Renin-Angiotensin-Aldosterone System in Women Using Combined Oral Contraceptive: A Systematic Review
Abstract Objective To describe the effects of combined oral contraceptives (COC) on the renin-angiotensin-aldosterone system (RAAS). Data sourcesThis is a systematic review according to the criteria of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), registered in PROSPE...
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| Format: | Article |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2022-08-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000700710&tlng=en |
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| author | Priscilla Araújo dos Santos Alice Miranda de Oliveira Caroline Queiroz Alves Clóvis Figueiredo Souza Filho Ana Marice Teixeira Ladeia Jefferson Petto |
| author_facet | Priscilla Araújo dos Santos Alice Miranda de Oliveira Caroline Queiroz Alves Clóvis Figueiredo Souza Filho Ana Marice Teixeira Ladeia Jefferson Petto |
| author_sort | Priscilla Araújo dos Santos |
| collection | DOAJ |
| description | Abstract Objective To describe the effects of combined oral contraceptives (COC) on the renin-angiotensin-aldosterone system (RAAS). Data sourcesThis is a systematic review according to the criteria of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), registered in PROSPERO under the ID: CRD42020200019. Searches were performed between August 2020 and December 2021, in the following databases: Medline via Pubmed, Cochrane Central Library, Scientific Electronic Library Online, and Latin American and Caribbean Literature in Health Sciences via Virtual Health Library. The effects of the combined oral contraceptive on plasma renin activity values, plasma renin values, angiotensinogen values— also known as plasma renin substrate— angiotensin, and/or aldosterone values. Study selectionA total of 877 studies were selected and, of these, 10 articles met the eligibility criteria and were included in this review. Data collectionData were combined through qualitative synthesis and included in a spreadsheet previously prepared by the authors. Data synthesisThe collected samples ranged from 18 to 137 participants, totaling 501 women aged between 18 and 49 years throughout all studies. The studies showed increased activity of plasma renin, plasma renin substrate, angiotensin II, and aldosterone in this population. Conclusion The findings of this study suggest that the COC promotes greater activation of the RAAS. Supporting the idea that its use is related to an increased risk of cardiovascular events, including systemic arterial hypertension. |
| first_indexed | 2024-04-13T02:45:20Z |
| format | Article |
| id | doaj.art-cbbebe09ac8b4e93a4feb733ef1d624e |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-04-13T02:45:20Z |
| publishDate | 2022-08-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-cbbebe09ac8b4e93a4feb733ef1d624e2022-12-22T03:06:04ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032022-08-0144771071810.1055/s-0042-1745790Renin-Angiotensin-Aldosterone System in Women Using Combined Oral Contraceptive: A Systematic ReviewPriscilla Araújo dos Santoshttps://orcid.org/0000-0002-2518-2168Alice Miranda de Oliveirahttps://orcid.org/0000-0002-3154-0953Caroline Queiroz Alveshttps://orcid.org/0000-0001-7318-1111Clóvis Figueiredo Souza Filhohttps://orcid.org/0000-0001-6606-0127Ana Marice Teixeira Ladeiahttps://orcid.org/0000-0002-2235-7401Jefferson Pettohttps://orcid.org/0000-0002-5748-2675Abstract Objective To describe the effects of combined oral contraceptives (COC) on the renin-angiotensin-aldosterone system (RAAS). Data sourcesThis is a systematic review according to the criteria of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), registered in PROSPERO under the ID: CRD42020200019. Searches were performed between August 2020 and December 2021, in the following databases: Medline via Pubmed, Cochrane Central Library, Scientific Electronic Library Online, and Latin American and Caribbean Literature in Health Sciences via Virtual Health Library. The effects of the combined oral contraceptive on plasma renin activity values, plasma renin values, angiotensinogen values— also known as plasma renin substrate— angiotensin, and/or aldosterone values. Study selectionA total of 877 studies were selected and, of these, 10 articles met the eligibility criteria and were included in this review. Data collectionData were combined through qualitative synthesis and included in a spreadsheet previously prepared by the authors. Data synthesisThe collected samples ranged from 18 to 137 participants, totaling 501 women aged between 18 and 49 years throughout all studies. The studies showed increased activity of plasma renin, plasma renin substrate, angiotensin II, and aldosterone in this population. Conclusion The findings of this study suggest that the COC promotes greater activation of the RAAS. Supporting the idea that its use is related to an increased risk of cardiovascular events, including systemic arterial hypertension.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000700710&tlng=encontraceptivesblood pressurerenin-angiotensin systemhypertensionwomen's health |
| spellingShingle | Priscilla Araújo dos Santos Alice Miranda de Oliveira Caroline Queiroz Alves Clóvis Figueiredo Souza Filho Ana Marice Teixeira Ladeia Jefferson Petto Renin-Angiotensin-Aldosterone System in Women Using Combined Oral Contraceptive: A Systematic Review Revista Brasileira de Ginecologia e Obstetrícia contraceptives blood pressure renin-angiotensin system hypertension women's health |
| title | Renin-Angiotensin-Aldosterone System in Women Using Combined Oral Contraceptive: A Systematic Review |
| title_full | Renin-Angiotensin-Aldosterone System in Women Using Combined Oral Contraceptive: A Systematic Review |
| title_fullStr | Renin-Angiotensin-Aldosterone System in Women Using Combined Oral Contraceptive: A Systematic Review |
| title_full_unstemmed | Renin-Angiotensin-Aldosterone System in Women Using Combined Oral Contraceptive: A Systematic Review |
| title_short | Renin-Angiotensin-Aldosterone System in Women Using Combined Oral Contraceptive: A Systematic Review |
| title_sort | renin angiotensin aldosterone system in women using combined oral contraceptive a systematic review |
| topic | contraceptives blood pressure renin-angiotensin system hypertension women's health |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032022000700710&tlng=en |
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