Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in miceResearch in context

Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in miceResearch in context

Summary: Background: Schizophrenia, a debilitating psychiatric disorder, displays considerable interindividual variation in clinical presentations. The ongoing debate revolves around whether this heterogeneity signifies a continuum of severity linked to a singular causative factor or a collection o...

Full description

Bibliographic Details
Main Authors:	Yi Lu, Longyu Mu, Justin Elstrott, Chaoying Fu, Cailu Sun, Tonghui Su, Xiaofan Ma, Jia Yan, Hong Jiang, Jesse E. Hanson, Yang Geng, Yelin Chen
Format:	Article
Language:	English
Published:	Elsevier 2024-04-01
Series:	EBioMedicine
Subjects:	NMDA receptor GluN2A Schizophrenia Conditional knockout mouse Medial prefrontal cortex Excitatory synaptic transmission
Online Access:	http://www.sciencedirect.com/science/article/pii/S235239642400080X

Similar Items

Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia
by: Chitra Vinnakota, et al.
Published: (2023-07-01)

GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses
by: Justinas J. Dainauskas, et al.
Published: (2023-03-01)

GluN2B-containing NMDARs in the mammalian brain: pharmacology, physiology, and pathology
by: Yang Ge, et al.
Published: (2023-05-01)

Genetic deletion of GluN3A affects depression-like behaviors and mRNA transcriptome in medial prefrontal cortex and hippocampus in mice
by: ZHANG Mengmeng, et al.
Published: (2023-08-01)

N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease
by: Xiong Wang, et al.
Published: (2023-11-01)

Anticonvulsant Action of GluN2A-Preferring Antagonist PEAQX in Developing Rats
by: Pavel Mares, et al.
Published: (2021-03-01)

GluN2A and GluN2B N-Methyl-D-Aspartate Receptor (NMDARs) Subunits: Their Roles and Therapeutic Antagonists in Neurological Diseases
by: Amany Digal Ladagu, et al.
Published: (2023-10-01)

Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands (11C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors
by: Lisheng Cai, et al.
Published: (2023-04-01)

NX210c Peptide Promotes Glutamatergic Receptor-Mediated Synaptic Transmission and Signaling in the Mouse Central Nervous System
by: Sighild Lemarchant, et al.
Published: (2022-08-01)

Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer’s disease
by: Shan P. Yu, et al.
Published: (2023-07-01)

Development and Validation of [<sup>3</sup>H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs
by: Hazem Ahmed, et al.
Published: (2022-08-01)

Altered synaptic plasticity at hippocampal CA1–CA3 synapses in Alzheimer's disease: integration of amyloid precursor protein intracellular domain and amyloid beta effects into computational models
by: Justinas J. Dainauskas, et al.
Published: (2023-12-01)

GluN2B-containing NMDA receptor attenuated neuronal apoptosis in the mouse model of HIBD through inhibiting endoplasmic reticulum stress-activated PERK/eIF2α signaling pathway
by: Mengxue Wu, et al.
Published: (2024-04-01)

Inhibition of NMDA Receptor Activation in the Rostral Ventrolateral Medulla by Amyloid-β Peptide in Rats
by: Md Sharyful Islam, et al.
Published: (2023-12-01)

The GluN2B-Selective Antagonist Ro 25-6981 Is Effective against PTZ-Induced Seizures and Safe for Further Development in Infantile Rats
by: Pavel Mareš, et al.
Published: (2021-09-01)

A Conantokin Peptide Con-T[M8Q] Inhibits Morphine Dependence with High Potency and Low Side Effects
by: Zhuguo Liu, et al.
Published: (2021-01-01)

How Are Synapses Born? A Functional and Molecular View of the Role of the Wnt Signaling Pathway
by: Christian Bonansco, et al.
Published: (2022-12-01)

Sex differences in the medial prefrontal cortical glutamate system
by: Melissa C. Knouse, et al.
Published: (2022-11-01)

Restored Fyn Levels in Huntington’s Disease Contributes to Enhanced Synaptic GluN2B-Composed NMDA Receptors and CREB Activity
by: Lígia Fão, et al.
Published: (2022-09-01)

GluN2A Mediates PS-Induced Depressive-Like Behavior by Activating CaMKII and Inhibiting Myelinization
by: Huimei Huang, et al.
Published: (2023-12-01)

Neuromodulation Using Transcranial Focused Ultrasound on the Bilateral Medial Prefrontal Cortex
by: Young Goo Kim, et al.
Published: (2022-06-01)

Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments
by: Hristo Varbanov, et al.
Published: (2023-05-01)

Phosphorylation Status of GluN2B-Ser1303 Under Glutamate-induced Excitotoxicity in Primary Cortical Neurons: An In Vitro Study
by: Ramya R Prabhu
Published: (2023-10-01)

Insertion of Calcium-Permeable AMPA Receptors during Epileptiform Activity In Vitro Modulates Excitability of Principal Neurons in the Rat Entorhinal Cortex
by: Dmitry V. Amakhin, et al.
Published: (2021-11-01)

Identification of homologous GluN subunits variants accelerates GRIN variants stratification
by: Ana Santos-Gómez, et al.
Published: (2022-12-01)

Myelinating Co-Culture as a Model to Study Anti-NMDAR Neurotoxicity
by: Mercedeh Farhat Sabet, et al.
Published: (2022-12-01)

Parvalbumin expression and gamma oscillation occurrence increase over time in a neurodevelopmental model of NMDA receptor dysfunction
by: Ben van Lier, et al.
Published: (2018-09-01)

GluN2 Subunit-Dependent Redox Modulation of NMDA Receptor Activation by Homocysteine
by: Dmitry A. Sibarov, et al.
Published: (2020-10-01)

Targeted NMDA Receptor Interventions for Autism: Developmentally Determined Expression of GluN2B and GluN2A-Containing Receptors and Balanced Allosteric Modulatory Approaches
by: Stephen I. Deutsch, et al.
Published: (2022-01-01)

Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice
by: Junjie Li, et al.
Published: (2023-05-01)

Updates on the Physiopathology of Group I Metabotropic Glutamate Receptors (mGluRI)-Dependent Long-Term Depression
by: Dalila Mango, et al.
Published: (2023-06-01)

Prefrontal cortex glutamatergic adaptations in a mouse model of alcohol use disorder
by: Mahum T. Siddiqi, et al.
Published: (2023-12-01)

Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I
by: Graham M. Pitcher, et al.
Published: (2023-07-01)

Ser-Thr phosphatases in the rat brain that dephosphorylate phospho-Ser(1291)-GluN2A subunit of glutamate receptor
by: R. R. Prabhu
Published: (2023-08-01)

Modification of the synaptic cleft under excitatory conditions
by: Jung-Hwa Tao-Cheng, et al.
Published: (2023-09-01)

Deformability of Glued Laminated Beams with Combined Reinforcement
by: Justyna Sobczak-Piąstka, et al.
Published: (2020-05-01)

Binding and Dynamics Demonstrate the Destabilization of Ligand Binding for the S688Y Mutation in the NMDA Receptor GluN1 Subunit
by: Jake Zheng Chen, et al.
Published: (2023-05-01)

GRIN2B-related neurodevelopmental disorder: current understanding of pathophysiological mechanisms
by: Shasta L. Sabo, et al.
Published: (2023-01-01)

Physicochemical principles of gluing and adhesion processes /
by: 237489 Moskvitin, N. I., et al.

Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1
by: Nengyin Sheng, et al.
Published: (2015-12-01)