Prognosis and survival study in patients with gastric adenocarcinoma and its relationship with pRb expression alteration: A retrospective IHC‐based study
Abstract Background and Objective Among cancers, gastric cancer has the fifth highest incidence worldwide and is the third most common mortality factor, which may have been due to inadequate knowledge of its molecular pathogenesis. The retinoblastoma gene (RB1), a tumor suppressor gene, may have a r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1445 |
| _version_ | 1797770701872037888 |
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| author | Shokouh Taghipour Zahir Seyyed Hossein Razavi Farzan SafiDahaj Koorosh Rahmani Sajad Sadeghinejad‐Alamabadi |
| author_facet | Shokouh Taghipour Zahir Seyyed Hossein Razavi Farzan SafiDahaj Koorosh Rahmani Sajad Sadeghinejad‐Alamabadi |
| author_sort | Shokouh Taghipour Zahir |
| collection | DOAJ |
| description | Abstract Background and Objective Among cancers, gastric cancer has the fifth highest incidence worldwide and is the third most common mortality factor, which may have been due to inadequate knowledge of its molecular pathogenesis. The retinoblastoma gene (RB1), a tumor suppressor gene, may have a role in gastric cancer. This research aims to assess Rb expression as a prognostic marker to obtain more insight regarding gastric cancer. Methods This retrospective analytical study was done on 61 patients (45 males and 16 females) with gastric adenocarcinoma admitted from 2010 to 2012 in Shahid Sadoughi and Mortaz hospitals, Yazd, Iran. Demographic data, including age, gender, clinical signs and symptoms, and pathology reports, were retrieved from patients' hospital folders. Then, the altered Retinoblastoma gene expression was evaluated by immunohistochemistry studies. Acquired data were analyzed by SPSS software v.16. p < 0.05 was statistically considered meaningful. Results In this study, the ratio of men to women was higher (2.81:1), and the mean age of patients was 62.44 years. About 90.2% of patients died during the study. There was no meaningful relationship between the presence of pRb, the intensity of staining, the percentage of staining with patients' age, gender, tumor grading, and survival rate (p > 0.05). There was only a meaningful relationship between the grade of tumors and survival rate (p = 0.039). Conclusion Altered pRB expression is not common in gastric cancer and does not impact the survival and grading of tumors. Poorly differentiated tumors had an ominous outcome with the lowest survival time. |
| first_indexed | 2024-03-12T21:26:02Z |
| format | Article |
| id | doaj.art-cbbf265d12d4427686ae84a1dc6d7f9a |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-12T21:26:02Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-cbbf265d12d4427686ae84a1dc6d7f9a2023-07-28T08:52:32ZengWileyHealth Science Reports2398-88352023-07-0167n/an/a10.1002/hsr2.1445Prognosis and survival study in patients with gastric adenocarcinoma and its relationship with pRb expression alteration: A retrospective IHC‐based studyShokouh Taghipour Zahir0Seyyed Hossein Razavi1Farzan SafiDahaj2Koorosh Rahmani3Sajad Sadeghinejad‐Alamabadi4Clinical and Surgical Pathology Shahid Sadoughi University of Medical Sciences Yazd IranClinical and Surgical Pathology Shahid Sadoughi University of Medical Sciences Yazd IranClinical and Surgical Pathology Shahid Sadoughi University of Medical Sciences Yazd IranClinical and Surgical Pathology Shahid Sadoughi University of Medical Sciences Yazd IranClinical and Surgical Pathology Shahid Sadoughi University of Medical Sciences Yazd IranAbstract Background and Objective Among cancers, gastric cancer has the fifth highest incidence worldwide and is the third most common mortality factor, which may have been due to inadequate knowledge of its molecular pathogenesis. The retinoblastoma gene (RB1), a tumor suppressor gene, may have a role in gastric cancer. This research aims to assess Rb expression as a prognostic marker to obtain more insight regarding gastric cancer. Methods This retrospective analytical study was done on 61 patients (45 males and 16 females) with gastric adenocarcinoma admitted from 2010 to 2012 in Shahid Sadoughi and Mortaz hospitals, Yazd, Iran. Demographic data, including age, gender, clinical signs and symptoms, and pathology reports, were retrieved from patients' hospital folders. Then, the altered Retinoblastoma gene expression was evaluated by immunohistochemistry studies. Acquired data were analyzed by SPSS software v.16. p < 0.05 was statistically considered meaningful. Results In this study, the ratio of men to women was higher (2.81:1), and the mean age of patients was 62.44 years. About 90.2% of patients died during the study. There was no meaningful relationship between the presence of pRb, the intensity of staining, the percentage of staining with patients' age, gender, tumor grading, and survival rate (p > 0.05). There was only a meaningful relationship between the grade of tumors and survival rate (p = 0.039). Conclusion Altered pRB expression is not common in gastric cancer and does not impact the survival and grading of tumors. Poorly differentiated tumors had an ominous outcome with the lowest survival time.https://doi.org/10.1002/hsr2.1445neoplasm gradingprognosisRb genestomach neoplasmssurvival time |
| spellingShingle | Shokouh Taghipour Zahir Seyyed Hossein Razavi Farzan SafiDahaj Koorosh Rahmani Sajad Sadeghinejad‐Alamabadi Prognosis and survival study in patients with gastric adenocarcinoma and its relationship with pRb expression alteration: A retrospective IHC‐based study Health Science Reports neoplasm grading prognosis Rb gene stomach neoplasms survival time |
| title | Prognosis and survival study in patients with gastric adenocarcinoma and its relationship with pRb expression alteration: A retrospective IHC‐based study |
| title_full | Prognosis and survival study in patients with gastric adenocarcinoma and its relationship with pRb expression alteration: A retrospective IHC‐based study |
| title_fullStr | Prognosis and survival study in patients with gastric adenocarcinoma and its relationship with pRb expression alteration: A retrospective IHC‐based study |
| title_full_unstemmed | Prognosis and survival study in patients with gastric adenocarcinoma and its relationship with pRb expression alteration: A retrospective IHC‐based study |
| title_short | Prognosis and survival study in patients with gastric adenocarcinoma and its relationship with pRb expression alteration: A retrospective IHC‐based study |
| title_sort | prognosis and survival study in patients with gastric adenocarcinoma and its relationship with prb expression alteration a retrospective ihc based study |
| topic | neoplasm grading prognosis Rb gene stomach neoplasms survival time |
| url | https://doi.org/10.1002/hsr2.1445 |
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