Hyaluronic Acid in Biomedical Fields: New Trends from Chemistry to Biomaterial Applications
The aim of this review is to give an updated perspective about the methods for chemical modifications of hyaluronic acid (HA) toward the development of new applications in medical devices and material engineering. After a brief introduction on chemical, structural and biological features of this imp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/14372 |
| _version_ | 1797465055494668288 |
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| author | Antonia Di Mola Maria Rosaria Landi Antonio Massa Ugo D’Amora Vincenzo Guarino |
| author_facet | Antonia Di Mola Maria Rosaria Landi Antonio Massa Ugo D’Amora Vincenzo Guarino |
| author_sort | Antonia Di Mola |
| collection | DOAJ |
| description | The aim of this review is to give an updated perspective about the methods for chemical modifications of hyaluronic acid (HA) toward the development of new applications in medical devices and material engineering. After a brief introduction on chemical, structural and biological features of this important natural polysaccharide, the most important methods for chemical and physical modifications are disclosed, discussing both on the formation of new covalent bonds and the interaction with other natural polysaccharides. These strategies are of paramount importance in the production of new medical devices and materials with improved properties. In particular, the use of HA in the development of new materials by means of additive manufacturing techniques as electro fluid dynamics, i.e., electrospinning for micro to nanofibres, and three-dimensional bioprinting is also discussed. |
| first_indexed | 2024-03-09T18:16:01Z |
| format | Article |
| id | doaj.art-cbc348d9d00c452dbd57c779d79c5cc8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:16:01Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cbc348d9d00c452dbd57c779d79c5cc82023-11-24T08:43:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221437210.3390/ijms232214372Hyaluronic Acid in Biomedical Fields: New Trends from Chemistry to Biomaterial ApplicationsAntonia Di Mola0Maria Rosaria Landi1Antonio Massa2Ugo D’Amora3Vincenzo Guarino4Dipartimento di Chimica e Biologia “A. Zambelli”, Università degli Studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, ItalyDipartimento di Chimica e Biologia “A. Zambelli”, Università degli Studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, ItalyDipartimento di Chimica e Biologia “A. Zambelli”, Università degli Studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, ItalyInstitute of Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra d’Otremare, Pad.20, V.le J.F. Kennedy 54, 80125 Naples, ItalyInstitute of Polymers, Composites and Biomaterials, National Research Council of Italy, Mostra d’Otremare, Pad.20, V.le J.F. Kennedy 54, 80125 Naples, ItalyThe aim of this review is to give an updated perspective about the methods for chemical modifications of hyaluronic acid (HA) toward the development of new applications in medical devices and material engineering. After a brief introduction on chemical, structural and biological features of this important natural polysaccharide, the most important methods for chemical and physical modifications are disclosed, discussing both on the formation of new covalent bonds and the interaction with other natural polysaccharides. These strategies are of paramount importance in the production of new medical devices and materials with improved properties. In particular, the use of HA in the development of new materials by means of additive manufacturing techniques as electro fluid dynamics, i.e., electrospinning for micro to nanofibres, and three-dimensional bioprinting is also discussed.https://www.mdpi.com/1422-0067/23/22/14372hyaluronic acidchemical and physical modificationcrosslinkingadditive manufacturingmedical and material engineering applications |
| spellingShingle | Antonia Di Mola Maria Rosaria Landi Antonio Massa Ugo D’Amora Vincenzo Guarino Hyaluronic Acid in Biomedical Fields: New Trends from Chemistry to Biomaterial Applications International Journal of Molecular Sciences hyaluronic acid chemical and physical modification crosslinking additive manufacturing medical and material engineering applications |
| title | Hyaluronic Acid in Biomedical Fields: New Trends from Chemistry to Biomaterial Applications |
| title_full | Hyaluronic Acid in Biomedical Fields: New Trends from Chemistry to Biomaterial Applications |
| title_fullStr | Hyaluronic Acid in Biomedical Fields: New Trends from Chemistry to Biomaterial Applications |
| title_full_unstemmed | Hyaluronic Acid in Biomedical Fields: New Trends from Chemistry to Biomaterial Applications |
| title_short | Hyaluronic Acid in Biomedical Fields: New Trends from Chemistry to Biomaterial Applications |
| title_sort | hyaluronic acid in biomedical fields new trends from chemistry to biomaterial applications |
| topic | hyaluronic acid chemical and physical modification crosslinking additive manufacturing medical and material engineering applications |
| url | https://www.mdpi.com/1422-0067/23/22/14372 |
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