The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI
The intervertebral disc (IVD) plays a main role in absorbing and transmitting loads within the spinal column. Degeneration alters the structural integrity of the IVDs and causes pain, especially in the lumbar region. The objective of this study was to investigate non-invasively the effect of degener...
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2020.610907/full |
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| author | Saman Tavana Spyros D. Masouros Nicoleta Baxan Brett A. Freedman Ulrich N. Hansen Nicolas Newell |
| author_facet | Saman Tavana Spyros D. Masouros Nicoleta Baxan Brett A. Freedman Ulrich N. Hansen Nicolas Newell |
| author_sort | Saman Tavana |
| collection | DOAJ |
| description | The intervertebral disc (IVD) plays a main role in absorbing and transmitting loads within the spinal column. Degeneration alters the structural integrity of the IVDs and causes pain, especially in the lumbar region. The objective of this study was to investigate non-invasively the effect of degeneration on human 3D lumbar IVD strains (n = 8) and the mechanism of spinal failure (n = 10) under pure axial compression using digital volume correlation (DVC) and 9.4 Tesla magnetic resonance imaging (MRI). Degenerate IVDs had higher (p < 0.05) axial strains (58% higher), maximum 3D compressive strains (43% higher), and maximum 3D shear strains (41% higher), in comparison to the non-degenerate IVDs, particularly in the lateral and posterior annulus. In both degenerate and non-degenerate IVDs, peak tensile and shear strains were observed close to the endplates. Inward bulging of the inner annulus was observed in all degenerate IVDs causing an increase in the AF compressive, tensile, and shear strains at the site of inward bulge, which may predispose it to circumferential tears (delamination). The endplate is the spine's “weak link” in pure axial compression, and the mechanism of human vertebral fracture is associated with disc degeneration. In non-degenerate IVDs the locations of failure were close to the endplate centroid, whereas in degenerate IVDs they were in peripheral regions. These findings advance the state of knowledge on mechanical changes during degeneration of the IVD, which help reduce the risk of injury, optimize treatments, and improve spinal implant designs. Additionally, these new data can be used to validate computational models. |
| first_indexed | 2024-12-20T02:01:51Z |
| format | Article |
| id | doaj.art-cbd28be4657e4e888956e72ed919d80a |
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| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-20T02:01:51Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-cbd28be4657e4e888956e72ed919d80a2022-12-21T19:57:18ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-01-01810.3389/fbioe.2020.610907610907The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRISaman Tavana0Spyros D. Masouros1Nicoleta Baxan2Brett A. Freedman3Ulrich N. Hansen4Nicolas Newell5Biomechanics Group, Department of Mechanical Engineering, Imperial College London, London, United KingdomRoyal British Legion Centre for Blast Injuries Studies, Department of Bioengineering, Imperial College London, London, United KingdomBiological Imaging Centre, Central Biomedical Services, Imperial College London, Hammersmith Hospital Campus, London, United KingdomDepartment of Orthopaedic Surgery, Mayo Clinic, Rochester, MN, United StatesBiomechanics Group, Department of Mechanical Engineering, Imperial College London, London, United KingdomBiomechanics Group, Department of Mechanical Engineering, Imperial College London, London, United KingdomThe intervertebral disc (IVD) plays a main role in absorbing and transmitting loads within the spinal column. Degeneration alters the structural integrity of the IVDs and causes pain, especially in the lumbar region. The objective of this study was to investigate non-invasively the effect of degeneration on human 3D lumbar IVD strains (n = 8) and the mechanism of spinal failure (n = 10) under pure axial compression using digital volume correlation (DVC) and 9.4 Tesla magnetic resonance imaging (MRI). Degenerate IVDs had higher (p < 0.05) axial strains (58% higher), maximum 3D compressive strains (43% higher), and maximum 3D shear strains (41% higher), in comparison to the non-degenerate IVDs, particularly in the lateral and posterior annulus. In both degenerate and non-degenerate IVDs, peak tensile and shear strains were observed close to the endplates. Inward bulging of the inner annulus was observed in all degenerate IVDs causing an increase in the AF compressive, tensile, and shear strains at the site of inward bulge, which may predispose it to circumferential tears (delamination). The endplate is the spine's “weak link” in pure axial compression, and the mechanism of human vertebral fracture is associated with disc degeneration. In non-degenerate IVDs the locations of failure were close to the endplate centroid, whereas in degenerate IVDs they were in peripheral regions. These findings advance the state of knowledge on mechanical changes during degeneration of the IVD, which help reduce the risk of injury, optimize treatments, and improve spinal implant designs. Additionally, these new data can be used to validate computational models.https://www.frontiersin.org/articles/10.3389/fbioe.2020.610907/fulldisc degenerationdigital volume correlation (DVC)internal 3D strainvertebral fracturemagnetic resonace imaging (MRI)endplate fracture |
| spellingShingle | Saman Tavana Spyros D. Masouros Nicoleta Baxan Brett A. Freedman Ulrich N. Hansen Nicolas Newell The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI Frontiers in Bioengineering and Biotechnology disc degeneration digital volume correlation (DVC) internal 3D strain vertebral fracture magnetic resonace imaging (MRI) endplate fracture |
| title | The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI |
| title_full | The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI |
| title_fullStr | The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI |
| title_full_unstemmed | The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI |
| title_short | The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI |
| title_sort | effect of degeneration on internal strains and the mechanism of failure in human intervertebral discs analyzed using digital volume correlation dvc and ultra high field mri |
| topic | disc degeneration digital volume correlation (DVC) internal 3D strain vertebral fracture magnetic resonace imaging (MRI) endplate fracture |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2020.610907/full |
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