Modeling ability to resist alcohol in the human laboratory: A pilot study
Background: Roughly half of patients with alcohol use disorder prefer non-abstinence based approaches to treatment. However, only individuals who can limit their alcohol use after low-risk consumption are most likely to benefit from these approaches. This pilot study developed a laboratory-based int...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Drug and Alcohol Dependence Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772724622000804 |
| _version_ | 1828165804917522432 |
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| author | Matthew E. Sloan Joanna R. Sells Courtney L. Vaughan James K. Morris Nancy E. Ortega Sachin Sundar Soundarya Soundararajan Bethany L. Stangl Joshua Gowin Sumedha Chawla Nancy Diazgranados Sherry A. McKee Andrew Waters Vijay A. Ramchandani |
| author_facet | Matthew E. Sloan Joanna R. Sells Courtney L. Vaughan James K. Morris Nancy E. Ortega Sachin Sundar Soundarya Soundararajan Bethany L. Stangl Joshua Gowin Sumedha Chawla Nancy Diazgranados Sherry A. McKee Andrew Waters Vijay A. Ramchandani |
| author_sort | Matthew E. Sloan |
| collection | DOAJ |
| description | Background: Roughly half of patients with alcohol use disorder prefer non-abstinence based approaches to treatment. However, only individuals who can limit their alcohol use after low-risk consumption are most likely to benefit from these approaches. This pilot study developed a laboratory-based intravenous alcohol self-administration paradigm to determine the characteristics of individuals who could successfully resist consuming alcohol after an initial exposure. Methods: Seventeen non-treatment seeking heavy drinkers completed two versions of an intravenous alcohol self-administration paradigm designed to assess impaired control over alcohol use. In the paradigm, participants received a priming dose of alcohol and then entered a 120-min resist phase, in which they received monetary rewards if they resisted self-administering alcohol. We used Cox proportional hazards regression to determine the impact of craving and Impaired Control Scale scores on rate of lapse. Results: 64.7% of participants across both versions of the paradigm were unable to resist alcohol for the duration of the session. Craving at baseline (HR = 1.07, 95% CI 1.01-1.13, p = 0.02) and following priming (HR = 1.08, 95% CI 1.02-1.15, p = 0.01) were associated with rate of lapse. Individuals who lapsed endorsed greater attempts to control their drinking over the prior six months compared to individuals who resisted. Conclusions: This study provides preliminary evidence that craving may be predictive of risk of lapse in individuals who are trying to limit alcohol intake after consuming a small initial amount of alcohol. Future studies should test this paradigm in a larger and more diverse sample. |
| first_indexed | 2024-04-12T01:50:52Z |
| format | Article |
| id | doaj.art-cbc0e5bd289a493daf6cde7635432487 |
| institution | Directory Open Access Journal |
| issn | 2772-7246 |
| language | English |
| last_indexed | 2024-04-12T01:50:52Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Drug and Alcohol Dependence Reports |
| spelling | doaj.art-cbc0e5bd289a493daf6cde76354324872022-12-22T03:52:57ZengElsevierDrug and Alcohol Dependence Reports2772-72462022-12-015100105Modeling ability to resist alcohol in the human laboratory: A pilot studyMatthew E. Sloan0Joanna R. Sells1Courtney L. Vaughan2James K. Morris3Nancy E. Ortega4Sachin Sundar5Soundarya Soundararajan6Bethany L. Stangl7Joshua Gowin8Sumedha Chawla9Nancy Diazgranados10Sherry A. McKee11Andrew Waters12Vijay A. Ramchandani13Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Division of Neurosciences and Clinical Translation, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada; Department of Psychological Clinical Science, University of Toronto Scarborough, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Corresponding author at: Addictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.Department of Medical and Clinical Psychology, Uniformed Services University of Health Science, USA; Human Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Rm 2-2352, Bethesda, MD 20892, USADepartment of Medical and Clinical Psychology, Uniformed Services University of Health Science, USA; Human Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Rm 2-2352, Bethesda, MD 20892, USAHuman Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Rm 2-2352, Bethesda, MD 20892, USAHuman Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Rm 2-2352, Bethesda, MD 20892, USAHuman Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Rm 2-2352, Bethesda, MD 20892, USAHuman Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Rm 2-2352, Bethesda, MD 20892, USAHuman Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Rm 2-2352, Bethesda, MD 20892, USAHuman Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Rm 2-2352, Bethesda, MD 20892, USA; Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USAHuman Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Rm 2-2352, Bethesda, MD 20892, USAOffice of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USAYale University, New Haven, CT, USADepartment of Medical and Clinical Psychology, Uniformed Services University of Health Science, USAHuman Psychopharmacology Laboratory, National Institute on Alcohol Abuse and Alcoholism, 10 Center Drive, Rm 2-2352, Bethesda, MD 20892, USA; Corresponding author.Background: Roughly half of patients with alcohol use disorder prefer non-abstinence based approaches to treatment. However, only individuals who can limit their alcohol use after low-risk consumption are most likely to benefit from these approaches. This pilot study developed a laboratory-based intravenous alcohol self-administration paradigm to determine the characteristics of individuals who could successfully resist consuming alcohol after an initial exposure. Methods: Seventeen non-treatment seeking heavy drinkers completed two versions of an intravenous alcohol self-administration paradigm designed to assess impaired control over alcohol use. In the paradigm, participants received a priming dose of alcohol and then entered a 120-min resist phase, in which they received monetary rewards if they resisted self-administering alcohol. We used Cox proportional hazards regression to determine the impact of craving and Impaired Control Scale scores on rate of lapse. Results: 64.7% of participants across both versions of the paradigm were unable to resist alcohol for the duration of the session. Craving at baseline (HR = 1.07, 95% CI 1.01-1.13, p = 0.02) and following priming (HR = 1.08, 95% CI 1.02-1.15, p = 0.01) were associated with rate of lapse. Individuals who lapsed endorsed greater attempts to control their drinking over the prior six months compared to individuals who resisted. Conclusions: This study provides preliminary evidence that craving may be predictive of risk of lapse in individuals who are trying to limit alcohol intake after consuming a small initial amount of alcohol. Future studies should test this paradigm in a larger and more diverse sample.http://www.sciencedirect.com/science/article/pii/S2772724622000804Alcohol self-administrationAlcoholismAlcohol abstinenceCravingImpaired control |
| spellingShingle | Matthew E. Sloan Joanna R. Sells Courtney L. Vaughan James K. Morris Nancy E. Ortega Sachin Sundar Soundarya Soundararajan Bethany L. Stangl Joshua Gowin Sumedha Chawla Nancy Diazgranados Sherry A. McKee Andrew Waters Vijay A. Ramchandani Modeling ability to resist alcohol in the human laboratory: A pilot study Drug and Alcohol Dependence Reports Alcohol self-administration Alcoholism Alcohol abstinence Craving Impaired control |
| title | Modeling ability to resist alcohol in the human laboratory: A pilot study |
| title_full | Modeling ability to resist alcohol in the human laboratory: A pilot study |
| title_fullStr | Modeling ability to resist alcohol in the human laboratory: A pilot study |
| title_full_unstemmed | Modeling ability to resist alcohol in the human laboratory: A pilot study |
| title_short | Modeling ability to resist alcohol in the human laboratory: A pilot study |
| title_sort | modeling ability to resist alcohol in the human laboratory a pilot study |
| topic | Alcohol self-administration Alcoholism Alcohol abstinence Craving Impaired control |
| url | http://www.sciencedirect.com/science/article/pii/S2772724622000804 |
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