A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion
Stress cardiomyopathy is a transient left ventricular dysfunction caused by physiologic or pathologic stressors. Anaphylaxis is a hypersensitivity disorder that can lead to a rapid life-threatening respiratory collapse. It happens due to exposure to allergens including medications. During anaphylaxi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-11-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/23247096231209554 |
| _version_ | 1797639949186498560 |
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| author | Harjinder Singh MD Omair Ahmed MD Erin Allen ACS Hussein Othman MD |
| author_facet | Harjinder Singh MD Omair Ahmed MD Erin Allen ACS Hussein Othman MD |
| author_sort | Harjinder Singh MD |
| collection | DOAJ |
| description | Stress cardiomyopathy is a transient left ventricular dysfunction caused by physiologic or pathologic stressors. Anaphylaxis is a hypersensitivity disorder that can lead to a rapid life-threatening respiratory collapse. It happens due to exposure to allergens including medications. During anaphylaxis, there is a compensatory release of catecholamines that can lead to stress cardiomyopathy. In this case, nab-paclitaxel infusion led to anaphylaxis with respiratory failure. Echocardiogram showed features of diffuse hypokinesis with preserved basal segment contractility, and cardiac catheterization did not show any evidence of obstructive coronary artery disease. The overall clinical picture suggested stress cardiomyopathy. The patient was treated with guideline-directed medical therapy which resulted in normalization of the ejection fraction with no symptoms of congestive heart failure at any point. The patient was thereafter resumed on a reduced dose of nab-paclitaxel. This case report adds to the spectrum of infusion-related reactions associated with paclitaxel and demonstrates the course of events in the management of anaphylaxis and stress cardiomyopathy in this scenario. |
| first_indexed | 2024-03-11T13:23:55Z |
| format | Article |
| id | doaj.art-cbc4037c726d48e982be972cd095d960 |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-03-11T13:23:55Z |
| publishDate | 2023-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-cbc4037c726d48e982be972cd095d9602023-11-03T10:03:36ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962023-11-011110.1177/23247096231209554A Case of Stress Cardiomyopathy With Nab-Paclitaxel InfusionHarjinder Singh MD0Omair Ahmed MD1Erin Allen ACS2Hussein Othman MD3Henry Ford Allegiance Health, Jackson, MI, USAHenry Ford Allegiance Health, Jackson, MI, USAHenry Ford Allegiance Health, Jackson, MI, USAHenry Ford Allegiance Health, Jackson, MI, USAStress cardiomyopathy is a transient left ventricular dysfunction caused by physiologic or pathologic stressors. Anaphylaxis is a hypersensitivity disorder that can lead to a rapid life-threatening respiratory collapse. It happens due to exposure to allergens including medications. During anaphylaxis, there is a compensatory release of catecholamines that can lead to stress cardiomyopathy. In this case, nab-paclitaxel infusion led to anaphylaxis with respiratory failure. Echocardiogram showed features of diffuse hypokinesis with preserved basal segment contractility, and cardiac catheterization did not show any evidence of obstructive coronary artery disease. The overall clinical picture suggested stress cardiomyopathy. The patient was treated with guideline-directed medical therapy which resulted in normalization of the ejection fraction with no symptoms of congestive heart failure at any point. The patient was thereafter resumed on a reduced dose of nab-paclitaxel. This case report adds to the spectrum of infusion-related reactions associated with paclitaxel and demonstrates the course of events in the management of anaphylaxis and stress cardiomyopathy in this scenario.https://doi.org/10.1177/23247096231209554 |
| spellingShingle | Harjinder Singh MD Omair Ahmed MD Erin Allen ACS Hussein Othman MD A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion Journal of Investigative Medicine High Impact Case Reports |
| title | A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion |
| title_full | A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion |
| title_fullStr | A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion |
| title_full_unstemmed | A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion |
| title_short | A Case of Stress Cardiomyopathy With Nab-Paclitaxel Infusion |
| title_sort | case of stress cardiomyopathy with nab paclitaxel infusion |
| url | https://doi.org/10.1177/23247096231209554 |
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