Study Protocol: Gut microbiota profiles implicated in the onset of autism spectrum disorders in preterm infants: A two-year follow-up study
Introduction Preterm infants are at high-risk of developing autism spectrum disorders (ASD). The underlying mechanisms that explain the link between prematurity and ASD are unclear. Perinatal environmental factors may disrupt the gut-brain communication, when the gut microbiome composition is estab...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822007064/type/journal_article |
| _version_ | 1827754477778632704 |
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| author | P. Navalón F. Ghosn B. Almansa I. Lara A. Pinilla Á. Solaz C. Zapata De Miguel Y. Cañada A. García-Blanco |
| author_facet | P. Navalón F. Ghosn B. Almansa I. Lara A. Pinilla Á. Solaz C. Zapata De Miguel Y. Cañada A. García-Blanco |
| author_sort | P. Navalón |
| collection | DOAJ |
| description |
Introduction
Preterm infants are at high-risk of developing autism spectrum disorders (ASD). The underlying mechanisms that explain the link between prematurity and ASD are unclear. Perinatal environmental factors may disrupt the gut-brain communication, when the gut microbiome composition is established and brain programming occurs. Therefore, the disruption of the gut-brain axis communication in response to perinatal environmental events may shed light on the association between prematurity and ASD.
Objectives
To describe a new research project protocol which aim is to develop a dynamic model of gut microbiota variation in response to environmental factors that modulate the ASD risk in preterm infants.
Methods
A two-year prospective observational study will be carried out, in which preterm infants will be assessed at birth, 40th postmenstrual week, at 6, 12, and 24 months of corrected age. Two-hundred preterm infants will be recruited. A comprehensive assessment will be conducted by collecting data on sociodemographic characteristics, medical history, family functioning, neurodevelopment, ASD screening, and diagnosis. Microbiome composition and microbial activity will be determined from feces.
Results
The expected results are: i) to characterize ASD since its early manifestations in an at-risk population, allowing an early diagnosis and intervention to improve clinical outcomes; ii) to identify early microbiota biomarkers in order to find potential pathophysiological pathways; iii) to understand the protective and risk factors associated to ASD since perinatal period.
Conclusions
A two-year predictive model will be generated based on environmental and gut microbiota variables. This predictive model of ASD would allow prevention, early diagnosis, improvement of prognosis, and personalized treatments in preterm infants.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:50:53Z |
| format | Article |
| id | doaj.art-cbc854fc877945f196a12e9deb95224e |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:50:53Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-cbc854fc877945f196a12e9deb95224e2023-11-17T05:06:53ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S276S27610.1192/j.eurpsy.2022.706Study Protocol: Gut microbiota profiles implicated in the onset of autism spectrum disorders in preterm infants: A two-year follow-up studyP. Navalón0F. Ghosn1B. Almansa2I. Lara3A. Pinilla4Á. Solaz5C. Zapata De Miguel6Y. Cañada7A. García-Blanco8La Fe Health Research Insitute, Neonatal Research Group, Valencia, SpainLa Fe Health Research Insitute, Neonatal Research Group, Valencia, SpainLa Fe Health Research Insitute, Neonatal Research Group, Valencia, SpainLa Fe Health Research Insitute, Neonatal Research Group, Valencia, SpainLa Fe Health Research Insitute, Neonatal Research Group, Valencia, SpainLa Fe Health Research Insitute, Neonatal Research Group, Valencia, SpainLa Fe Health Research Insitute, Neonatal Research Group, Valencia, SpainLa Fe Health Research Insitute, Mental Health Research Group, Valencia, SpainLa Fe Health Research Insitute, Neonatal Research Group, Valencia, Spain Introduction Preterm infants are at high-risk of developing autism spectrum disorders (ASD). The underlying mechanisms that explain the link between prematurity and ASD are unclear. Perinatal environmental factors may disrupt the gut-brain communication, when the gut microbiome composition is established and brain programming occurs. Therefore, the disruption of the gut-brain axis communication in response to perinatal environmental events may shed light on the association between prematurity and ASD. Objectives To describe a new research project protocol which aim is to develop a dynamic model of gut microbiota variation in response to environmental factors that modulate the ASD risk in preterm infants. Methods A two-year prospective observational study will be carried out, in which preterm infants will be assessed at birth, 40th postmenstrual week, at 6, 12, and 24 months of corrected age. Two-hundred preterm infants will be recruited. A comprehensive assessment will be conducted by collecting data on sociodemographic characteristics, medical history, family functioning, neurodevelopment, ASD screening, and diagnosis. Microbiome composition and microbial activity will be determined from feces. Results The expected results are: i) to characterize ASD since its early manifestations in an at-risk population, allowing an early diagnosis and intervention to improve clinical outcomes; ii) to identify early microbiota biomarkers in order to find potential pathophysiological pathways; iii) to understand the protective and risk factors associated to ASD since perinatal period. Conclusions A two-year predictive model will be generated based on environmental and gut microbiota variables. This predictive model of ASD would allow prevention, early diagnosis, improvement of prognosis, and personalized treatments in preterm infants. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822007064/type/journal_articleAutism Spectrum Disordersmicrobiotaprematurityfollow-up study |
| spellingShingle | P. Navalón F. Ghosn B. Almansa I. Lara A. Pinilla Á. Solaz C. Zapata De Miguel Y. Cañada A. García-Blanco Study Protocol: Gut microbiota profiles implicated in the onset of autism spectrum disorders in preterm infants: A two-year follow-up study European Psychiatry Autism Spectrum Disorders microbiota prematurity follow-up study |
| title | Study Protocol: Gut microbiota profiles implicated in the onset of autism spectrum disorders in preterm infants: A two-year follow-up study |
| title_full | Study Protocol: Gut microbiota profiles implicated in the onset of autism spectrum disorders in preterm infants: A two-year follow-up study |
| title_fullStr | Study Protocol: Gut microbiota profiles implicated in the onset of autism spectrum disorders in preterm infants: A two-year follow-up study |
| title_full_unstemmed | Study Protocol: Gut microbiota profiles implicated in the onset of autism spectrum disorders in preterm infants: A two-year follow-up study |
| title_short | Study Protocol: Gut microbiota profiles implicated in the onset of autism spectrum disorders in preterm infants: A two-year follow-up study |
| title_sort | study protocol gut microbiota profiles implicated in the onset of autism spectrum disorders in preterm infants a two year follow up study |
| topic | Autism Spectrum Disorders microbiota prematurity follow-up study |
| url | https://www.cambridge.org/core/product/identifier/S0924933822007064/type/journal_article |
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