Development and implementation of “handshake rounds”: An antibiotic stewardship intervention for hospitalized adult patients with hematologic malignancies
Abstract Objective: To design and implement “handshake rounds” as an antibiotic stewardship intervention to reduce inpatient intravenous (IV) antibiotic use in patients with hematologic malignancies. Design: Quasi-experimental analysis of antibiotic use (AU) and secondary outcomes before and and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2023-01-01
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| Series: | Antimicrobial Stewardship & Healthcare Epidemiology |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2732494X23001250/type/journal_article |
| _version_ | 1797845429421867008 |
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| author | Chelsea A. Gorsline Ryan M. Miller Laura J. Bobbitt Gowri Satyanarayana Muhamed Baljevic Milner B. O. Staub |
| author_facet | Chelsea A. Gorsline Ryan M. Miller Laura J. Bobbitt Gowri Satyanarayana Muhamed Baljevic Milner B. O. Staub |
| author_sort | Chelsea A. Gorsline |
| collection | DOAJ |
| description |
Abstract
Objective:
To design and implement “handshake rounds” as an antibiotic stewardship intervention to reduce inpatient intravenous (IV) antibiotic use in patients with hematologic malignancies.
Design:
Quasi-experimental analysis of antibiotic use (AU) and secondary outcomes before and and after handshake rounds were implemented.
Setting:
Quaternary-care, academic medical center.
Patients:
Hospitalized adults with hematologic malignancies receiving IV antibiotics.
Methods:
We performed a retrospective review of a preintervention cohort prior to the intervention. A multidisciplinary team developed criteria for de-escalation of antibiotics, logistics of handshake rounds, and outcome metrics. Eligible patients were discussed during scheduled handshake rounds between a hematology–oncology pharmacist and transplant–infectious diseases (TID) physician. Prospective data were collected over 30 days in the postintervention cohort. Due to small sample size, 2:1 matching was used to compare pre- to and postintervention AU. Total AU in days of therapy per 1,000 patient days (DOT/1,000 PD) was reported. Mean AU per patient was analyzed using Wilcoxon rank-sum test. A descriptive analysis of secondary outcomes of pre- and postintervention cohorts was performed.
Results:
Total AU was substantially lower after the intervention, with 517 DOT/1,000 PD compared to 865 DOT/1,000 PD before the intervention. There was no statistically significant difference in the mean AU per patient between the 2 cohorts. There was a lower rate of 30-day mortality in the postintervention cohort and rates of ICU admissions were similar.
Conclusions:
Conducting handshake rounds is a safe and effective way to implement an antibiotic stewardship intervention among high-risk patient population such as those with hematologic malignancies.
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| first_indexed | 2024-04-09T17:38:52Z |
| format | Article |
| id | doaj.art-cbd0481aac8a4e3589e893ac25c2f6af |
| institution | Directory Open Access Journal |
| issn | 2732-494X |
| language | English |
| last_indexed | 2024-04-09T17:38:52Z |
| publishDate | 2023-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Antimicrobial Stewardship & Healthcare Epidemiology |
| spelling | doaj.art-cbd0481aac8a4e3589e893ac25c2f6af2023-04-17T08:07:23ZengCambridge University PressAntimicrobial Stewardship & Healthcare Epidemiology2732-494X2023-01-01310.1017/ash.2023.125Development and implementation of “handshake rounds”: An antibiotic stewardship intervention for hospitalized adult patients with hematologic malignanciesChelsea A. Gorsline0https://orcid.org/0000-0002-1068-2493Ryan M. Miller1Laura J. Bobbitt2https://orcid.org/0000-0003-2386-9318Gowri Satyanarayana3Muhamed Baljevic4https://orcid.org/0000-0002-0630-8458Milner B. O. Staub5https://orcid.org/0000-0002-0774-7698Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee Division of Infectious Diseases, Department of Medicine, University of Kansas Medical Center, Kansas City, KansasDepartment of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, TennesseeDepartment of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, TennesseeNorthside Hospital, Atlanta, GeorgiaDivision of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TennesseeDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee Abstract Objective: To design and implement “handshake rounds” as an antibiotic stewardship intervention to reduce inpatient intravenous (IV) antibiotic use in patients with hematologic malignancies. Design: Quasi-experimental analysis of antibiotic use (AU) and secondary outcomes before and and after handshake rounds were implemented. Setting: Quaternary-care, academic medical center. Patients: Hospitalized adults with hematologic malignancies receiving IV antibiotics. Methods: We performed a retrospective review of a preintervention cohort prior to the intervention. A multidisciplinary team developed criteria for de-escalation of antibiotics, logistics of handshake rounds, and outcome metrics. Eligible patients were discussed during scheduled handshake rounds between a hematology–oncology pharmacist and transplant–infectious diseases (TID) physician. Prospective data were collected over 30 days in the postintervention cohort. Due to small sample size, 2:1 matching was used to compare pre- to and postintervention AU. Total AU in days of therapy per 1,000 patient days (DOT/1,000 PD) was reported. Mean AU per patient was analyzed using Wilcoxon rank-sum test. A descriptive analysis of secondary outcomes of pre- and postintervention cohorts was performed. Results: Total AU was substantially lower after the intervention, with 517 DOT/1,000 PD compared to 865 DOT/1,000 PD before the intervention. There was no statistically significant difference in the mean AU per patient between the 2 cohorts. There was a lower rate of 30-day mortality in the postintervention cohort and rates of ICU admissions were similar. Conclusions: Conducting handshake rounds is a safe and effective way to implement an antibiotic stewardship intervention among high-risk patient population such as those with hematologic malignancies. https://www.cambridge.org/core/product/identifier/S2732494X23001250/type/journal_article |
| spellingShingle | Chelsea A. Gorsline Ryan M. Miller Laura J. Bobbitt Gowri Satyanarayana Muhamed Baljevic Milner B. O. Staub Development and implementation of “handshake rounds”: An antibiotic stewardship intervention for hospitalized adult patients with hematologic malignancies Antimicrobial Stewardship & Healthcare Epidemiology |
| title | Development and implementation of “handshake rounds”: An antibiotic stewardship intervention for hospitalized adult patients with hematologic malignancies |
| title_full | Development and implementation of “handshake rounds”: An antibiotic stewardship intervention for hospitalized adult patients with hematologic malignancies |
| title_fullStr | Development and implementation of “handshake rounds”: An antibiotic stewardship intervention for hospitalized adult patients with hematologic malignancies |
| title_full_unstemmed | Development and implementation of “handshake rounds”: An antibiotic stewardship intervention for hospitalized adult patients with hematologic malignancies |
| title_short | Development and implementation of “handshake rounds”: An antibiotic stewardship intervention for hospitalized adult patients with hematologic malignancies |
| title_sort | development and implementation of handshake rounds an antibiotic stewardship intervention for hospitalized adult patients with hematologic malignancies |
| url | https://www.cambridge.org/core/product/identifier/S2732494X23001250/type/journal_article |
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