Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic rats
Today diabetes is one of the most common diseases in the world that affects half of the world population. The use of medicinal herbs especially green tea and cinnamon has been taken into consideration for relieving the symptoms of diabetes, but there were some different ideas about their effectivene...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2015-06-01
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| Series: | Pharmaceutical and Biomedical Research |
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| Online Access: | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-26-12&slc_lang=en&sid=1 |
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| author | Ghasem Shokri Hamed Fathi Majid Jafari Sabet Nafiseh Nasri Nasrabadi Ramin Ataee |
| author_facet | Ghasem Shokri Hamed Fathi Majid Jafari Sabet Nafiseh Nasri Nasrabadi Ramin Ataee |
| author_sort | Ghasem Shokri |
| collection | DOAJ |
| description | Today diabetes is one of the most common diseases in the world that affects half of the world population. The use of medicinal herbs especially green tea and cinnamon has been taken into consideration for relieving the symptoms of diabetes, but there were some different ideas about their effectiveness. So, this study was conducted to evaluate the effect of cinnamon and green tea extract, individually and in combination, on blood glucose and weight loss in diabetic mice with Streptozotocin (STZ). The experiment was performed on 50 Wistar rats. A total of 50 rats were divided into 10 groups of 5 and STZ was injected at the dose of 40 mg/kg/day for 5 days intraperitoneally. After diabetes induction, three groups received, 50, 100 and 200 mg doses of green tea extract, three groups received 50, 100 and 200 mg doses of cinnamon extract and three final groups received 50, 100 and 200 mg doses of cinnamon and green tea in combination by gavages daily for 6 weeks. After each period of treatments, blood glucose and the weight of animals were determined. At the end of the sixth week, blood glucose and weight loss were improved in diabetic rats in a dose-dependent manner and the dose of 200 mg/kg extract cinnamon with green tea had the most appropriate synergic effect. |
| first_indexed | 2024-12-13T00:19:31Z |
| format | Article |
| id | doaj.art-cbaf714b9d8548318633b51bee657c4f |
| institution | Directory Open Access Journal |
| issn | 2423-4486 2423-4494 |
| language | English |
| last_indexed | 2024-12-13T00:19:31Z |
| publishDate | 2015-06-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Pharmaceutical and Biomedical Research |
| spelling | doaj.art-cbaf714b9d8548318633b51bee657c4f2022-12-22T00:05:39ZengMazandaran University of Medical SciencesPharmaceutical and Biomedical Research2423-44862423-44942015-06-01122029Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic ratsGhasem Shokri0Hamed Fathi1Majid Jafari Sabet2Nafiseh Nasri Nasrabadi3Ramin Ataee4 Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran Department of Biology, Payame Noor University, Tehran,Iran Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran Today diabetes is one of the most common diseases in the world that affects half of the world population. The use of medicinal herbs especially green tea and cinnamon has been taken into consideration for relieving the symptoms of diabetes, but there were some different ideas about their effectiveness. So, this study was conducted to evaluate the effect of cinnamon and green tea extract, individually and in combination, on blood glucose and weight loss in diabetic mice with Streptozotocin (STZ). The experiment was performed on 50 Wistar rats. A total of 50 rats were divided into 10 groups of 5 and STZ was injected at the dose of 40 mg/kg/day for 5 days intraperitoneally. After diabetes induction, three groups received, 50, 100 and 200 mg doses of green tea extract, three groups received 50, 100 and 200 mg doses of cinnamon extract and three final groups received 50, 100 and 200 mg doses of cinnamon and green tea in combination by gavages daily for 6 weeks. After each period of treatments, blood glucose and the weight of animals were determined. At the end of the sixth week, blood glucose and weight loss were improved in diabetic rats in a dose-dependent manner and the dose of 200 mg/kg extract cinnamon with green tea had the most appropriate synergic effect.http://pbr.mazums.ac.ir/browse.php?a_code=A-10-26-12&slc_lang=en&sid=1Cinnamon green tea diabetes streptozotocin |
| spellingShingle | Ghasem Shokri Hamed Fathi Majid Jafari Sabet Nafiseh Nasri Nasrabadi Ramin Ataee Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic rats Pharmaceutical and Biomedical Research Cinnamon green tea diabetes streptozotocin |
| title | Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic rats |
| title_full | Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic rats |
| title_fullStr | Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic rats |
| title_full_unstemmed | Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic rats |
| title_short | Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic rats |
| title_sort | evaluation of anti diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin induced diabetic rats |
| topic | Cinnamon green tea diabetes streptozotocin |
| url | http://pbr.mazums.ac.ir/browse.php?a_code=A-10-26-12&slc_lang=en&sid=1 |
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