Evaluation of Tranexemic Acid Effect on Blood Loss and Transfusion in Femoral Shaft Surgery
Background: In major operations, like femoral bone surgery due to extension of surgical field, we may have severe bleeding and massive transfusion. In this study, we aimed to evaluate the effect of tranexemic acid on reduction of bleeding and transfusion in femoral shaft surgery.. Methods: After ob...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2012-08-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/1688 |
| _version_ | 1797711132938469376 |
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| author | Parviz Kashefi Sayed Morteza Heidari Hamid Saryazdi Mohammad Javdan |
| author_facet | Parviz Kashefi Sayed Morteza Heidari Hamid Saryazdi Mohammad Javdan |
| author_sort | Parviz Kashefi |
| collection | DOAJ |
| description | Background: In major operations, like femoral bone surgery due to extension of surgical field, we may have severe bleeding and massive transfusion. In this study, we aimed to evaluate the effect of tranexemic acid on reduction of bleeding and transfusion in femoral shaft surgery..
Methods: After obtaining consent, 80 candidates of femoral shaft surgery aged 18-64 years, in score 1 and 2 of The American Society of Anesthesiologists scale (ASA) were entered a double blind prospective clinical trial. Patients randomly divided into 2 groups of receiving 15 mg/kg tranexemic acid in 5 ml solution and receiving 5 ml normal salin as placebo. All patients received standard monitoring and spinal anesthesia was done by injecting bupivacaine. The amount of bleeding was measured and recorded.
Findings: There was no significant difference between the two groups in age and sex. Mean blood loss and transfusion requirement in tranexemic acid group was significantly less than the placebo group (P < 0.05). There was no significant difference between the two groups in nausea, vomiting and vertigo.
Conclusion: Our results indicated that 15 mg/kg intravenous tranexemic acid (one hour before the operation) was significantly effective in decreasing blood loss and transfusion requirement.
Keywords: Tranexemicacid, Blood loss, Transfusion. |
| first_indexed | 2024-03-12T07:02:34Z |
| format | Article |
| id | doaj.art-cbb621b00e1249859948bb1855671047 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T07:02:34Z |
| publishDate | 2012-08-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-cbb621b00e1249859948bb18556710472023-09-02T23:39:24ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2012-08-01301921084Evaluation of Tranexemic Acid Effect on Blood Loss and Transfusion in Femoral Shaft SurgeryParviz Kashefi0Sayed Morteza Heidari1Hamid Saryazdi2Mohammad Javdan3Associate Professor, Department of Anesthesiology and Intensive Care Unit, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Anesthesiology and Intensive Care Unit, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Anesthesiology and Intensive Care Unit, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Orthopedic, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: In major operations, like femoral bone surgery due to extension of surgical field, we may have severe bleeding and massive transfusion. In this study, we aimed to evaluate the effect of tranexemic acid on reduction of bleeding and transfusion in femoral shaft surgery.. Methods: After obtaining consent, 80 candidates of femoral shaft surgery aged 18-64 years, in score 1 and 2 of The American Society of Anesthesiologists scale (ASA) were entered a double blind prospective clinical trial. Patients randomly divided into 2 groups of receiving 15 mg/kg tranexemic acid in 5 ml solution and receiving 5 ml normal salin as placebo. All patients received standard monitoring and spinal anesthesia was done by injecting bupivacaine. The amount of bleeding was measured and recorded. Findings: There was no significant difference between the two groups in age and sex. Mean blood loss and transfusion requirement in tranexemic acid group was significantly less than the placebo group (P < 0.05). There was no significant difference between the two groups in nausea, vomiting and vertigo. Conclusion: Our results indicated that 15 mg/kg intravenous tranexemic acid (one hour before the operation) was significantly effective in decreasing blood loss and transfusion requirement. Keywords: Tranexemicacid, Blood loss, Transfusion.http://jims.mui.ac.ir/index.php/jims/article/view/1688 |
| spellingShingle | Parviz Kashefi Sayed Morteza Heidari Hamid Saryazdi Mohammad Javdan Evaluation of Tranexemic Acid Effect on Blood Loss and Transfusion in Femoral Shaft Surgery مجله دانشکده پزشکی اصفهان |
| title | Evaluation of Tranexemic Acid Effect on Blood Loss and Transfusion in Femoral Shaft Surgery |
| title_full | Evaluation of Tranexemic Acid Effect on Blood Loss and Transfusion in Femoral Shaft Surgery |
| title_fullStr | Evaluation of Tranexemic Acid Effect on Blood Loss and Transfusion in Femoral Shaft Surgery |
| title_full_unstemmed | Evaluation of Tranexemic Acid Effect on Blood Loss and Transfusion in Femoral Shaft Surgery |
| title_short | Evaluation of Tranexemic Acid Effect on Blood Loss and Transfusion in Femoral Shaft Surgery |
| title_sort | evaluation of tranexemic acid effect on blood loss and transfusion in femoral shaft surgery |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/1688 |
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