Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity
Adenylate cyclase toxin (CyaA) is released in the course of B. pertussis infection in the host’s respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. CD11b-expressing dendritic cells (DC), macrophages and neutrophils are professional phagocytes and key play...
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| Format: | Article |
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MDPI AG
2017-09-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/9/10/293 |
| _version_ | 1797999918222147584 |
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| author | Giorgio Fedele Ilaria Schiavoni Irena Adkins Nela Klimova Peter Sebo |
| author_facet | Giorgio Fedele Ilaria Schiavoni Irena Adkins Nela Klimova Peter Sebo |
| author_sort | Giorgio Fedele |
| collection | DOAJ |
| description | Adenylate cyclase toxin (CyaA) is released in the course of B. pertussis infection in the host’s respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. CD11b-expressing dendritic cells (DC), macrophages and neutrophils are professional phagocytes and key players of the innate immune system that provide a first line of defense against invading pathogens. Recent findings revealed the capacity of B. pertussis CyaA to intoxicate DC with high concentrations of 3′,5′-cyclic adenosine monophosphate (cAMP), which ultimately skews the host immune response towards the expansion of Th17 cells and regulatory T cells. CyaA-induced cAMP signaling swiftly incapacitates opsonophagocytosis, oxidative burst and NO-mediated killing of bacteria by neutrophils and macrophages. The subversion of host immune responses by CyaA after delivery into DC, macrophages and neutrophils is the subject of this review. |
| first_indexed | 2024-04-11T11:12:13Z |
| format | Article |
| id | doaj.art-cbcc855362af4bb1b8135aad040f7b74 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T11:12:13Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-cbcc855362af4bb1b8135aad040f7b742022-12-22T04:27:26ZengMDPI AGToxins2072-66512017-09-0191029310.3390/toxins9100293toxins9100293Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host ImmunityGiorgio Fedele0Ilaria Schiavoni1Irena Adkins2Nela Klimova3Peter Sebo4Department of Infectious Diseases, Istituto Superiore di Sanità, Rome 00161, ItalyDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome 00161, ItalySotio a.s, Prague170 00, Czech RepublicInstitute of Microbiology of the CAS, v. v. i., Prague 142 20, Czech RepublicInstitute of Microbiology of the CAS, v. v. i., Prague 142 20, Czech RepublicAdenylate cyclase toxin (CyaA) is released in the course of B. pertussis infection in the host’s respiratory tract in order to suppress its early innate and subsequent adaptive immune defense. CD11b-expressing dendritic cells (DC), macrophages and neutrophils are professional phagocytes and key players of the innate immune system that provide a first line of defense against invading pathogens. Recent findings revealed the capacity of B. pertussis CyaA to intoxicate DC with high concentrations of 3′,5′-cyclic adenosine monophosphate (cAMP), which ultimately skews the host immune response towards the expansion of Th17 cells and regulatory T cells. CyaA-induced cAMP signaling swiftly incapacitates opsonophagocytosis, oxidative burst and NO-mediated killing of bacteria by neutrophils and macrophages. The subversion of host immune responses by CyaA after delivery into DC, macrophages and neutrophils is the subject of this review.https://www.mdpi.com/2072-6651/9/10/293immune responseintracellular pathwaysphagocytosisT-helper cells |
| spellingShingle | Giorgio Fedele Ilaria Schiavoni Irena Adkins Nela Klimova Peter Sebo Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity Toxins immune response intracellular pathways phagocytosis T-helper cells |
| title | Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity |
| title_full | Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity |
| title_fullStr | Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity |
| title_full_unstemmed | Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity |
| title_short | Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity |
| title_sort | invasion of dendritic cells macrophages and neutrophils by the bordetella adenylate cyclase toxin a subversive move to fool host immunity |
| topic | immune response intracellular pathways phagocytosis T-helper cells |
| url | https://www.mdpi.com/2072-6651/9/10/293 |
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