Stereocomplexation Reinforced High Strength Poly(L-lactide)/Nanohydroxyapatite Composites for Potential Bone Repair Applications
Composite materials composed of polylactide (PLA) and nano-hydroxyapatite (n-HA) have been recognized as excellent candidate material in bone repai The difference in hydrophilicity/hydrophobicity and poor interfacial compatibility between n-HA filler and PLA matrix leads to non-uniform dispersion of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/14/3/645 |
| _version_ | 1797485179115143168 |
|---|---|
| author | Naishun Guo Mengen Zhao Sijing Li Jiahui Hao Zhaoying Wu Chao Zhang |
| author_facet | Naishun Guo Mengen Zhao Sijing Li Jiahui Hao Zhaoying Wu Chao Zhang |
| author_sort | Naishun Guo |
| collection | DOAJ |
| description | Composite materials composed of polylactide (PLA) and nano-hydroxyapatite (n-HA) have been recognized as excellent candidate material in bone repai The difference in hydrophilicity/hydrophobicity and poor interfacial compatibility between n-HA filler and PLA matrix leads to non-uniform dispersion of n-HA in PLA matrix and consequent poor reinforcement effect. In this study, an HA/PLA nanocomposite was designed based on the surface modification of n-HA with poly(D-lactide) (PDLA), which not only can improve the dispersion of n-HA in the poly(L-lactide) (PLLA) matrix but also could form a stereocomplex crystal with the matrix PLLA at the interface and ultimately lead to greatly enhanced mechanical performance The n-HA/PLA composites were characterized by means of scanning electron microscopy, Fourier transform infrared spectroscopy, X-Ray diffraction, thermal gravity analysis, differential scanning calorimetry, and a mechanical test; in vitro cytotoxicity of the composite material as well as its efficacy in inducing osteogenic differentiation of rat bone marrow stromal cells (rMSCs) were also evaluated. Compared with those of neat PLLA, the tensile strength, Young’s modulus, interfacial shear strength, elongation at break and crystallinity of the composites increased by 34%, 53%, 26%, 70%, and 17%, respectively. The adhesion and proliferation as well as the osteogenic differentiation of rMSCs on HA/PLA composites were clearly evidenced. Therefore, the HA/PLA composites have great potential for bone repai. |
| first_indexed | 2024-03-09T23:16:00Z |
| format | Article |
| id | doaj.art-cbd0683fd7a74a3d8f92bb50b53f827a |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T23:16:00Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-cbd0683fd7a74a3d8f92bb50b53f827a2023-11-23T17:37:26ZengMDPI AGPolymers2073-43602022-02-0114364510.3390/polym14030645Stereocomplexation Reinforced High Strength Poly(L-lactide)/Nanohydroxyapatite Composites for Potential Bone Repair ApplicationsNaishun Guo0Mengen Zhao1Sijing Li2Jiahui Hao3Zhaoying Wu4Chao Zhang5School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, ChinaComposite materials composed of polylactide (PLA) and nano-hydroxyapatite (n-HA) have been recognized as excellent candidate material in bone repai The difference in hydrophilicity/hydrophobicity and poor interfacial compatibility between n-HA filler and PLA matrix leads to non-uniform dispersion of n-HA in PLA matrix and consequent poor reinforcement effect. In this study, an HA/PLA nanocomposite was designed based on the surface modification of n-HA with poly(D-lactide) (PDLA), which not only can improve the dispersion of n-HA in the poly(L-lactide) (PLLA) matrix but also could form a stereocomplex crystal with the matrix PLLA at the interface and ultimately lead to greatly enhanced mechanical performance The n-HA/PLA composites were characterized by means of scanning electron microscopy, Fourier transform infrared spectroscopy, X-Ray diffraction, thermal gravity analysis, differential scanning calorimetry, and a mechanical test; in vitro cytotoxicity of the composite material as well as its efficacy in inducing osteogenic differentiation of rat bone marrow stromal cells (rMSCs) were also evaluated. Compared with those of neat PLLA, the tensile strength, Young’s modulus, interfacial shear strength, elongation at break and crystallinity of the composites increased by 34%, 53%, 26%, 70%, and 17%, respectively. The adhesion and proliferation as well as the osteogenic differentiation of rMSCs on HA/PLA composites were clearly evidenced. Therefore, the HA/PLA composites have great potential for bone repai.https://www.mdpi.com/2073-4360/14/3/645polylactidehydroxyapatitenanocompositestereocomplexmechanical property |
| spellingShingle | Naishun Guo Mengen Zhao Sijing Li Jiahui Hao Zhaoying Wu Chao Zhang Stereocomplexation Reinforced High Strength Poly(L-lactide)/Nanohydroxyapatite Composites for Potential Bone Repair Applications Polymers polylactide hydroxyapatite nanocomposite stereocomplex mechanical property |
| title | Stereocomplexation Reinforced High Strength Poly(L-lactide)/Nanohydroxyapatite Composites for Potential Bone Repair Applications |
| title_full | Stereocomplexation Reinforced High Strength Poly(L-lactide)/Nanohydroxyapatite Composites for Potential Bone Repair Applications |
| title_fullStr | Stereocomplexation Reinforced High Strength Poly(L-lactide)/Nanohydroxyapatite Composites for Potential Bone Repair Applications |
| title_full_unstemmed | Stereocomplexation Reinforced High Strength Poly(L-lactide)/Nanohydroxyapatite Composites for Potential Bone Repair Applications |
| title_short | Stereocomplexation Reinforced High Strength Poly(L-lactide)/Nanohydroxyapatite Composites for Potential Bone Repair Applications |
| title_sort | stereocomplexation reinforced high strength poly l lactide nanohydroxyapatite composites for potential bone repair applications |
| topic | polylactide hydroxyapatite nanocomposite stereocomplex mechanical property |
| url | https://www.mdpi.com/2073-4360/14/3/645 |
| work_keys_str_mv | AT naishunguo stereocomplexationreinforcedhighstrengthpolyllactidenanohydroxyapatitecompositesforpotentialbonerepairapplications AT mengenzhao stereocomplexationreinforcedhighstrengthpolyllactidenanohydroxyapatitecompositesforpotentialbonerepairapplications AT sijingli stereocomplexationreinforcedhighstrengthpolyllactidenanohydroxyapatitecompositesforpotentialbonerepairapplications AT jiahuihao stereocomplexationreinforcedhighstrengthpolyllactidenanohydroxyapatitecompositesforpotentialbonerepairapplications AT zhaoyingwu stereocomplexationreinforcedhighstrengthpolyllactidenanohydroxyapatitecompositesforpotentialbonerepairapplications AT chaozhang stereocomplexationreinforcedhighstrengthpolyllactidenanohydroxyapatitecompositesforpotentialbonerepairapplications |