Novel insights into the epigenetics of diffuse glioma
Loss-of-function mutations of the chromatin regulator ATRX (α-thalassemia mental retardation X-linked) occur frequently in diffuse gliomas, but the molecular mechanisms by which ATRX inactivation promotes oncogenesis remain unclear. We recently reported that Atrx deficiency drives glioma-relevant ph...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-09-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1472055 |
| _version_ | 1797677171748110336 |
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| author | Carla Danussi Jason T. Huse |
| author_facet | Carla Danussi Jason T. Huse |
| author_sort | Carla Danussi |
| collection | DOAJ |
| description | Loss-of-function mutations of the chromatin regulator ATRX (α-thalassemia mental retardation X-linked) occur frequently in diffuse gliomas, but the molecular mechanisms by which ATRX inactivation promotes oncogenesis remain unclear. We recently reported that Atrx deficiency drives glioma-relevant phenotypes, such as increased motility and astrocytic differentiation profiles, by directly modulating epigenomic lanscapes in glioma cells of origin. Our work has significant implications on the role of epigenetic regulator dysfunction in the oncogenic process. |
| first_indexed | 2024-03-11T22:41:12Z |
| format | Article |
| id | doaj.art-cbc8d771285c4926aa39ab929aab9129 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:12Z |
| publishDate | 2018-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-cbc8d771285c4926aa39ab929aab91292023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-09-015510.1080/23723556.2018.14720551472055Novel insights into the epigenetics of diffuse gliomaCarla Danussi0Jason T. Huse1University of Texas MD Anderson Cancer CenterUniversity of Texas MD Anderson Cancer CenterLoss-of-function mutations of the chromatin regulator ATRX (α-thalassemia mental retardation X-linked) occur frequently in diffuse gliomas, but the molecular mechanisms by which ATRX inactivation promotes oncogenesis remain unclear. We recently reported that Atrx deficiency drives glioma-relevant phenotypes, such as increased motility and astrocytic differentiation profiles, by directly modulating epigenomic lanscapes in glioma cells of origin. Our work has significant implications on the role of epigenetic regulator dysfunction in the oncogenic process.http://dx.doi.org/10.1080/23723556.2018.1472055atrxgliomacancer genomicsepigenomicshistonesneuroepithelial progenitorsmigrationdifferentiation |
| spellingShingle | Carla Danussi Jason T. Huse Novel insights into the epigenetics of diffuse glioma Molecular & Cellular Oncology atrx glioma cancer genomics epigenomics histones neuroepithelial progenitors migration differentiation |
| title | Novel insights into the epigenetics of diffuse glioma |
| title_full | Novel insights into the epigenetics of diffuse glioma |
| title_fullStr | Novel insights into the epigenetics of diffuse glioma |
| title_full_unstemmed | Novel insights into the epigenetics of diffuse glioma |
| title_short | Novel insights into the epigenetics of diffuse glioma |
| title_sort | novel insights into the epigenetics of diffuse glioma |
| topic | atrx glioma cancer genomics epigenomics histones neuroepithelial progenitors migration differentiation |
| url | http://dx.doi.org/10.1080/23723556.2018.1472055 |
| work_keys_str_mv | AT carladanussi novelinsightsintotheepigeneticsofdiffuseglioma AT jasonthuse novelinsightsintotheepigeneticsofdiffuseglioma |