Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes
Background: Occupational exposure to pesticides has been reported among general population worldwide. However, little is known about the associations between non-occupational exposure to pesticides, and biological markers of health and their response by sex. Objectives: We aimed to assess the associ...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412021003913 |
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| author | Saranya Palaniswamy Khaled Abass Jaana Rysä Jon Øyvind Odland Joan O. Grimalt Arja Rautio Marjo-Riitta Järvelin |
| author_facet | Saranya Palaniswamy Khaled Abass Jaana Rysä Jon Øyvind Odland Joan O. Grimalt Arja Rautio Marjo-Riitta Järvelin |
| author_sort | Saranya Palaniswamy |
| collection | DOAJ |
| description | Background: Occupational exposure to pesticides has been reported among general population worldwide. However, little is known about the associations between non-occupational exposure to pesticides, and biological markers of health and their response by sex. Objectives: We aimed to assess the associations between non-occupational overall pesticide exposure, length of exposure and specific pesticides reported with 35 biological markers of health representing cardiometabolic, haematological, lung function, sex hormones, liver and kidney function profiles, and vitamin D in Finnish cohort. Methods: 31-year cross-sectional examination of the Northern Finland Birth Cohort 1966 provided blood samples for biomarker measurements in 1997–1998. Number of subjects varied between 2361 and 5037 for given exposures and certain outcome associations. Multivariable regression analyses were performed to examine associations between overall pesticide exposure (OPE), length of pesticide exposure in months (PEM), in years (PEY), and specific pesticides use (PEU) or not with cardiometabolic [SBP, DBP, TC, LDL, HDL, triglycerides, fasting glucose, insulin, HOMA-IR, HOMA-B, HOMA-S, hs-CRP], hematological [WBC, RBC, Hb, HCT, MCV, MCH, MCHC, platelets], lung function (FVC, FEV1), sex hormones [luteinizing hormone (LH), testosterone (TT), sex-hormone binding globulin (SHBG)], liver and kidney function profiles [total protein, albumin, globulin, ALP, ALT, GGT, urea, creatinine], and vitamin D adjusting for sex, BMI, socioeconomic position (SEP) and season of pesticide use. Results: This cohort study on up to 5037 adults with non-occupational OPE, PEM, PEY and PEU differed by sex and SEP. In regression analyses, all the exposures were positively associated with total cholesterol and low-density lipoprotein cholesterol, and PEU was negatively associated with high-density lipoprotein cholesterol in females. OPE and PEM were positively associated with haematocrit in females and PEU with platelets in males. PEU was negatively associated with mean corpuscular haemoglobin. OPE and PEM were positively associated with LH in males. OPE was negatively associated with total protein and albumin in males. Discussion: In Finnish young adults, non-occupational overall pesticide exposure, length of exposure and specific pesticides were associated with multiple biological markers of health. The biological markers seem to be indicative of adverse effects of pesticides and warrant for further studies to replicate the findings and determine the underlying mechanisms. |
| first_indexed | 2024-12-14T16:18:16Z |
| format | Article |
| id | doaj.art-cbd5b50eb3a84b6a89c7611897a3efa1 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-14T16:18:16Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
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| series | Environment International |
| spelling | doaj.art-cbd5b50eb3a84b6a89c7611897a3efa12022-12-21T22:54:52ZengElsevierEnvironment International0160-41202021-11-01156106766Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexesSaranya Palaniswamy0Khaled Abass1Jaana Rysä2Jon Øyvind Odland3Joan O. Grimalt4Arja Rautio5Marjo-Riitta Järvelin6Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Corresponding authors at: Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland (S. Palaniswamy and M-R. Järvelin).Arctic Health, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Pesticides, Menoufia University, Menoufia, EgyptSchool of Pharmacy, University of Eastern Finland, Kuopio, FinlandNTNU The Norwegian University of Science and Technology, Trondheim, Norway; Department of General Hygiene, I.M. Sechenov First Moscow State Medical University, Moscow, RussiaInstitute of Environmental Assessment and Water Research (IDAEA), Spanish Council for Scientific Research (CSIC), Barcelona, Catalonia, SpainArctic Health, Faculty of Medicine, University of Oulu, Oulu, Finland; Thule Institute, University of Arctic, University of Oulu, Oulu, Finland; Corresponding authors at: Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland (S. Palaniswamy and M-R. Järvelin).Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Unit of Primary Care, Oulu University Hospital, Oulu, Finland; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, United Kingdom; Corresponding authors at: Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland (S. Palaniswamy and M-R. Järvelin).Background: Occupational exposure to pesticides has been reported among general population worldwide. However, little is known about the associations between non-occupational exposure to pesticides, and biological markers of health and their response by sex. Objectives: We aimed to assess the associations between non-occupational overall pesticide exposure, length of exposure and specific pesticides reported with 35 biological markers of health representing cardiometabolic, haematological, lung function, sex hormones, liver and kidney function profiles, and vitamin D in Finnish cohort. Methods: 31-year cross-sectional examination of the Northern Finland Birth Cohort 1966 provided blood samples for biomarker measurements in 1997–1998. Number of subjects varied between 2361 and 5037 for given exposures and certain outcome associations. Multivariable regression analyses were performed to examine associations between overall pesticide exposure (OPE), length of pesticide exposure in months (PEM), in years (PEY), and specific pesticides use (PEU) or not with cardiometabolic [SBP, DBP, TC, LDL, HDL, triglycerides, fasting glucose, insulin, HOMA-IR, HOMA-B, HOMA-S, hs-CRP], hematological [WBC, RBC, Hb, HCT, MCV, MCH, MCHC, platelets], lung function (FVC, FEV1), sex hormones [luteinizing hormone (LH), testosterone (TT), sex-hormone binding globulin (SHBG)], liver and kidney function profiles [total protein, albumin, globulin, ALP, ALT, GGT, urea, creatinine], and vitamin D adjusting for sex, BMI, socioeconomic position (SEP) and season of pesticide use. Results: This cohort study on up to 5037 adults with non-occupational OPE, PEM, PEY and PEU differed by sex and SEP. In regression analyses, all the exposures were positively associated with total cholesterol and low-density lipoprotein cholesterol, and PEU was negatively associated with high-density lipoprotein cholesterol in females. OPE and PEM were positively associated with haematocrit in females and PEU with platelets in males. PEU was negatively associated with mean corpuscular haemoglobin. OPE and PEM were positively associated with LH in males. OPE was negatively associated with total protein and albumin in males. Discussion: In Finnish young adults, non-occupational overall pesticide exposure, length of exposure and specific pesticides were associated with multiple biological markers of health. The biological markers seem to be indicative of adverse effects of pesticides and warrant for further studies to replicate the findings and determine the underlying mechanisms.http://www.sciencedirect.com/science/article/pii/S0160412021003913PesticidesNon-occupational exposureBiological markersEndocrine disrupting chemicalsGeneral populationFinland |
| spellingShingle | Saranya Palaniswamy Khaled Abass Jaana Rysä Jon Øyvind Odland Joan O. Grimalt Arja Rautio Marjo-Riitta Järvelin Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes Environment International Pesticides Non-occupational exposure Biological markers Endocrine disrupting chemicals General population Finland |
| title | Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes |
| title_full | Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes |
| title_fullStr | Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes |
| title_full_unstemmed | Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes |
| title_short | Non-occupational exposure to pesticides and health markers in general population in Northern Finland: Differences between sexes |
| title_sort | non occupational exposure to pesticides and health markers in general population in northern finland differences between sexes |
| topic | Pesticides Non-occupational exposure Biological markers Endocrine disrupting chemicals General population Finland |
| url | http://www.sciencedirect.com/science/article/pii/S0160412021003913 |
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