Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-κB signaling and depleting Bcr-Abl

Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-κB signaling and depleting Bcr-Abl

<p>Abstract</p> <p>Background</p> <p>Chronic myelogenous leukemia (CML) is characterized by the chimeric tyrosine kinase Bcr-Abl. Bcr-Abl-T315I is the notorious point mutation that causes resistance to imatinib and the second generation tyrosine kinase inhibitors, leadi...

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Bibliographic Details
Main Authors: Cao Qi, Li Juan, Chen Chun, Jin Yanli, Lu Zhongzheng, Pan Jingxuan
Format: Article
Language:English
Published: BMC 2010-05-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/112

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