Boron Neutron Capture Therapy for Breast Cancer during Pregnancy: A Feasibility Study
Introduction: the present study aimed to evaluate the feasibility of boron neutron capture therapy (BNCT) for breast cancer (BC) incidence during pregnancy. Material and Methods: Computational models of pregnant women at 3- and 6- month gestational ages were used with two different simulated tumors...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2020-11-01
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| Series: | Iranian Journal of Medical Physics |
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| Online Access: | http://ijmp.mums.ac.ir/article_14342_f12db2cc70026525efcf96d87138aba0.pdf |
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| author | Yasaman Rezaei Moghaddam Laleh Rafat Motavalli Seyed Hashem Miri-Hakimabad Elie Hoseinian-Azghadi |
| author_facet | Yasaman Rezaei Moghaddam Laleh Rafat Motavalli Seyed Hashem Miri-Hakimabad Elie Hoseinian-Azghadi |
| author_sort | Yasaman Rezaei Moghaddam |
| collection | DOAJ |
| description | Introduction: the present study aimed to evaluate the feasibility of boron neutron capture therapy (BNCT) for breast cancer (BC) incidence during pregnancy. Material and Methods: Computational models of pregnant women at 3- and 6- month gestational ages were used with two different simulated tumors in their left breasts. The Monte Carlo simulation of tumor irradiation by thermal and epithermal output beams of in-hospital neutron irradiator was performed in five directions. The optimum treatment plans as a combination of the irradiation directions and output beams were then assessed using an optimization code. Results: Based on the findings of the present study, the total irradiation time of ≤ 10 min was needed to deliver a prescribed dose of RX = 24.4 Gy-Eq to gross tumor volume (GTV) in a BNCT single fraction. The dosimetric properties and volume metrics of the optimized treatment plans were obtained and the dose-volume histogram (DVH)-based metrics, were compared to those from conventional radiotherapy. It has been shown that the dose to both target volume and organs at risk (OARs) were within clinically acceptable dose constraints throughout the course of a single- fraction BNCT. Moreover, the fetal dose (~4.8 mGy-Eq) was well below the threshold for secondary cancer incidence (10 mGy) in the first trimester of pregnancy, while for the second trimester of pregnancy, it was much higher (~35.5 mGy-Eq). Conclusion: Regarding the DVH metrics for GTV, maternal OARs, and the fetus, the studied treatment modality was an appropriate alternative treatment, especially for BC incidence in the first trimester of pregnancy. |
| first_indexed | 2024-12-22T19:57:41Z |
| format | Article |
| id | doaj.art-cbc8a65520694801a11c96972fbebe92 |
| institution | Directory Open Access Journal |
| issn | 2345-3672 2345-3672 |
| language | English |
| last_indexed | 2024-12-22T19:57:41Z |
| publishDate | 2020-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Physics |
| spelling | doaj.art-cbc8a65520694801a11c96972fbebe922022-12-21T18:14:23ZengMashhad University of Medical SciencesIranian Journal of Medical Physics2345-36722345-36722020-11-0117640140910.22038/ijmp.2019.42755.163914342Boron Neutron Capture Therapy for Breast Cancer during Pregnancy: A Feasibility StudyYasaman Rezaei Moghaddam0Laleh Rafat Motavalli1Seyed Hashem Miri-Hakimabad2Elie Hoseinian-Azghadi3Ferdowsi University of MashhadPhysics Department, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, IranPhysics Department, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, IranPhysics Department, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, IranIntroduction: the present study aimed to evaluate the feasibility of boron neutron capture therapy (BNCT) for breast cancer (BC) incidence during pregnancy. Material and Methods: Computational models of pregnant women at 3- and 6- month gestational ages were used with two different simulated tumors in their left breasts. The Monte Carlo simulation of tumor irradiation by thermal and epithermal output beams of in-hospital neutron irradiator was performed in five directions. The optimum treatment plans as a combination of the irradiation directions and output beams were then assessed using an optimization code. Results: Based on the findings of the present study, the total irradiation time of ≤ 10 min was needed to deliver a prescribed dose of RX = 24.4 Gy-Eq to gross tumor volume (GTV) in a BNCT single fraction. The dosimetric properties and volume metrics of the optimized treatment plans were obtained and the dose-volume histogram (DVH)-based metrics, were compared to those from conventional radiotherapy. It has been shown that the dose to both target volume and organs at risk (OARs) were within clinically acceptable dose constraints throughout the course of a single- fraction BNCT. Moreover, the fetal dose (~4.8 mGy-Eq) was well below the threshold for secondary cancer incidence (10 mGy) in the first trimester of pregnancy, while for the second trimester of pregnancy, it was much higher (~35.5 mGy-Eq). Conclusion: Regarding the DVH metrics for GTV, maternal OARs, and the fetus, the studied treatment modality was an appropriate alternative treatment, especially for BC incidence in the first trimester of pregnancy.http://ijmp.mums.ac.ir/article_14342_f12db2cc70026525efcf96d87138aba0.pdfboron neutron capture therapybreast cancerpregnancy |
| spellingShingle | Yasaman Rezaei Moghaddam Laleh Rafat Motavalli Seyed Hashem Miri-Hakimabad Elie Hoseinian-Azghadi Boron Neutron Capture Therapy for Breast Cancer during Pregnancy: A Feasibility Study Iranian Journal of Medical Physics boron neutron capture therapy breast cancer pregnancy |
| title | Boron Neutron Capture Therapy for Breast Cancer during Pregnancy: A Feasibility Study |
| title_full | Boron Neutron Capture Therapy for Breast Cancer during Pregnancy: A Feasibility Study |
| title_fullStr | Boron Neutron Capture Therapy for Breast Cancer during Pregnancy: A Feasibility Study |
| title_full_unstemmed | Boron Neutron Capture Therapy for Breast Cancer during Pregnancy: A Feasibility Study |
| title_short | Boron Neutron Capture Therapy for Breast Cancer during Pregnancy: A Feasibility Study |
| title_sort | boron neutron capture therapy for breast cancer during pregnancy a feasibility study |
| topic | boron neutron capture therapy breast cancer pregnancy |
| url | http://ijmp.mums.ac.ir/article_14342_f12db2cc70026525efcf96d87138aba0.pdf |
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