Impact of bone marrow nucleated cell subfractions on transplant outcomes in patients with acute lymphoblastic leukemia
Objectives Our previous study showed that a high pre-transplant nucleated cell count in the bone marrow is associated with increased non-relapse mortality (NRM) and decreased overall survival (OS) in patients with acute lymphoblastic leukemia (ALL) in remission. In this retrospective multicenter stu...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2024.2424053 |
| _version_ | 1826936801298743296 |
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| author | Jun Nukui Takayoshi Tachibana Takuya Miyazaki Masatsugu Tanaka Kenji Matsumoto Yoshimi Ishii Ayumi Numata Yuki Nakajima Ayako Matsumura Taisei Suzuki Akihiko Izumi Natsuki Hirose Koji Yamamoto Maki Hagihara Shin Fujisawa Hideaki Nakajima |
| author_facet | Jun Nukui Takayoshi Tachibana Takuya Miyazaki Masatsugu Tanaka Kenji Matsumoto Yoshimi Ishii Ayumi Numata Yuki Nakajima Ayako Matsumura Taisei Suzuki Akihiko Izumi Natsuki Hirose Koji Yamamoto Maki Hagihara Shin Fujisawa Hideaki Nakajima |
| author_sort | Jun Nukui |
| collection | DOAJ |
| description | Objectives Our previous study showed that a high pre-transplant nucleated cell count in the bone marrow is associated with increased non-relapse mortality (NRM) and decreased overall survival (OS) in patients with acute lymphoblastic leukemia (ALL) in remission. In this retrospective multicenter study, we aimed to examine the association between nucleated cell subfractions and transplant outcomes using the same patient cohort as our previous study.Methods This study included patients with ALL who underwent their first allogeneic hematopoietic stem cell transplantation (allo-HSCT) between 2010 and 2022. The patients were stratified into high and low cell group levels to compare transplant outcomes using cutoff values for predicting OS in each subfraction determined using receiver operating curves.Results In the cohort of 134 patients, the median values for myeloid, erythroid, monocyte, and lymphocyte series were 16,860/µL (468–229,296), 15,584/µL (34–246,992), 1,446/µL (70–25,296), and 4,215/µL (90–33,856), respectively.Discussion The univariate analysis showed that the groups with high levels of myeloid cells (≥38,000/µL, n = 48), erythroid cells (≥25,000/µL, n = 45), and monocyte cells (≥4,200/µL, n = 44) were all associated with worse 3-year OS and higher NRM than the low-level groups. These findings were confirmed by using multivariate analysis. The high cell count group showed a higher incidence of NRM associated with acute graft-versus-host disease or immunological disorders.Conclusion High myeloid, erythroid, and monocytic cell levels in the bone marrow before allo-HSCT may independently increase the risk of NRM and reduce OS. |
| first_indexed | 2025-02-17T18:28:05Z |
| format | Article |
| id | doaj.art-cbbd33aabd284c38a0e4d611c81d16c1 |
| institution | Directory Open Access Journal |
| issn | 1607-8454 |
| language | English |
| last_indexed | 2025-02-17T18:28:05Z |
| publishDate | 2024-12-01 |
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| series | Hematology |
| spelling | doaj.art-cbbd33aabd284c38a0e4d611c81d16c12024-12-12T15:08:54ZengTaylor & Francis GroupHematology1607-84542024-12-0129110.1080/16078454.2024.2424053Impact of bone marrow nucleated cell subfractions on transplant outcomes in patients with acute lymphoblastic leukemiaJun Nukui0Takayoshi Tachibana1Takuya Miyazaki2Masatsugu Tanaka3Kenji Matsumoto4Yoshimi Ishii5Ayumi Numata6Yuki Nakajima7Ayako Matsumura8Taisei Suzuki9Akihiko Izumi10Natsuki Hirose11Koji Yamamoto12Maki Hagihara13Shin Fujisawa14Hideaki Nakajima15Department of Hematology, Kanagawa Cancer Center, Yokohama, JapanDepartment of Hematology, Kanagawa Cancer Center, Yokohama, JapanDepartment of Hematology, Kanagawa Cancer Center, Yokohama, JapanDepartment of Hematology, Kanagawa Cancer Center, Yokohama, JapanDepartment of Hematology, Kanagawa Cancer Center, Yokohama, JapanDepartment of Hematology, Yokohama City University Medical Center, Yokohama, JapanDepartment of Hematology, Kanagawa Cancer Center, Yokohama, JapanDepartment of Hematology, Yokohama City University Medical Center, Yokohama, JapanDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Hematology, Kanagawa Cancer Center, Yokohama, JapanDepartment of Hematology, Kanagawa Cancer Center, Yokohama, JapanDepartment of Hematology, Kanagawa Cancer Center, Yokohama, JapanDepartment of Biostatistics, Yokohama City University School of Medicine, Yokohama, JapanDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Hematology, Yokohama City University Medical Center, Yokohama, JapanDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, JapanObjectives Our previous study showed that a high pre-transplant nucleated cell count in the bone marrow is associated with increased non-relapse mortality (NRM) and decreased overall survival (OS) in patients with acute lymphoblastic leukemia (ALL) in remission. In this retrospective multicenter study, we aimed to examine the association between nucleated cell subfractions and transplant outcomes using the same patient cohort as our previous study.Methods This study included patients with ALL who underwent their first allogeneic hematopoietic stem cell transplantation (allo-HSCT) between 2010 and 2022. The patients were stratified into high and low cell group levels to compare transplant outcomes using cutoff values for predicting OS in each subfraction determined using receiver operating curves.Results In the cohort of 134 patients, the median values for myeloid, erythroid, monocyte, and lymphocyte series were 16,860/µL (468–229,296), 15,584/µL (34–246,992), 1,446/µL (70–25,296), and 4,215/µL (90–33,856), respectively.Discussion The univariate analysis showed that the groups with high levels of myeloid cells (≥38,000/µL, n = 48), erythroid cells (≥25,000/µL, n = 45), and monocyte cells (≥4,200/µL, n = 44) were all associated with worse 3-year OS and higher NRM than the low-level groups. These findings were confirmed by using multivariate analysis. The high cell count group showed a higher incidence of NRM associated with acute graft-versus-host disease or immunological disorders.Conclusion High myeloid, erythroid, and monocytic cell levels in the bone marrow before allo-HSCT may independently increase the risk of NRM and reduce OS.https://www.tandfonline.com/doi/10.1080/16078454.2024.2424053Nucleated cell countacute lymphoblastic leukemiaallogeneic hematopoietic stem cell transplantationoverall survivalnon-relapse mortalitybone marrow nucleated cell count |
| spellingShingle | Jun Nukui Takayoshi Tachibana Takuya Miyazaki Masatsugu Tanaka Kenji Matsumoto Yoshimi Ishii Ayumi Numata Yuki Nakajima Ayako Matsumura Taisei Suzuki Akihiko Izumi Natsuki Hirose Koji Yamamoto Maki Hagihara Shin Fujisawa Hideaki Nakajima Impact of bone marrow nucleated cell subfractions on transplant outcomes in patients with acute lymphoblastic leukemia Hematology Nucleated cell count acute lymphoblastic leukemia allogeneic hematopoietic stem cell transplantation overall survival non-relapse mortality bone marrow nucleated cell count |
| title | Impact of bone marrow nucleated cell subfractions on transplant outcomes in patients with acute lymphoblastic leukemia |
| title_full | Impact of bone marrow nucleated cell subfractions on transplant outcomes in patients with acute lymphoblastic leukemia |
| title_fullStr | Impact of bone marrow nucleated cell subfractions on transplant outcomes in patients with acute lymphoblastic leukemia |
| title_full_unstemmed | Impact of bone marrow nucleated cell subfractions on transplant outcomes in patients with acute lymphoblastic leukemia |
| title_short | Impact of bone marrow nucleated cell subfractions on transplant outcomes in patients with acute lymphoblastic leukemia |
| title_sort | impact of bone marrow nucleated cell subfractions on transplant outcomes in patients with acute lymphoblastic leukemia |
| topic | Nucleated cell count acute lymphoblastic leukemia allogeneic hematopoietic stem cell transplantation overall survival non-relapse mortality bone marrow nucleated cell count |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2024.2424053 |
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