Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020
ABSTRACT H10Nx influenza viruses have caused increasing public concern due to their occasional infection of humans. However, the genesis and biological characteristics of H10 viruses in migratory wild birds are largely unknown. In this study, we conducted active surveillance to monitor circulation o...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2022-04-01
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| Series: | Microbiology Spectrum |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/spectrum.00807-22 |
| _version_ | 1818141897915367424 |
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| author | Yanwen Wang Mengjing Wang Hong Zhang Conghui Zhao Yaping Zhang Guimei He Guohua Deng Pengfei Cui Yubao Li Wenqiang Liu Jinyan Shen Xiaohong Sun Wenting Wang Xianying Zeng Yanbing Li Dong Chu Peng Peng Jing Guo Hualan Chen Xuyong Li |
| author_facet | Yanwen Wang Mengjing Wang Hong Zhang Conghui Zhao Yaping Zhang Guimei He Guohua Deng Pengfei Cui Yubao Li Wenqiang Liu Jinyan Shen Xiaohong Sun Wenting Wang Xianying Zeng Yanbing Li Dong Chu Peng Peng Jing Guo Hualan Chen Xuyong Li |
| author_sort | Yanwen Wang |
| collection | DOAJ |
| description | ABSTRACT H10Nx influenza viruses have caused increasing public concern due to their occasional infection of humans. However, the genesis and biological characteristics of H10 viruses in migratory wild birds are largely unknown. In this study, we conducted active surveillance to monitor circulation of avian influenza viruses in eastern China and isolated five H10N4 and two H10N8 viruses from migratory birds in 2020. Genetic analysis indicated that the hemagglutinin (HA) genes of the seven H10 viruses were clustered into the North American lineage and established as a novel Eurasian branch in wild birds in South Korea, Bangladesh, and China. The neuraminidase (NA) genes of the H10N4 and H10N8 viruses originated from the circulating HxN4 and H5N8 viruses in migratory birds in Eurasia. We further revealed that some of the novel H10N4 and H10N8 viruses acquired the ability to bind human-like receptors. Animal studies indicated that these H10 viruses can replicate in mice, chickens, and ducks. Importantly, we found that the H10N4 and H10N8 viruses can transmit efficiently among chickens and ducks but induce lower HA inhibition (HI) antibody titers in ducks. These findings emphasized that annual surveillance in migratory waterfowl should be strengthened to monitor the introduction of wild-bird H10N4 and H10N8 reassortants into poultry. IMPORTANCE The emerging avian influenza reassortants and mutants in birds pose an increasing threat to poultry and public health. H10 avian influenza viruses are widely prevalent in wild birds, poultry, seals, and minks and pose an increasing threat to human health. The occasional human infections with H10N8 and H10N3 viruses in China have significantly increased public concern about the potential pandemic risk posed by H10 viruses. In this study, we found that the North American H10 viruses have been successfully introduced to Asia by migratory birds and further reassorted with other subtypes to generate novel H10N4 and H10N8 viruses in eastern China. These emerging H10 reassortants have a high potential to threaten the poultry industry and human health due to their efficient replication and transmission in chickens, ducks, and mice. |
| first_indexed | 2024-12-11T11:07:11Z |
| format | Article |
| id | doaj.art-cbc3f497c2f04075a3f120ca1316734d |
| institution | Directory Open Access Journal |
| issn | 2165-0497 |
| language | English |
| last_indexed | 2024-12-11T11:07:11Z |
| publishDate | 2022-04-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | Microbiology Spectrum |
| spelling | doaj.art-cbc3f497c2f04075a3f120ca1316734d2022-12-22T01:09:40ZengAmerican Society for MicrobiologyMicrobiology Spectrum2165-04972022-04-0110210.1128/spectrum.00807-22Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020Yanwen Wang0Mengjing Wang1Hong Zhang2Conghui Zhao3Yaping Zhang4Guimei He5Guohua Deng6Pengfei Cui7Yubao Li8Wenqiang Liu9Jinyan Shen10Xiaohong Sun11Wenting Wang12Xianying Zeng13Yanbing Li14Dong Chu15Peng Peng16Jing Guo17Hualan Chen18Xuyong Li19College of Agronomy, Liaocheng University, Liaocheng, ChinaCollege of Agronomy, Liaocheng University, Liaocheng, ChinaCollege of Agronomy, Liaocheng University, Liaocheng, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, ChinaInstitute of Eco-Chongming (IEC), East China Normal University, Shanghai, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, ChinaCollege of Agronomy, Liaocheng University, Liaocheng, ChinaCollege of Agronomy, Liaocheng University, Liaocheng, ChinaCollege of Agronomy, Liaocheng University, Liaocheng, ChinaCollege of Agronomy, Liaocheng University, Liaocheng, ChinaCollege of Agronomy, Liaocheng University, Liaocheng, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, ChinaNational Forestry and Grassland Administration, General Station for Surveillance of Wildlife Disease & Wildlife Borne Diseases, Shenyang, ChinaNational Forestry and Grassland Administration, General Station for Surveillance of Wildlife Disease & Wildlife Borne Diseases, Shenyang, ChinaCollege of Agronomy, Liaocheng University, Liaocheng, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, ChinaCollege of Agronomy, Liaocheng University, Liaocheng, ChinaABSTRACT H10Nx influenza viruses have caused increasing public concern due to their occasional infection of humans. However, the genesis and biological characteristics of H10 viruses in migratory wild birds are largely unknown. In this study, we conducted active surveillance to monitor circulation of avian influenza viruses in eastern China and isolated five H10N4 and two H10N8 viruses from migratory birds in 2020. Genetic analysis indicated that the hemagglutinin (HA) genes of the seven H10 viruses were clustered into the North American lineage and established as a novel Eurasian branch in wild birds in South Korea, Bangladesh, and China. The neuraminidase (NA) genes of the H10N4 and H10N8 viruses originated from the circulating HxN4 and H5N8 viruses in migratory birds in Eurasia. We further revealed that some of the novel H10N4 and H10N8 viruses acquired the ability to bind human-like receptors. Animal studies indicated that these H10 viruses can replicate in mice, chickens, and ducks. Importantly, we found that the H10N4 and H10N8 viruses can transmit efficiently among chickens and ducks but induce lower HA inhibition (HI) antibody titers in ducks. These findings emphasized that annual surveillance in migratory waterfowl should be strengthened to monitor the introduction of wild-bird H10N4 and H10N8 reassortants into poultry. IMPORTANCE The emerging avian influenza reassortants and mutants in birds pose an increasing threat to poultry and public health. H10 avian influenza viruses are widely prevalent in wild birds, poultry, seals, and minks and pose an increasing threat to human health. The occasional human infections with H10N8 and H10N3 viruses in China have significantly increased public concern about the potential pandemic risk posed by H10 viruses. In this study, we found that the North American H10 viruses have been successfully introduced to Asia by migratory birds and further reassorted with other subtypes to generate novel H10N4 and H10N8 viruses in eastern China. These emerging H10 reassortants have a high potential to threaten the poultry industry and human health due to their efficient replication and transmission in chickens, ducks, and mice.https://journals.asm.org/doi/10.1128/spectrum.00807-22H10N4H10N8avian influenza viruswild birdsreplication and transmission |
| spellingShingle | Yanwen Wang Mengjing Wang Hong Zhang Conghui Zhao Yaping Zhang Guimei He Guohua Deng Pengfei Cui Yubao Li Wenqiang Liu Jinyan Shen Xiaohong Sun Wenting Wang Xianying Zeng Yanbing Li Dong Chu Peng Peng Jing Guo Hualan Chen Xuyong Li Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020 Microbiology Spectrum H10N4 H10N8 avian influenza virus wild birds replication and transmission |
| title | Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020 |
| title_full | Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020 |
| title_fullStr | Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020 |
| title_full_unstemmed | Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020 |
| title_short | Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020 |
| title_sort | emergence evolution and biological characteristics of h10n4 and h10n8 avian influenza viruses in migratory wild birds detected in eastern china in 2020 |
| topic | H10N4 H10N8 avian influenza virus wild birds replication and transmission |
| url | https://journals.asm.org/doi/10.1128/spectrum.00807-22 |
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