Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma
Summary: Microenvironment cells (MCs) play a critical role in tumor proliferation, progression, and metastasis. However, it has not been adequately addressed whether MCs could be used as a reliable prognostic marker in glioblastoma (GBM). In the current study, the cell pair (CP) score was constructe...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222011907 |
| _version_ | 1798004393217359872 |
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| author | Hao Zhang Nan Zhang Wantao Wu Zeyu Wang Ziyu Dai Xisong Liang Liyang Zhang Yun Peng Peng Luo Jian Zhang Zaoqu Liu Quan Cheng Zhixiong Liu |
| author_facet | Hao Zhang Nan Zhang Wantao Wu Zeyu Wang Ziyu Dai Xisong Liang Liyang Zhang Yun Peng Peng Luo Jian Zhang Zaoqu Liu Quan Cheng Zhixiong Liu |
| author_sort | Hao Zhang |
| collection | DOAJ |
| description | Summary: Microenvironment cells (MCs) play a critical role in tumor proliferation, progression, and metastasis. However, it has not been adequately addressed whether MCs could be used as a reliable prognostic marker in glioblastoma (GBM). In the current study, the cell pair (CP) score was constructed in 1137 GBM samples based on the cell pair algorithm and Gaussian finite mixture model (GMM) and was verified in 73 GBM samples from the Xiangya cohort. CP score predicted GBM patients’ survival and response to anti-PD-1 treatment with high sensitivity. Macrophage markers CD68 and CD163 were co-expressed with pericyte markers MCAM and MG2. Pericyte could mediate the infiltration, migration, and M2 type polarization of macrophages by MCAM. The CP score was a valuable tool for predicting survival outcomes and guiding immunotherapy for GBM patients. Cell pair pericyte/macrophage and gene pair CD163/MCAM were biologically significant in the tumor microenvironment of GBM. |
| first_indexed | 2024-04-11T12:24:07Z |
| format | Article |
| id | doaj.art-cbafe2412fc04cc796919252093bdd98 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-11T12:24:07Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-cbafe2412fc04cc796919252093bdd982022-12-22T04:24:02ZengElsevieriScience2589-00422022-09-01259104918Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastomaHao Zhang0Nan Zhang1Wantao Wu2Zeyu Wang3Ziyu Dai4Xisong Liang5Liyang Zhang6Yun Peng7Peng Luo8Jian Zhang9Zaoqu Liu10Quan Cheng11Zhixiong Liu12Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China; Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Oncology, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Geriatrics, Xiangya Hospital, Central South University, Changsha, China; Teaching and Research Section of Clinical Nursing, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China; Corresponding authorDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China; Corresponding authorSummary: Microenvironment cells (MCs) play a critical role in tumor proliferation, progression, and metastasis. However, it has not been adequately addressed whether MCs could be used as a reliable prognostic marker in glioblastoma (GBM). In the current study, the cell pair (CP) score was constructed in 1137 GBM samples based on the cell pair algorithm and Gaussian finite mixture model (GMM) and was verified in 73 GBM samples from the Xiangya cohort. CP score predicted GBM patients’ survival and response to anti-PD-1 treatment with high sensitivity. Macrophage markers CD68 and CD163 were co-expressed with pericyte markers MCAM and MG2. Pericyte could mediate the infiltration, migration, and M2 type polarization of macrophages by MCAM. The CP score was a valuable tool for predicting survival outcomes and guiding immunotherapy for GBM patients. Cell pair pericyte/macrophage and gene pair CD163/MCAM were biologically significant in the tumor microenvironment of GBM.http://www.sciencedirect.com/science/article/pii/S2589004222011907ImmunologyBiocomputational methodGenomic analysisCancer |
| spellingShingle | Hao Zhang Nan Zhang Wantao Wu Zeyu Wang Ziyu Dai Xisong Liang Liyang Zhang Yun Peng Peng Luo Jian Zhang Zaoqu Liu Quan Cheng Zhixiong Liu Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma iScience Immunology Biocomputational method Genomic analysis Cancer |
| title | Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma |
| title_full | Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma |
| title_fullStr | Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma |
| title_full_unstemmed | Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma |
| title_short | Pericyte mediates the infiltration, migration, and polarization of macrophages by CD163/MCAM axis in glioblastoma |
| title_sort | pericyte mediates the infiltration migration and polarization of macrophages by cd163 mcam axis in glioblastoma |
| topic | Immunology Biocomputational method Genomic analysis Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222011907 |
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