safety and effectiveness of this method on CP. Methods: This article is a systematic review. At first, a search strategy was written and performed in Scopus, PubMed, and Google Scholar databases(The search was conducted from March 14 to March 28, 2021), and the inclusion and exclusion criteria were determined. Study inclusion criteria: review studies, cohort studies, clinical trial studies (randomized and non-randomized), control case, and retrospective , exclusion criteria: non-English articles and studying on animals. After removing duplicate articles, two authors independently reviewed the studies according to the inclusion and exclusion criteria. Disagreements among the authors were resolved through discussion. Findings: In total, 9236 articles were found in the initial search, after reading the titles, of 37 articles, 21 articles were selected in the abstract stage and 18 articles remained in the full-text stage. We finally found 18 articles that showed that using stem cell technology as a scientific method could improve sick patients’ quality of life and movement defects. Conclusion: According to the available evidence and limited studies, stem cell technology can be safeand cost-effective in improving CP patients, but there is insufficient evidence. On the other hand, there are many studies confirming the effectiveness of these cells in the treatment of movement impairment. In conclusion, stem cells may have a very promising future. Finally, stem cell technology combined with innovative biotechnologies may soon bring promising results to patients.http://tumj.tums.ac.ir/article-1-12111-en.htmlcerebral palsyeffectivenessmesenchymal stem cellssafety. |
| spellingShingle | Mohsen Barouni Zohreh Shaker Zinab Shaker Asma Sabermahani Rapid evaluation of mesenchymal stem cell injection technology on the treatment of cerebral palsy: a review study Tehran University Medical Journal cerebral palsy effectiveness mesenchymal stem cells safety. |
| title | Rapid evaluation of mesenchymal stem cell injection technology on the treatment of cerebral palsy: a review study |
| title_full | Rapid evaluation of mesenchymal stem cell injection technology on the treatment of cerebral palsy: a review study |
| title_fullStr | Rapid evaluation of mesenchymal stem cell injection technology on the treatment of cerebral palsy: a review study |
| title_full_unstemmed | Rapid evaluation of mesenchymal stem cell injection technology on the treatment of cerebral palsy: a review study |
| title_short | Rapid evaluation of mesenchymal stem cell injection technology on the treatment of cerebral palsy: a review study |
| title_sort | rapid evaluation of mesenchymal stem cell injection technology on the treatment of cerebral palsy a review study |
| topic | cerebral palsy effectiveness mesenchymal stem cells safety. |
| url | http://tumj.tums.ac.ir/article-1-12111-en.html |
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