Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity
Cyclodipeptides (CDPs) or diketopiperazines (DKPs) are often found in nature and in foodstuff and beverages and have attracted great interest for their bioactivities, biocompatibility, and biodegradability. In the laboratory, they can be prepared by green procedures, such as microwave-assisted cycli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2342 |
| _version_ | 1827651480413274112 |
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| author | Veronica Mosetti Beatrice Rosetti Giovanni Pierri Ottavia Bellotto Simone Adorinni Antonella Bandiera Gianpiero Adami Consiglia Tedesco Matteo Crosera Greta Camilla Magnano Silvia Marchesan |
| author_facet | Veronica Mosetti Beatrice Rosetti Giovanni Pierri Ottavia Bellotto Simone Adorinni Antonella Bandiera Gianpiero Adami Consiglia Tedesco Matteo Crosera Greta Camilla Magnano Silvia Marchesan |
| author_sort | Veronica Mosetti |
| collection | DOAJ |
| description | Cyclodipeptides (CDPs) or diketopiperazines (DKPs) are often found in nature and in foodstuff and beverages and have attracted great interest for their bioactivities, biocompatibility, and biodegradability. In the laboratory, they can be prepared by green procedures, such as microwave-assisted cyclization of linear dipeptides in water, as performed in this study. In particular, five CDPs were prepared and characterized by a variety of methods, including NMR and ESI-MS spectroscopies and single-crystal X-ray diffraction (XRD), and their cytocompatibility and anti-aging activity was tested in vitro, as well as their ability to penetrate the different layers of the skin. Although their mechanism of action remains to be elucidated, this proof-of-concept study lays the basis for their future use in anti-age cosmetic applications. |
| first_indexed | 2024-03-09T20:40:15Z |
| format | Article |
| id | doaj.art-cbcbadf1568e40daab7e106334626bf6 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:40:15Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-cbcbadf1568e40daab7e106334626bf62023-11-23T23:01:29ZengMDPI AGBiomedicines2227-90592022-09-011010234210.3390/biomedicines10102342Cyclodipeptides: From Their Green Synthesis to Anti-Age ActivityVeronica Mosetti0Beatrice Rosetti1Giovanni Pierri2Ottavia Bellotto3Simone Adorinni4Antonella Bandiera5Gianpiero Adami6Consiglia Tedesco7Matteo Crosera8Greta Camilla Magnano9Silvia Marchesan10Chemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, ItalyChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, ItalyDepartment of Chemistry and Biology “A. Zambelli”, University of Salerno, 84084 Fisciano, ItalyChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, ItalyChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, ItalyLife Sciences Department, University of Trieste, 34127 Trieste, ItalyChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, ItalyDepartment of Chemistry and Biology “A. Zambelli”, University of Salerno, 84084 Fisciano, ItalyChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, ItalyChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, ItalyChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, ItalyCyclodipeptides (CDPs) or diketopiperazines (DKPs) are often found in nature and in foodstuff and beverages and have attracted great interest for their bioactivities, biocompatibility, and biodegradability. In the laboratory, they can be prepared by green procedures, such as microwave-assisted cyclization of linear dipeptides in water, as performed in this study. In particular, five CDPs were prepared and characterized by a variety of methods, including NMR and ESI-MS spectroscopies and single-crystal X-ray diffraction (XRD), and their cytocompatibility and anti-aging activity was tested in vitro, as well as their ability to penetrate the different layers of the skin. Although their mechanism of action remains to be elucidated, this proof-of-concept study lays the basis for their future use in anti-age cosmetic applications.https://www.mdpi.com/2227-9059/10/10/2342cyclodipeptidesdiketopiperazinesanti-agecosmeticspeptidesgreen synthesis |
| spellingShingle | Veronica Mosetti Beatrice Rosetti Giovanni Pierri Ottavia Bellotto Simone Adorinni Antonella Bandiera Gianpiero Adami Consiglia Tedesco Matteo Crosera Greta Camilla Magnano Silvia Marchesan Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity Biomedicines cyclodipeptides diketopiperazines anti-age cosmetics peptides green synthesis |
| title | Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity |
| title_full | Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity |
| title_fullStr | Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity |
| title_full_unstemmed | Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity |
| title_short | Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity |
| title_sort | cyclodipeptides from their green synthesis to anti age activity |
| topic | cyclodipeptides diketopiperazines anti-age cosmetics peptides green synthesis |
| url | https://www.mdpi.com/2227-9059/10/10/2342 |
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