Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats
Purpose To demonstrate the effect of a 4% pulverized garlic supplemented diet on the nephrotoxicity induced by gentamicin in rats. Materials and Methods Twenty four healthy male Wistar rats, weighing between 220 - 260grams, were divided into three groups. The rats were randomly assigned to eithe...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2014-08-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382014000400562&lng=en&tlng=en |
| _version_ | 1818062677810872320 |
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| author | Ilker Seckiner Omer Bayrak Murat Can A. Gorkem Mungan N. Aydin Mungan |
| author_facet | Ilker Seckiner Omer Bayrak Murat Can A. Gorkem Mungan N. Aydin Mungan |
| author_sort | Ilker Seckiner |
| collection | DOAJ |
| description | Purpose To demonstrate the effect of a 4% pulverized garlic supplemented diet on the nephrotoxicity induced by gentamicin in rats. Materials and Methods Twenty four healthy male Wistar rats, weighing between 220 - 260grams, were divided into three groups. The rats were randomly assigned to either the gentamicin injection without garlic supplementation group (Group I, n = 8), gentamicin injection with garlic supplementation group (Group II, n = 8), and control group (Group III, n = 8). Urine from the rats was collected and the volume (mL), microalbumin (mg/L), creatinine (mg/dL), Na (mmol/L), K (mmol/L), Cl (mmol/L), P (mg/dL), N-acetyl glucosamine (NAG) (U/L) and pH values were measured. Then urea (mg/dL), creatinine (mg/dL), total protein (g/dL) and cystatin (mg/L) values were measured for the blood samples obtained from tail veins. Results The median NAG value for the control group (52.050 U/L) was similar to value for Group II (56.400 U/L), which received gentamicin and the garlic diet. However, the median NAG value for Group I (77.030 U/L), which received gentamicin without garlic supplementation, was determined to be statistically significantly higher (p = 0.010) than the value for the control group. In addition, the mean cystatin value for Group II (1.360 U/L) was found to be statistically significantly lower than the value for the Group I (2.240 U/L) (p = 0.015). Conclusions In this study we showed the effect of 4% pulverized garlic supplemented diet for preventing nephrotoxicity induced by gentamicin in rats by using as parameters NAG in urine samples and cystatin C in serum samples. |
| first_indexed | 2024-12-10T14:08:01Z |
| format | Article |
| id | doaj.art-cbcb219b304a45269a178ff23d389503 |
| institution | Directory Open Access Journal |
| issn | 1677-6119 |
| language | English |
| last_indexed | 2024-12-10T14:08:01Z |
| publishDate | 2014-08-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-cbcb219b304a45269a178ff23d3895032022-12-22T01:45:36ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-61192014-08-0140456256710.1590/S1677-5538.IBJU.2014.04.17S1677-55382014000400562Garlic supplemented diet attenuates gentamicin nephrotoxicity ın ratsIlker SeckinerOmer BayrakMurat CanA. Gorkem MunganN. Aydin MunganPurpose To demonstrate the effect of a 4% pulverized garlic supplemented diet on the nephrotoxicity induced by gentamicin in rats. Materials and Methods Twenty four healthy male Wistar rats, weighing between 220 - 260grams, were divided into three groups. The rats were randomly assigned to either the gentamicin injection without garlic supplementation group (Group I, n = 8), gentamicin injection with garlic supplementation group (Group II, n = 8), and control group (Group III, n = 8). Urine from the rats was collected and the volume (mL), microalbumin (mg/L), creatinine (mg/dL), Na (mmol/L), K (mmol/L), Cl (mmol/L), P (mg/dL), N-acetyl glucosamine (NAG) (U/L) and pH values were measured. Then urea (mg/dL), creatinine (mg/dL), total protein (g/dL) and cystatin (mg/L) values were measured for the blood samples obtained from tail veins. Results The median NAG value for the control group (52.050 U/L) was similar to value for Group II (56.400 U/L), which received gentamicin and the garlic diet. However, the median NAG value for Group I (77.030 U/L), which received gentamicin without garlic supplementation, was determined to be statistically significantly higher (p = 0.010) than the value for the control group. In addition, the mean cystatin value for Group II (1.360 U/L) was found to be statistically significantly lower than the value for the Group I (2.240 U/L) (p = 0.015). Conclusions In this study we showed the effect of 4% pulverized garlic supplemented diet for preventing nephrotoxicity induced by gentamicin in rats by using as parameters NAG in urine samples and cystatin C in serum samples.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382014000400562&lng=en&tlng=engarlicgentamicinnephrotoxicityNAGcystatin |
| spellingShingle | Ilker Seckiner Omer Bayrak Murat Can A. Gorkem Mungan N. Aydin Mungan Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats International Brazilian Journal of Urology garlic gentamicin nephrotoxicity NAG cystatin |
| title | Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats |
| title_full | Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats |
| title_fullStr | Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats |
| title_full_unstemmed | Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats |
| title_short | Garlic supplemented diet attenuates gentamicin nephrotoxicity ın rats |
| title_sort | garlic supplemented diet attenuates gentamicin nephrotoxicity in rats |
| topic | garlic gentamicin nephrotoxicity NAG cystatin |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382014000400562&lng=en&tlng=en |
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