Neuronal Phenotype of <i>col4a1</i> and <i>col25a1</i>: An Intriguing Hypothesis in Vertebrates Brain Aging
Collagens are the most abundant proteins in vertebrates and constitute the major components of the extracellular matrix. Collagens play an important and multifaceted role in the development and functioning of the nervous system and undergo structural remodeling and quantitative modifications during...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1778 |
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| author | Adele Leggieri Chiara Attanasio Antonio Palladino Paolo de Girolamo Carla Lucini Livia D’Angelo |
| author_facet | Adele Leggieri Chiara Attanasio Antonio Palladino Paolo de Girolamo Carla Lucini Livia D’Angelo |
| author_sort | Adele Leggieri |
| collection | DOAJ |
| description | Collagens are the most abundant proteins in vertebrates and constitute the major components of the extracellular matrix. Collagens play an important and multifaceted role in the development and functioning of the nervous system and undergo structural remodeling and quantitative modifications during aging. Here, we investigated the age-dependent regulation of <i>col4a1</i> and <i>col25a1</i> in the brain of the short-lived vertebrate <i>Nothobranchius furzeri</i>, a powerful model organism for aging research due to its natural fast-aging process and further characterized typical hallmarks of brain aging in this species. We showed that <i>col4a1</i> and <i>col25a1</i> are relatively well conserved during vertebrate evolution, and their expression significantly increases in the brain of <i>N. furzeri</i> upon aging. Noteworthy, we report that both <i>col4a1</i> and <i>col25a1</i> are expressed in cells with a neuronal phenotype, unlike what has already been documented in mammalian brain, in which only <i>col25a1</i> is considered a neuronal marker, whereas <i>col4a1</i> seems to be expressed only in endothelial cells. Overall, our findings encourage further investigation on the role of <i>col4a1</i> and <i>col25a1</i> in the biology of the vertebrate brain as well as the onset of aging and neurodegenerative diseases. |
| first_indexed | 2024-03-09T23:45:09Z |
| format | Article |
| id | doaj.art-cbd60fe17a2349c3abb7edd23d40471e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:45:09Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cbd60fe17a2349c3abb7edd23d40471e2023-11-23T16:46:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01233177810.3390/ijms23031778Neuronal Phenotype of <i>col4a1</i> and <i>col25a1</i>: An Intriguing Hypothesis in Vertebrates Brain AgingAdele Leggieri0Chiara Attanasio1Antonio Palladino2Paolo de Girolamo3Carla Lucini4Livia D’Angelo5Department Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Agricultural Sciences, University of Naples Federico II, Via Università 100, 80055 Portici, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyDepartment Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, ItalyCollagens are the most abundant proteins in vertebrates and constitute the major components of the extracellular matrix. Collagens play an important and multifaceted role in the development and functioning of the nervous system and undergo structural remodeling and quantitative modifications during aging. Here, we investigated the age-dependent regulation of <i>col4a1</i> and <i>col25a1</i> in the brain of the short-lived vertebrate <i>Nothobranchius furzeri</i>, a powerful model organism for aging research due to its natural fast-aging process and further characterized typical hallmarks of brain aging in this species. We showed that <i>col4a1</i> and <i>col25a1</i> are relatively well conserved during vertebrate evolution, and their expression significantly increases in the brain of <i>N. furzeri</i> upon aging. Noteworthy, we report that both <i>col4a1</i> and <i>col25a1</i> are expressed in cells with a neuronal phenotype, unlike what has already been documented in mammalian brain, in which only <i>col25a1</i> is considered a neuronal marker, whereas <i>col4a1</i> seems to be expressed only in endothelial cells. Overall, our findings encourage further investigation on the role of <i>col4a1</i> and <i>col25a1</i> in the biology of the vertebrate brain as well as the onset of aging and neurodegenerative diseases.https://www.mdpi.com/1422-0067/23/3/1778<i>Nothobranchius furzeri</i>collagensfishcentral nervous systemaging markers |
| spellingShingle | Adele Leggieri Chiara Attanasio Antonio Palladino Paolo de Girolamo Carla Lucini Livia D’Angelo Neuronal Phenotype of <i>col4a1</i> and <i>col25a1</i>: An Intriguing Hypothesis in Vertebrates Brain Aging International Journal of Molecular Sciences <i>Nothobranchius furzeri</i> collagens fish central nervous system aging markers |
| title | Neuronal Phenotype of <i>col4a1</i> and <i>col25a1</i>: An Intriguing Hypothesis in Vertebrates Brain Aging |
| title_full | Neuronal Phenotype of <i>col4a1</i> and <i>col25a1</i>: An Intriguing Hypothesis in Vertebrates Brain Aging |
| title_fullStr | Neuronal Phenotype of <i>col4a1</i> and <i>col25a1</i>: An Intriguing Hypothesis in Vertebrates Brain Aging |
| title_full_unstemmed | Neuronal Phenotype of <i>col4a1</i> and <i>col25a1</i>: An Intriguing Hypothesis in Vertebrates Brain Aging |
| title_short | Neuronal Phenotype of <i>col4a1</i> and <i>col25a1</i>: An Intriguing Hypothesis in Vertebrates Brain Aging |
| title_sort | neuronal phenotype of i col4a1 i and i col25a1 i an intriguing hypothesis in vertebrates brain aging |
| topic | <i>Nothobranchius furzeri</i> collagens fish central nervous system aging markers |
| url | https://www.mdpi.com/1422-0067/23/3/1778 |
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