A pilot study to explore the effect of udenafil on cerebral hemodynamics in older adults
Abstract Objective Phosphodiesterase‐5 inhibitors (PDE5Is) enhance vasodilation. We investigated the effects of PDE5I on cerebral hemodynamics during cognitive tasks using functional near‐infrared spectroscopy (fNIRS). Methods This study used a crossover design. Twelve cognitively healthy men partic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51774 |
| _version_ | 1797803352970493952 |
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| author | Qi Wang Byoung‐Soo Shin Sun‐Young Oh Yu Seob Shin Duk L. Na Ko Woon Kim |
| author_facet | Qi Wang Byoung‐Soo Shin Sun‐Young Oh Yu Seob Shin Duk L. Na Ko Woon Kim |
| author_sort | Qi Wang |
| collection | DOAJ |
| description | Abstract Objective Phosphodiesterase‐5 inhibitors (PDE5Is) enhance vasodilation. We investigated the effects of PDE5I on cerebral hemodynamics during cognitive tasks using functional near‐infrared spectroscopy (fNIRS). Methods This study used a crossover design. Twelve cognitively healthy men participants (mean age, 59 ± 3 years; range, 55–65 years) were recruited and randomly assigned to the experimental or control arm, then the experimental and control arm were exchanged after 1 week. Udenafil 100 mg was administered to participants in the experimental arm once daily for 3 days. We measured the fNIRS signal during the resting state and four cognitive tasks three times for each participant: at baseline, in the experimental arm, and in the control arm. Results Behavioral data did not show a significant difference between the experimental and control arms. The fNIRS signal showed significant decreases in the experimental arm compared to the control arm during several cognitive tests: verbal fluency test (left dorsolateral prefrontal cortex, T = −3.02, p = 0.014; left frontopolar cortex, T = −4.37, p = 0.002; right dorsolateral prefrontal cortex, T = −2.59, p = 0.027), Korean‐color word Stroop test (left orbitofrontal cortex, T = −3.61, p = 0.009), and social event memory test (left dorsolateral prefrontal cortex, T = −2.35, p = 0.043; left frontopolar cortex, T = −3.35, p = 0.01). Interpretation Our results showed a paradoxical effect of udenafil on cerebral hemodynamics in older adults. This contradicts our hypothesis, but it suggests that fNIRS is sensitive to changes in cerebral hemodynamics in response to PDE5Is. |
| first_indexed | 2024-03-13T05:19:34Z |
| format | Article |
| id | doaj.art-cbd2e5436e3f4e8f82a4e28d7d8c3b09 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-03-13T05:19:34Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-cbd2e5436e3f4e8f82a4e28d7d8c3b092023-06-15T16:11:55ZengWileyAnnals of Clinical and Translational Neurology2328-95032023-06-0110693394310.1002/acn3.51774A pilot study to explore the effect of udenafil on cerebral hemodynamics in older adultsQi Wang0Byoung‐Soo Shin1Sun‐Young Oh2Yu Seob Shin3Duk L. Na4Ko Woon Kim5Medical School Jeonbuk National University Jeonju South KoreaDepartment of Neurology Jeonbuk National University Medical School and Hospital Jeonju South KoreaDepartment of Neurology Jeonbuk National University Medical School and Hospital Jeonju South KoreaResearch Institute of Clinical Medicine of Jeonbuk National University‐Biomedical Research Institute of Jeonbuk National University Hospital Jeonju South KoreaDepartment of Neurology Sungkyunkwan University School of Medicine, Samsung Medical Center Seoul South KoreaDepartment of Neurology Jeonbuk National University Medical School and Hospital Jeonju South KoreaAbstract Objective Phosphodiesterase‐5 inhibitors (PDE5Is) enhance vasodilation. We investigated the effects of PDE5I on cerebral hemodynamics during cognitive tasks using functional near‐infrared spectroscopy (fNIRS). Methods This study used a crossover design. Twelve cognitively healthy men participants (mean age, 59 ± 3 years; range, 55–65 years) were recruited and randomly assigned to the experimental or control arm, then the experimental and control arm were exchanged after 1 week. Udenafil 100 mg was administered to participants in the experimental arm once daily for 3 days. We measured the fNIRS signal during the resting state and four cognitive tasks three times for each participant: at baseline, in the experimental arm, and in the control arm. Results Behavioral data did not show a significant difference between the experimental and control arms. The fNIRS signal showed significant decreases in the experimental arm compared to the control arm during several cognitive tests: verbal fluency test (left dorsolateral prefrontal cortex, T = −3.02, p = 0.014; left frontopolar cortex, T = −4.37, p = 0.002; right dorsolateral prefrontal cortex, T = −2.59, p = 0.027), Korean‐color word Stroop test (left orbitofrontal cortex, T = −3.61, p = 0.009), and social event memory test (left dorsolateral prefrontal cortex, T = −2.35, p = 0.043; left frontopolar cortex, T = −3.35, p = 0.01). Interpretation Our results showed a paradoxical effect of udenafil on cerebral hemodynamics in older adults. This contradicts our hypothesis, but it suggests that fNIRS is sensitive to changes in cerebral hemodynamics in response to PDE5Is.https://doi.org/10.1002/acn3.51774 |
| spellingShingle | Qi Wang Byoung‐Soo Shin Sun‐Young Oh Yu Seob Shin Duk L. Na Ko Woon Kim A pilot study to explore the effect of udenafil on cerebral hemodynamics in older adults Annals of Clinical and Translational Neurology |
| title | A pilot study to explore the effect of udenafil on cerebral hemodynamics in older adults |
| title_full | A pilot study to explore the effect of udenafil on cerebral hemodynamics in older adults |
| title_fullStr | A pilot study to explore the effect of udenafil on cerebral hemodynamics in older adults |
| title_full_unstemmed | A pilot study to explore the effect of udenafil on cerebral hemodynamics in older adults |
| title_short | A pilot study to explore the effect of udenafil on cerebral hemodynamics in older adults |
| title_sort | pilot study to explore the effect of udenafil on cerebral hemodynamics in older adults |
| url | https://doi.org/10.1002/acn3.51774 |
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