Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice

Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice

Abstract Background Trovafloxacin is a broad-spectrum antibiotic, recently identified as an inhibitor of pannexin-1 (Panx1) channels. Panx1 channels are important conduits for the adenosine triphosphate (ATP) release from live and dying cells that enhances the inflammatory response of immune cells....

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Bibliographic Details
Main Authors: Charu Garg, Joon Ho Seo, Jayalakshmi Ramachandran, Ji Meng Loh, Frances Calderon, Jorge E. Contreras
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Neuroinflammation
Subjects:
Brain injury
Neuroinflammation
Microglia
Pannexin
Hemichannel
Online Access:http://link.springer.com/article/10.1186/s12974-018-1069-9

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