Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology
Abstract tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in cellular differentiation, proliferation, and apopto...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-10-01
|
| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01341-8 |
| _version_ | 1827770470769885184 |
|---|---|
| author | Juan Du Tianyi Huang Zhen Zheng Shuai Fang Hongxia Deng Kaitai Liu |
| author_facet | Juan Du Tianyi Huang Zhen Zheng Shuai Fang Hongxia Deng Kaitai Liu |
| author_sort | Juan Du |
| collection | DOAJ |
| description | Abstract tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in cellular differentiation, proliferation, and apoptosis. tsRNA-related abnormalities have a significant influence on the onset, development, and progression of numerous human diseases, including malignant tumors through affecting the cell cycle and specific signaling molecules. This review introduced origins together with tsRNAs classification, providing a summary for regulatory mechanism and physiological function while dysfunctional effect of tsRNAs in digestive system diseases, focusing on the clinical prospects of tsRNAs for diagnostic and prognostic biomarkers. Video Abstract |
| first_indexed | 2024-03-11T12:40:00Z |
| format | Article |
| id | doaj.art-cbbaea7b5be244fd87121ef4c1dc7ace |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-11T12:40:00Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-cbbaea7b5be244fd87121ef4c1dc7ace2023-11-05T12:25:00ZengBMCCell Communication and Signaling1478-811X2023-10-0121111710.1186/s12964-023-01341-8Biological function and clinical application prospect of tsRNAs in digestive system biology and pathologyJuan Du0Tianyi Huang1Zhen Zheng2Shuai Fang3Hongxia Deng4Kaitai Liu5Health Science Center, Ningbo UniversityHealth Science Center, Ningbo UniversityDepartment of Radiation Oncology, The Affiliated Lihuili Hospital of Ningbo UniversityThe Affiliated Hospital of Medical School of Ningbo UniversityThe Affiliated Lihuili Hospital of Ningbo UniversityDepartment of Radiation Oncology, The Affiliated Lihuili Hospital of Ningbo UniversityAbstract tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing, ribosome biogenesis, retrotransposition, and epigenetic inheritance, as well as involvement in cellular differentiation, proliferation, and apoptosis. tsRNA-related abnormalities have a significant influence on the onset, development, and progression of numerous human diseases, including malignant tumors through affecting the cell cycle and specific signaling molecules. This review introduced origins together with tsRNAs classification, providing a summary for regulatory mechanism and physiological function while dysfunctional effect of tsRNAs in digestive system diseases, focusing on the clinical prospects of tsRNAs for diagnostic and prognostic biomarkers. Video Abstracthttps://doi.org/10.1186/s12964-023-01341-8tsRNAsDigestive diseaseDiagnosisPrognosisBiomarkers |
| spellingShingle | Juan Du Tianyi Huang Zhen Zheng Shuai Fang Hongxia Deng Kaitai Liu Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology Cell Communication and Signaling tsRNAs Digestive disease Diagnosis Prognosis Biomarkers |
| title | Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology |
| title_full | Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology |
| title_fullStr | Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology |
| title_full_unstemmed | Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology |
| title_short | Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology |
| title_sort | biological function and clinical application prospect of tsrnas in digestive system biology and pathology |
| topic | tsRNAs Digestive disease Diagnosis Prognosis Biomarkers |
| url | https://doi.org/10.1186/s12964-023-01341-8 |
| work_keys_str_mv | AT juandu biologicalfunctionandclinicalapplicationprospectoftsrnasindigestivesystembiologyandpathology AT tianyihuang biologicalfunctionandclinicalapplicationprospectoftsrnasindigestivesystembiologyandpathology AT zhenzheng biologicalfunctionandclinicalapplicationprospectoftsrnasindigestivesystembiologyandpathology AT shuaifang biologicalfunctionandclinicalapplicationprospectoftsrnasindigestivesystembiologyandpathology AT hongxiadeng biologicalfunctionandclinicalapplicationprospectoftsrnasindigestivesystembiologyandpathology AT kaitailiu biologicalfunctionandclinicalapplicationprospectoftsrnasindigestivesystembiologyandpathology |